Bioinformatics Scientist

GAP SOLUTIONS INC; Bethesda (MD); On-site; USD 110,000 - 160,000; Full time

Job summary

GAP Solutions Inc. is seeking a Bioinformatics Scientist to support the National Cancer Institute within the NIH.

The role focuses on optimizing Exome/Targeted/RNA sequencing data analysis pipelines for clinical sequencing projects, integrating complex genomic data, and creating data compendia of variations from tumor/normal samples. The candidate will install and maintain a local cBIO Portal, upload data for visualization, process data on Biowulf, and contribute to manuscripts and

Qualifications

• Master’s degree in Bioinformatics or related field.

Responsibilities

• Develop pipelines to optimize Exome/Targeted/RNA Sequencing Data Analysis pipelines for clinical sequencing projects.

Skills

R

RNA-Seq data analysis

Bulk RNA-Seq

Single Cell RNA-Seq

Genomic data integration

Education

Master’s degree in Bioinformatics or related field

Tools

cBIO Portal

ANNOVAR

1000 Genomes

ExAC

My Cancer Genome

ClinSeq

ESP

ClinVar

HGMD

Job description

Position Objective: The Bioinformatics Scientist will provide support services to the National Cancer Institute within the National Institutes of Health.Duties and Responsibilities:Use existing infrastructure and optimize Exome/Targeted/RNA Sequencing DataAnalysis pipelines for clinical sequencing projects. 1Develop pipelines to integrate complex genomic data including germ line, somaticDNA mutations, RNAseq and SNP assays. 2Work with staff on the production of a data compendium enumerating the frequency of variations from tumor/normal samples. 3Install and maintain local version of cBIO Portal.Upload Labs Data on cBIO Portal for easy visualization.Work with staff to utilize NIH Biowulf computer clusters to process data streamed off the next generation sequencers (NGS); process data in a batch mode. Perform biological sequence analysis/assembly and public genome databases.Collect and review data; analyze and interpret data and results; provide reports based on analysis of scientific data.Report research outcomes and make recommendations for future work.Work with staff on data visualization to support the preparation of presentations and manuscripts for submission to scientific journals.Bioinformatics Lab meetings, scheduling and notes writing.Co-write manuscripts.Develop annotation algorithms and databases with all publically available data including Annovar, 1000genomes, ExAC, MyCancerGenome, ClinSeq, ESP, ClinVar, HGMD and other databases as released.Develop new algorithms for analysis of next generation sequencing and other genomics data.Support implementation of publically available tools in local server environment.Write manuals to implement tools for other users.Teach staff to use NGS and other genomic analysis tools.Provide advice to staff about data analysis pipelines.Work products and documents related to using existing infrastructure and optimizing pipelines for clinical sequencing projects; develop pipelines to integrate data; work with staff on the production of a data compendium enumerating the frequency of variations from tumor/normal samples.Work products and documents related to installing and maintaining local version of cBIOPortal; upload data on cBIO Portal; process data streamed off the NGS; process data in a batch mode.Work products and documents related to performing biological sequence analysis/ assembly; collect, review, analyze and interpret data; prepare reports; manage Bioinformatics Lab meetings; co-write manuscripts.Work products and documents related to developing annotation algorithms and databases; develop new algorithms for analysis of next generation sequencing and other genomics data.Work products and documents related to implementing tools in local server environment; write manuals; teach staffBasic Qualifications:Master’s degree in Bioinformatics or related field of studySkilled in R, Next gen sequencing data analysis: Bulk RNA-SequencingSingle Cell RNA-Sequencing, and working with large data setsPreferred Qualifications:Ability to communicate effectively, orally and in writing, with non-technical and technical staffDetail-oriented and possess strong organizational skills with the ability to prioritize multiple tasks and projects*This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required by this position.To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.GAP Solutions provides reasonable accommodations to qualified individuals with disabilities. If you need an accommodation to apply for a job, email us at [e-mail]. You will need to reference the requisition number of the position in which you are interested. Your message will be routed to the appropriate recruiter who will assist you. Please note, this email address is only to be used for those individuals who need an accommodation to apply for a job. Emails for any other reason or those that do not include a requisition number will not be returned.Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, protected veteran status or other characteristics protected by law.This position is contingent upon contract award.