Bioconjugation Scientist — Targeted RNA Delivery

The RNA Society; Indiana (PA); On-site; USD 93,516 - 148,067; Full time

Benefits offered by this job

Competitive compensation package

Attractive benefits

Job summary

NATi is conducting a global search for a bench-level scientist to develop ligand-oligonucleotide conjugates (LOCs) for extrahepatic RNA delivery. The role emphasizes hands-on experimentation, project leadership, and collaboration across chemists, biologists, and pharmacologists.

The successful candidate will design, synthesize, and characterize LOCs targeting skeletal/cardiac muscle, adipose tissue, and ocular compartments.

Qualifications

• Doctorate required in a related field.
• 2–6 years industry experience in bioconjugation for LOCs/ADCs/PDCs or targeted delivery.
• Hands-on experience establishing conjugation chemistries (Click, lysine/cysteine coupling, enzymatic ligation, stimuli-sensitive linkers).
• Proficiency in multiscale purification methods (RP-HPLC, affinity, ion-exchange, HIC, SEC, TFF) and instruments.

Responsibilities

• Design and execute LOC conjugation strategies to optimize delivery.
• Perform synthesis, purification, and analytical characterization of LOCs.
• Collaborate with oligonucleotide chemists, biologists, and pharmacologists for in vitro/in vivo evaluation.
• Coordinate with CROs and manage reagents for ligand libraries and conjugation reagents.
• Maintain rigorous documentation of procedures and data interpretation.
• Contribute to innovation and IP through novel conjugation approaches and delivery strategies.
• Present findings in internal meetings and contribute to reports, publications, and filings.

Skills

Bioconjugation chemistry

Targeted delivery

Project leadership

Cross-functional collaboration

Analytical thinking

Education

PhD in Chemistry / Chemical Biology / Organic or Medicinal Chemistry

Tools

RP-HPLC

LC-MS

LC-HRMS

NMR

TFF (Tangential Flow Filtration)

Job description

NATi is conducting a global search for a bench-level scientist to develop ligand-oligonucleotide conjugates (LOCs) for extrahepatic RNA delivery. The role emphasizes hands-on experimentation, project leadership, and collaboration across chemists, biologists, and pharmacologists.

The successful candidate will design, synthesize, and characterize LOCs targeting skeletal/cardiac muscle, adipose tissue, and ocular compartments.