Bioinformatician I

Partner's Healthcare; Boston (MA); Hybrid; USD 75,000 - 110,000; Full time

Job summary

Mass General Brigham is seeking a Bioinformatician to develop, validate, and optimize computational prediction models using large-scale multi-omic and clinical data. You will build reproducible workflows, optimize code for HPC environments, and ensure robust model validation across cohorts.

The role collaborates with investigators and external partners to address data processing differences, perform advanced analyses, and contribute to manuscripts and grant-related analyses.

Qualifications

• Bachelor's Degree in Computational Biology or a related field is required.
• Master's Degree in a related field is preferred.
• Experience in computational sciences and bioinformatics software is important.

Responsibilities

• Analyze complex biological and multi-omic data using bioinformatics tools.
• Develop and validate reproducible analysis pipelines.
• Collaborate with investigators to interpret results and improve models.
• Lead development of multi-omic risk prediction models in large cohorts.
• Document methods and ensure reproducibility and auditability.

Skills

Bioinformatics

Data analysis

Machine learning

Statistics

Python

Education

Bachelor's Degree Computational Biology

Master's Degree Related Field

Tools

R

Python

SQL

HPC

Job description

Site: The Brigham and Women's Hospital, Inc.Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary

This is a one-year, fixed-term position with an anticipated duration of 12 months.

Bioinformatician: Computational Omics and Predictive Modeling

Responsible for developing, implementing, adapting, and validating computational prediction models using large-scale multi-omic, clinical, and phenotypic data. The role develops reproducible analytical workflows, optimizes code for high-performance computing, addresses cross-cohort differences in data processing and feature availability, and evaluates model performance in independent datasets across clinically relevant prediction horizons. Works collaboratively with investigators and external partners to ensure rigorous, reproducible, and interpretable model validation.

Essential Functions (Key Roles & Responsibilities)

• Independently conduct and support analysis of complex biological and multi-omic data using bioinformatics tools and software.
• Perform data processing, quality control, and database maintenance.
• Collaborate with research teams to understand their data analysis needs.
• Develop, implement, validate, and maintain reproducible data analysis pipelines
• Conduct advanced statistical and bioinformatic analyses and data visualization
• Lead or substantially contribute to interpretation and presentation of analytical results
• Working under very general supervision, the Bioinformatics Analyst will have demonstrated independent design and innovation in one or more of the following areas of specialization: algorithm development, data analysis, quality assurance/testing, pipeline software/computing development, user interface design & report development, web-based application development, or report development.
• Develop and validate multi-omic risk prediction models in a series of large cohorts.
• Design and evaluate statistical and machine-learning approaches for high-dimensional biological and clinical data
• Independently troubleshoot computational, analytical, and data-quality issues.
• Document methods, code, assumptions, and analytic decisions to ensure reproducibility and auditability
• Optimize workflows for large-scale and high-performance computing environments
• Conduct data analysis to uncover trends, patterns, and anomalies.
• Collaborate effectively with cross-functional teams.
• Support research security and compliance oversight by collaborating with the Institutional Review Board and other research governing bodies.
• Adhere to rigorous principles of reproducible research and data documentation.
• Substantially contribute to manuscripts, abstracts, reports, presentations, and grant-related analyses (e.g., scientific literature, reports, journal publications and presentations).
• Performs other duties as assigned
• Complies with all policies and standards

Qualifications Education

• Bachelor's Degree Computational Biology or Related Field of Study required
• Master's Degree Related Field of Study preferred

Experience

• Computational Sciences Experience: 0-1 year.
• Computational Sciences Experience: 3+ years preferred

Knowledge, Skills and Abilities

Demonstrated experience in infrastructure, programming languages, and computational sciences.Demonstrated ability working with open-source bioinformatics software.Possess strong analytical skills, including critical thinking, data modeling, problem solving, and troubleshooting.Strong organizational and interpersonal skills.Ability to effectively communicate, both orally and in writing, to all levels of staff.Excellent time management skills.

Additional Job Details (if applicable)

Remote Type HybridWork Location 1620 Tremont StreetScheduled Weekly Hours 40Employee Type RegularWork Shift Day (United States of America)

Pay Range $75,275.20 - $109,553.60/AnnualGrade 6

At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth.

EEO Statement: 2200

The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.