Bioinformatics Scientist

Guidehouse; Bethesda (MD); On-site; USD 65,000 - 108,000; Full time

Benefits offered by this job

Medical Insurance

Dental Insurance

Vision Insurance

401(k)

Paid Holidays

Tuition Reimbursement

Parental Leave

Job summary

Guidehouse in Bethesda, MD is seeking a Bioinformatics Scientist (Scientist V) to support the Vaccine Research Center at NIAID, applying advanced computational biology and analysis of multimodal single-cell data.

The role requires strong Python/R skills, SLURM HPC experience, and ability to collaborate across disciplines. On-site position with competitive salary and comprehensive benefits.

Qualifications

• Masters degree in bioinformatics or related field.
• At least 2 years experience with multimodal single-cell datasets.
• Proficiency in Python and R programming languages.
• Experience with SLURM-managed HPC clusters.
• Strong analytical, statistical, and problem-solving skills.
• Excellent written and verbal communication skills.

Responsibilities

• Implement and utilize workflows for NGS QC and data analysis.
• Collaborate across organizations and institutions on related research.
• Provide mentorship and guidance on bioinformatics pipelines for spatial transcriptomics.
• Provide programming and troubleshooting support for dissemination of research data.
• Perform computational analysis to identify trends and patterns in datasets.
• Document analyses and present results at lab meetings.

Skills

Python

R

HPC SLURM

NGS workflows

Data analysis

Scientific communication

Education

Master’s Degree in Bioinformatics or related

PhD in Bioinformatics (nice to have)

Tools

Xenium

Visium

Spatial transcriptomics

Job description

Job Family:

Scientist

Travel Required:

None

Clearance Required:

Ability to Obtain Public Trust

What You Will Do:

We are looking for a Bioinformatics Scientist (Scientist V) in the IBIS Core to support the Vaccine Research Center (VRC) at NIAID through advanced computational biology and bioinformatics analysis. This position is a full-time position located in Bethesda, MD.

• Implement and utilize workflows for next generation sequencing (NGS), including quality control (QC) and data analysis.
• Initiate interdisciplinary collaborations with scientists from other organizations or institutions engaged in related research.
• Provide scientific mentorship and guidance to students, postdoctoral fellows, technicians, and other staff in developing bioinformatics pipelines, particularly for spatial transcriptomics applications.
• Provide programming and troubleshooting support to the Federal Government in the dissemination of research data.
• Perform computational analysis of research datasets and identify trends and patterns.
• Collaborate with multidisciplinary teams to design, analyze, manage, and interpret complex biological data.
• Maintain detailed documentation of analyses and present results at laboratory meetings.
• Develop novel computational programs and algorithms to facilitate discovery in large and complex datasets.
• Evaluate and adapt bioinformatics techniques based on scientific literature, available resources, and research objectives.
• Collaborate with experimentalists and computational scientists to develop new computational tools for scientific discovery.
• Independently coordinate training of personnel on scientific, statistical, and programmatic software applications.
• Present research findings at internal meetings, conferences, and seminars; contribute to scientific publications.
• Attend scientific and programming meetings and maintain organized records of findings and discussions.

What You Will Need:

• Master’s Degree in Bioinformatics, Computational Biology, or a related discipline.
• A minimum of TWO (2) years of experience working with large, multimodal single-cell datasets.
• Proficiency in Python and R programming languages.
• Practical knowledge of and experience working with SLURM-managed high-performance computing (HPC) clusters.
• Strong analytical, statistical, and problem-solving skills.
• Experience with next generation sequencing (NGS) workflows and data analysis.
• Ability to collaborate effectively in a multidisciplinary research environment.
• Strong written and verbal communication skills, including presentation of scientific data.
• Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

What Would Be Nice To Have:

• Ph.D. in Bioinformatics, Computational Biology, or a related discipline preferred.
• Experience with Xenium and/or Visium spatial transcriptomics platforms is preferred.
• Familiarity with adaptive immune receptor repertoires and general immunology are beneficial.

The annual salary range for this position is $65,000.00-$108,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical, Rx, Dental & Vision Insurance

• Personal and Family Sick Time & Company Paid Holidays

• Parental Leave

• 401(k) Retirement Plan

• Group Term Life and Travel Assistance

• Voluntary Life and AD&D Insurance

• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts

• Transit and Parking Commuter Benefits

• Short-Term & Long-Term Disability

• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities

• Employee Referral Program

• Corporate Sponsored Events & Community Outreach

• Care.com annual membership

• Employee Assistance Program

• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)

• Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at [e-mail]. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or [e-mail]. Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse. Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.

If any person or organization demands money related to a job opportunity with Guidehouse, please report the matter to Guidehouse’s Ethics Hotline. If you want to check the validity of correspondence you have received, please contact [e-mail]. Guidehouse is not responsible for losses incurred (monetary or otherwise) from an applicant’s dealings with unauthorized third parties.

Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.