AVP Enterprise AI Architecture and Strategy

Penn Medicine; Philadelphia (Philadelphia County); On-site; USD 180,000 - 270,000; Full time

Job summary

Penn Medicine seeks a senior leader to define and govern the enterprise AI technology strategy and architecture in a highly regulated healthcare setting. The AVP will drive multi-year roadmaps, architecture standards, and governance, partnering with security, legal, compliance, and clinical teams.

Responsibilities include leading an AI architecture team, ensuring safe and compliant AI investments, and aligning AI initiatives with clinical care, research, and operations.

Qualifications

• Bachelor's degree required.
• 15+ years of Information Technology experience.
• 7+ years of Enterprise Architecture Leadership experience.
• 3+ years AI Enterprise Architect & Strategy experience.

Responsibilities

• Defines and owns the enterprise AI technology strategy, ensuring alignment with healthcare, clinical, research, and business strategies.
• Builds a high performing AI architecture team.
• Sets performance expectations, develops talent, and ensures organizational maturity and succession readiness.
• Develops and executes a multi-year enterprise AI architecture and strategy roadmap aligned to investment planning and value realization.
• Establishes enterprise standards and reference architectures for AI/ML, GenAI platforms, and governance.

Skills

AI architecture leadership

Enterprise architecture

Governance

AI strategy

Education

Bachelore2s degree

15+ years IT experience

7+ years Enterprise Architecture Leadership

3+ years AI Enterprise Architect & Strategy

Job description

Description

Penn Medicine is dedicated to our tripartite mission of providing the highest level of care to patients, conducting innovative research, and educating future leaders in the field of medicine. Working for this leading academic medical center means collaboration with top clinical, technical and business professionals across all disciplines.

Today at Penn Medicine, someone will make a breakthrough. Someone will heal a heart, deliver hopeful news, and give comfort and reassurance. Our employees shape our future each day. Are you living your life's work?

Entity: Corporate Services

Department: Enterprise Technology Architecture and Strategy

Location: 3535 Market St

Summary

• Reporting to the VP, Enterprise Technology Architecture and Strategy, the Associate Vice President (AVP), Enterprise AI Architecture and Strategy is the leadership role responsible for defining, governing, and advancing the organization's enterprise wide AI and Gen AI strategy and architecture within a complex, highly regulated healthcare environment.
• This role serves as the enterprise leader for AI technology strategy, architecture, and governance, accountable for aligning AI vision, roadmap, standards, and operating model with organizational strategy across clinical care, research, academic, and operation domains. The AVP ensures AI technology investments are clinically safe, ethically sound, secure, scalable, and compliant, while enabling innovation that improves patient outcomes, operational efficiency, and institutional performance.
• The AVP leads Enterprise AI Architecture and Strategy practice as a core component of Enterprise Architecture, owning multi-year AI technology strategy and architecture roadmaps, reference architectures, and governance frameworks. In close partnership with executive leadership, clinical informatics, digital health, data, security, privacy, legal, compliance, and risk management teams, the AVP balances innovation velocity with patient safety, regulatory obligations, and enterprise resilience, ensuring responsible and sustainable adoption of AI at scale.

Responsibilities

• Defines and owns the enterprise AI technology strategy, ensuring alignment with healthcare, clinical, research, and business strategies
• Builds a high performing AI architecture team
• Sets performance expectations, develops talent, and ensures organizational maturity and succession readiness
• Develops and executes a multi-year enterprise AI architecture and strategy roadmap aligned to investment planning and value realization
• Establishes enterprise standards and reference architectures for:
  • AI/ML and GenAI platforms
  • Agentic AI Orchestration, agent framework, and multi-agent ecosystems
  • AI monitoring, observability, and performance management
  • LLM model lifecycle management (development, validation, deployment, monitoring, retirement)
  • Integration with EHRs, clinical systems, research platforms, and enterprise applications
  • Monitoring and observability
• Oversee AI and GenAI governance, including architecture review, model risk management, clinical safety considerations, and ethical AI practices
• Partners with Information Security, Privacy, Legal, Compliance, Clinical Informatics, and Risk Management to ensure compliance with: HIPAA and healthcare data privacy, AI related regulations, accreditation, and audit requirements
• Provide enterprise direction, expectations, and guardrails for how AI must behave, be governed, and be trusted, especially where AI affects patients, clinicians, research, or regulated decisions.
• Represents Enterprise Architecture in AI investment decisions, portfolio governance, and executive steering committees
• Defines and tracks architecture KPIs, communicating outcomes, risks, and value realization to senior executive leadership.
• Serves as an internal and external thought leader for enterprise and healthcare AI strategy and architecture

Credentials

• Certified Machine Learning, Professional ML Engineer, AI Governance, or equivalent AI certification is preferred.

Education or Equivalent Experience

• Bachelor's degree is required.
• 15+ years of Information Technology (IT) experience, with 7+ years Enterprise Architecture Leadership is required.
• 3+ years AI Enterprise Architect & Strategy is required.

We believe that the best care for our patients starts with the best care for our employees. Our employee benefits programs help our employees get healthy and stay healthy. We offer a comprehensive compensation and benefits program that includes one of the finest prepaid tuition assistance programs in the region. Penn Medicine employees are actively engaged and committed to our mission. Together we will continue to make medical advances that help people live longer, healthier lives.

Live Your Life's Work

We are an Equal Opportunity employer. Candidates are considered for employment without regard to race, ethnicity, color, sex, sexual orientation, gender identity, religion, national origin, ancestry, age, disability, marital status, familial status, genetic information, domestic or sexual violence victim status, citizenship status, military status, status as a protected veteran or any other status protected by applicable law.