Automation Engineer III: Liquid Handling & Manufacturing

10x Genomics, Inc.; Pleasanton (CA); Hybrid; USD 120,000 - 160,000; Full time

Benefits offered by this job

Equity grants

Health and retirement benefits

Annual bonus program

Job summary

10x Genomics is seeking an Automation Engineer III for its Manufacturing Systems Engineering Group in Pleasanton, CA. You will develop and validate automated liquid handling methods on Hamilton systems (STAR family) using VENUS and HSL, with a focus on scalable, well-documented code and cross‑functional collaboration across R&D, Process Development, Manufacturing and Quality teams.

The role emphasizes root-cause investigations, qualification activities (IQ/OQ/PQ), and implementing improvements

Qualifications

• Bachelor’s or master’s degree in Engineering, Life Science, Computer Science, or equivalent.
• 5+ years of relevant industry experience in manufacturing or lab automation.
• 3+ years of hands-on Hamilton liquid handler method development in VENUS, including peripheral integration.
• Demonstrated ability to write scalable, maintainable liquid handling code with documentation.

Responsibilities

• Develop, program, troubleshoot, and optimize automated liquid handling methods on Hamilton liquid handlers for Manufacturing.
• Write scalable, modular liquid handling code with version control.
• Develop, optimize, and validate liquid classes and integrate Hamilton peripherals.
• Lead root cause investigations on liquid handling issues including cross‑contamination and carryover.
• Develop QC methods to verify liquid handling performance and use statistics to qualify equipment.
• Onboard and support analytical instrumentation and API integrations with liquid handlers.
• Scope, design, and deliver small automation projects and troubleshoot equipment.
• Support equipment transfers, IQ/OQ/PQ qualification and validation activities.
• Develop work instructions and qualification documentation for new equipment.
• Establish maintenance plans and identify improvements to reliability and yield.
• Create procedures supporting ISO 9001 QMS including FMEAs.
• Use AI tools to accelerate code development and data analysis.
• Provide production support and continuous improvement for existing methods.

Skills

Hands-on engineering

Cross-functional collaboration

Root-cause analysis

Strong communication

Adaptability for swing/weekends

Education

Bachelor’s or Master’s in Engineering/Life Science/CS

Tools

Hamilton VENUS

Hamilton HSL

AI coding tools

Hamilton peripherals

Scripting languages

Job description

10x Genomics is seeking an Automation Engineer III for its Manufacturing Systems Engineering Group in Pleasanton, CA. You will develop and validate automated liquid handling methods on Hamilton systems (STAR family) using VENUS and HSL, with a focus on scalable, well-documented code and cross‑functional collaboration across R&D, Process Development, Manufacturing and Quality teams.

The role emphasizes root-cause investigations, qualification activities (IQ/OQ/PQ), and implementing improvements