Asst Research Scientist/Engin - MORL

The University of Iowa; Iowa City (IA); Sur place; USD 55 000 - 70 000; Plein temps

Résumé du poste

The University of Iowa MORL seeks a Research Assistant to conduct highly technical genetic deafness research, exploring genotype-phenotype relationships, gene discovery, and gene therapy using rodent models. The role includes independent project work, data analysis, and dissemination of findings.

Responsibilities cover experimental design, protocol development, funding activities, and collaboration with faculty.

Qualifications

• PhD-level or equivalent required; post-doctoral experience in hearing genetics preferred.
• Strong in vivo rodent experiments and hearing testing techniques (ABR/DPOAE).
• Experience with gene therapy concepts and cochlear tissue handling is highly desirable.

Responsabilités

• Plan and execute genetic/deafness research projects with some independence.
• Conduct experiments and collect data; ensure data integrity for analyses.
• Prepare results for publication and presentations at conferences.

Connaissances

Rodent in vivo techniques

Hearing assessment ABR/DPOAE

Data analysis

Gene therapy basics

Formation

Doctorate in molecular biology or genetics

Post-doctoral research experience

DDS or DVM (alternative degree)

Outils

GraphPad Prism

ImageJ

PCR/RT-qPCR

Western blotting

Immunofluorescence

Description du poste

The Department of Otolaryngology- Molecular Otolaryngology and Renal Research Laboratories (MORL) is seeking a Research Assistant to conduct highly technical and specialized scientific research focused on genetic deafness (autosomal recessive and dominant nonsyndromic hearing loss), exploring phenotype-genotype relationships, novel gene discovery, gene therapy, and the contribution of genetics to age-related hearing loss. This individual will evaluate genetic data to determine genotype-phenotype correlations and develop methodology to identify novel disease-causing loci. Additionally, they will independently secure funding, conduct research experiments, analyze data, and disseminate findings through publications and presentations.

Duties to include:

Experiments, Simulations, Modeling or Theoretical Investigations:

Interrogate genetic regions of interest related to autosomal recessive and dominant non-syndromic hearing loss through methods such as in vivo and molecular experiments, including cell culture, immunohistochemistry, and viral vector injections in rodent models.

Collect and evaluate data integrity and relevance to research questions.

Evaluate data to establish relevance to the problem or problems being evaluated.

Define outstanding research problems and contribute to protocol development

Work independently on research tasks with oversight by Principal Investigator (PI).

Contribute to documentation of equipment and procedures.

Develop new protocols for research and obtain support for new and/or continuing research activities.

Data/Research Analysis and Evaluation:

Analyze data for relevance and data integrity.

Compare results of scientific investigations to previously published work.

Dissemination of Research Results:

Prepare research results for publication in reports, papers, journals, books and other media.

Prepare seminars, discussions and lectures for dissemination of knowledge and results of research.

Represent the entire research group at professional meetings.

Research Proposals/Grants:

Maintain liaison with sponsoring agencies and organizations as well as with other research and educational institutions.

Manage all or part of a research project including staff selection, assignment and scheduling, monitoring of project funds, coordination of data generation and analysis and identification, acquisition and use of equipment and facilities.

Participate in determining research priorities and planning programs of research.

Service:

Maintain effective working relationships with faculty, staff, students and the public.

Demonstrate respect for all members of the University community in the course of performing one’s duties and in response to administrators, supervisors, coworkers and customers.

Represent the interests of the University and of unit leadership in the use of resources to meet service and productivity demands within unit goals and budgets; strives to promote continual processes and quality improvement.

Seek opportunities to enhance one’s own professional knowledge, skills and abilities as they relate to one’s current position and/or to prepare for potential future roles and overall career development.

Train investigators and support staff and conduct continuing education.

Human Resources/Supervision:

Mentor graduate students, medical residents on research rotations and research assistants working in the lab or collaborating from other labs.

Provide functional and/or administrative supervision for staff.

Supervise adherence to safety and compliance guidelines when necessary.

Required Qualifications:

Doctorate degree in molecular biology, genetics or an equivalent professional degree, i.e. DDS or DVM is required.

Minimum of 3 years of post-doctoral relevant laboratory experience in hearing genetics or related field is required.

Ability to plan and execute a research study through some progressively independent research work.

Strong working knowledge of in vivo experimental procedures in rodent (mouse).

Strong working knowledge of hearing testing in rodent, such as: Auditory Brainstem Response (ABR) and Distortion Product Otoacoustic Emissions (DPOAE), noise overexposure.

Strong working knowledge of mouse inner ear surgery, relative to viral vector injection.

Strong working knowledge of the middle and inner ear anatomy and proficiency in harvesting, dissecting and preparing cochlear samples.

Strong working knowledge of cochlear morphology and sample preparation for various microscopy technics: such as Scanning and Transmission Electron Microscopy (SEM, TEM), confocal and light imaging.

Strong working knowledge of in vitro experiments involving bacteria and cell culture.

Strong working knowledge of molecular evaluation technics such as: PCR, RTqPCR, western blotting, Co-IP, immunofluorescence and of the associated equipment.

Experience genetic analysis technologies and analytical strategies.

Effective interpersonal skills required as well as written and oral communication and presentation skills.

Proficient computer skills including Graph pad Prism, Adobe illustrator, Photoshop, ImageJ as well as working knowledge statistical analysis.

Desirable Qualifications:

Strong working knowledge of plasmid construction.

Knowledge of University of Iowa Policies and Procedures.

Supervisory experience is highly desirable.

Position and Application Details

• Resume

Job openings are posted for a minimum of 7 calendar days and may be removed from posting and filled any time after the original posting period has ended.

Successful candidates will be required to self-disclose any conviction history and will be subject to a criminal background check and credential/education verification. Up to 5 professional references will be requested at a later step in the recruitment process.

For additional questions, please contact [e-mail].

Additional Information

• Classification Title: Asst Research Scientist/Engin
• Appointment Type: Professional and Scientific
• Schedule: Full-time

Compensation

Contact Information

• Contact Name: Ashley Nelson
• Contact Email: [e-mail]

Equal opportunity employer

The University of Iowa is an equal opportunity employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, religion, national origin, age, sex, pregnancy (including childbirth and related conditions), disability, genetic information, status as a U.S. veteran, service in the U.S. military, sexual orientation, or associational preferences.

Persons with disabilities who need assistance or accommodations with the application or interview process may contact University Human Resources/Faculty and Staff Disability Services, [phone] or [e-mail] . For jobs in UI Health care, please contact UI Health care Leave & Disability Administration at 319-356-7543 .

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