Bioinformatics Engineer

Pilgrim; Redwood City (CA); On-site; USD 140,000 - 170,000; Full time

Job summary

Pilgrim, based in Redwood City, seeks a Bioinformatics Engineer to develop methods and software to characterize sequencing data from ARGUS and build metagenomic pipelines that run at the edge.

You will validate detection accuracy and optimize pipelines for onboard hardware, aiming to reduce latency and memory usage while benchmarking performance on independent datasets.

Qualifications

• Strong foundation in bioinformatics, computational biology, or scientific computing.
• Hands-on experience analyzing sequencing data, including read quality assessment, alignment, or taxonomic classification.
• Proficiency in Python, C++, Rust, or a similar language for building bioinformatics software.
• Ability to use AI coding tools and independently review, test, and debug the code they produce.
• Experience benchmarking analysis methods with independent test data and measuring precision, recall, or false positive rates.
• Demonstrated improvements to runtime, memory use, or throughput on large datasets through software profiling and optimization.

Responsibilities

• Develop and evaluate methods for agnostic detection and identification of organisms in metagenomic data, including mixed samples and low-abundance signals.
• Build sequencing pipelines covering basecalling, read quality control, classification, and reporting of detection evidence and uncertainty.
• Profile and optimize pipelines for ARGUS’s onboard hardware, reducing latency and memory use.
• Benchmark detection performance on independent datasets, measuring false positives, false negatives, and time to detection.
• Version reference databases and maintain regression tests to catch performance changes after software or database updates.
• Investigate ambiguous findings with scientists, including contamination, preparation artifacts, and gaps or errors in reference data.
• Evaluate algorithms and machine learning methods against established approaches; deploy those that improve detection or computational performance.

Skills

Bioinformatics

Python

C++

Rust

Machine learning

Education

MS or PhD preferred

Tools

Python ecosystem

C++

Rust

Job description

About Pilgrim:

Pilgrim is building America’s biology prime - engineering, manufacturing, and deploying advanced biotechnology for defense and national security. Our primary platform, ARGUS, is a fully autonomous system for detecting biological threats in near real time, from naturally occurring pathogens to engineered agents.

We engineer hardware for biology, turning breakthrough science into fielded capabilities. Based in Redwood City, our team brings together mechanical and electrical engineering, chemistry, and biology under one roof to deliver critical technologies to the people who need them.

Pilgrim has raised over $30 million to date and is backed by Peter Thiel, Brian Armstrong, Fred Ehrsam, Dylan Field, and Bryan Johnson, alongside Buckley Ventures, Conviction, Cantos, and others.

About the Role:

As a Bioinformatics Engineer at Pilgrim, you’ll develop methods and software to characterize sequencing data from ARGUS. You’ll build metagenomic analysis pipelines that process reads as they arrive and run efficiently at the edge. You’ll validate detection accuracy so operators can trust what ARGUS reports.

Responsibilities:

• Develop and evaluate methods for agnostic detection and identification of organisms in metagenomic data, including mixed samples and low-abundance signals.

• Build sequencing pipelines covering basecalling, read quality control, classification, and reporting of detection evidence and uncertainty.

• Profile and optimize pipelines for ARGUS’s onboard hardware, reducing latency and memory use.

• Benchmark detection performance on independent datasets, measuring false positives, false negatives, and time to detection.

• Version reference databases and maintain regression tests to catch performance changes after software or database updates.

• Investigate ambiguous findings with scientists, including contamination, preparation artifacts, and gaps or errors in reference data.

• Evaluate algorithms and machine learning methods against established approaches; deploy those that improve detection or computational performance.

Qualifications:

• Strong foundation in bioinformatics, computational biology, or scientific computing. MS or PhD is a plus, not required.

• Hands-on experience analyzing sequencing data, including read quality assessment, alignment, or taxonomic classification.

• Proficiency in Python, C++, Rust, or a similar language for building bioinformatics software.

• Ability to use AI coding tools and independently review, test, and debug the code they produce.

• Experience benchmarking analysis methods with independent test data and measuring precision, recall, or false positive rates.

• Demonstrated improvements to runtime, memory use, or throughput on large datasets through software profiling and optimization.

Preferred:

• Experience with nanopore sequencing, metagenomics, microbial genomics, streaming analysis, or deployment on resource-constrained hardware.

Pilgrim is an equal opportunity employer. We do not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, veteran status, or any other characteristic protected by law. Certain positions require access to export-controlled information and are limited to U.S. Persons as defined by applicable export control regulations.