Bioengineer, Technical Solutions

Ori Biotech; Philadelphia (Philadelphia County); On-site; USD 60,000 - 100,000; Full time

Job summary

An established industry player is seeking a motivated Bioengineer to join their innovative team in the cell and gene therapy space. This role is pivotal in enhancing patient access to life-saving therapies by optimizing manufacturing processes and driving technology adoption. You will engage in hands-on laboratory work, collaborate with various stakeholders, and contribute to training programs and product demonstrations. This is a unique opportunity to make a significant impact in the field of cell therapy, working alongside passionate experts dedicated to transforming patient outcomes. If you thrive in dynamic environments and are eager to contribute to groundbreaking advancements, this position is perfect for you.

Qualifications

• 2+ years experience in Life Science, biologics or cell therapies.
• Familiarity with cell culture and processing technologies.

Responsibilities

• Support lab development activities and maintain laboratory organization.
• Develop SOPs and protocols for customers and support technology transfer.

Skills

Excellent oral and written communication skills

Agility in a start-up environment

Attention to detail

Project management skills

Ability to engage with colleagues

Passion for patient outcomes

Tools

Flow Cytometry

ELISA

qPCR

Job description

Ori Biotech is on a mission to enable widespread patient access to life-saving cell and gene therapies.

Ori launched IRO, a next-generation CGT manufacturing platform, as a first step towards achieving this mission. The IRO platform is designed to automate better biology and accelerate therapy development to help make these treatments more affordable and widely available to patients.

Scientific breakthroughs continue to be made in cell and gene therapy across a wide range of diseases, including cancer and rare genetic diseases. Despite these advancements, it is estimated that more than 95% of patients who could benefit from this new class of life-saving therapies are left without access.

The challenge is that these transformative treatments are difficult and expensive to manufacture due to the high cost of goods and low throughput limiting the ability to meet patient demand.

This is where Ori Biotech comes in. Our team of leading gene therapy and life sciences veterans are working in collaboration with industry partners to develop innovations that deliver exceptional biology while reducing the time and cost to develop and manufacture cell therapies to help enable widespread patient access to life-saving cell and gene therapies.

With the commercial launch of IRO, Ori is in a rapid growth phase backed by some of the top VCs in the US and UK. We are looking for trailblazers, visionaries and the naturally inquisitive; those who can challenge and those who can inspire at this very exciting time.

This is an excellent time to join our world-class team and to be an integral part of changing history by helping to ensure patient access to CGT treatments.

Job Description

We are looking for a highly motivated and hands-on Bioengineer to play a pivotal role in supporting Ori’s customers and internal development programs. You will be at the forefront of cell therapy manufacturing innovation, driving technology adoption and optimizing processes to help customers bring life-saving therapies to market faster.

Your expertise will contribute to training programs, product demonstrations, and cutting-edge process development that leverages Ori’s transformative platform. You will join a team of high-performing individuals, passionate about making a difference in patient outcomes, and you will collaborate with various stakeholders across the business.

Key Responsibilities

• Basic laboratory maintenance and organization, including materials inventory
• Support laboratory-based development activities across a range of projects and clients
• Work with a range of cell-based techniques and engineering techniques including cell culture, cell counts, flow cytometry, ELISA, and qPCR
• Work with third-party vendors for additional services (mycoplasma, sterility, endotoxin)
• Progression of research-based manufacturing processes to scalable clinical manufacturing protocols that become suitable for commercial use by incorporating Ori technology
• Support technology transfer to customers, through instrument setup/IQOQ, customer trainings/demonstrations, and troubleshooting exercises
• Develop SOPs, protocols, and reports for customers
• Provide support and feedback to product design and development activities.
• Evaluate new technologies, through lab work, for product fit within the market
• Maintain an active industry network to stay abreast of the latest technology trends, partnership opportunities, and competitive technologies
• Training of junior staff members

Experience

• 2+ years of experience within an appropriate Life Science environment either with biologics or cell therapies
• Experienced in novel cell processing technologies, particularly within upstream cell bioprocessing is highly desirable
• Cell culture experience with either Immune cells (Lymphocytes, PBMC, Dendritic cells), HSC CD34+ cells, hESC, hiPS, MSC, or other clinically relevant cell types
• Experienced in cell isolation from one or more of the following sources: apheresis, peripheral or cord blood, and/or bone marrow
• Demonstrable experience in relevant analytical techniques (Cell counts, Flow Cytometry, metabolite analysis, PCR)
• Excellent working knowledge of the cell therapy industry
• Working knowledge of GMP is preferred
• Experience in customer service is preferred

Skills

• Excellent oral and written communication skills
• Ability to be agile and work in a start-up environment with a strong focus on attention to detail
• Takes initiative when required but keeps others informed of decisions
• Excellent organizational skills and project management skills
• Proven ability to engage constructively with colleagues at all levels across different departments to deliver objectives
• Passionate about wanting to make a difference in patient outcomes

Contract Type: Permanent

Please send an up to date CV, with salary expectations with a short cover note indicating your suitability to [e-mail]

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