Associate Staff Scientist, iPSC Intestinal Organoids

Cincinnati Children's Hospital Medical Center; Cincinnati (OH); On-site; USD 110,000 - 150,000; Full time

Job summary

Cincinnati Children's Hospital Medical Center seeks an Associate Staff Scientist for the CuSTOM Accelerator to advance human organoid platforms and disease models. You will lead iPSC-derived intestinal organoid development, optimize protocols, and collaborate across disciplines to translate organoid research into regenerative medicine applications.

The role emphasizes independent research, leadership in a multidisciplinary team, and contribution to scalable organoid manufacturing and

Qualifications

• PhD in Biology, Bioengineering, Developmental Biology, Stem Cell Biology, Biomedical Engineering, or related field.
• Strong background in developmental biology, stem cell biology, tissue engineering, regenerative medicine, intestinal biology, or advanced in vitro models.
• Experience with iPSCs, organoid models, and mammalian cell culture.
• Experience with molecular, cellular, and imaging‑based characterization techniques.
• Ability to design and execute independent research projects.
• Excellent written and verbal communication, and collaborative/teamwork skills.

Responsibilities

• Lead development, optimization, and characterization of iPSC-derived intestinal organoid models for disease modeling and translational work.
• Establish protocols for stem cell differentiation, organoid culture, maturation, and functional assessment.
• Investigate intestinal development, epithelial regeneration, and tissue maturation using human stem cell‑derived systems.
• Contribute to preclinical evaluation of stem cell‑derived tissues and regenerative medicine strategies.
• Characterize organoid models using molecular, cellular, biochemical, imaging, and functional methods.
• Design, execute, analyze, and interpret experiments independently.
• Collaborate with developmental biology, bioengineering, automation, imaging, data science, surgery, and translational medicine experts.
• Develop scalable and automated organoid manufacturing and screening workflows.
• Present findings at meetings and conferences; prepare manuscripts and grant applications.
• Mentor junior scientists and laboratory personnel; build collaborations with academics, industry, and regulators.

Skills

iPSC-derived organoids

Mammalian cell culture

Molecular assays

Imaging techniques

Flow cytometry

Confocal microscopy

Data analysis

Interdisciplinary collaboration

Project management

Education

PhD in Biology or related field

Tools

Laboratory automation platforms

High-throughput screening

Organoid culture automation

Organoid and tissue engineering tools

Python/R/ MATLAB (optional)

Job description

Cincinnati Children's Hospital Medical Center seeks an Associate Staff Scientist for the CuSTOM Accelerator to advance human organoid platforms and disease models. You will lead iPSC-derived intestinal organoid development, optimize protocols, and collaborate across disciplines to translate organoid research into regenerative medicine applications.

The role emphasizes independent research, leadership in a multidisciplinary team, and contribution to scalable organoid manufacturing and