Associate Scientist, Viral Vector & Discovery Platform (GBMB02-0163)

Tscanrx; Waltham (MA); On-site; USD 80,000 - 100,000; Full time

Job summary

A clinical-stage biotech in Waltham is seeking an Associate Scientist for their Viral Vector & Discovery Platform team. The role involves executing lentivirus packaging, conducting QC experiments, and supporting target validation. Ideal candidates will have experience in gene editing, molecular biology, and thrive in a collaborative environment.

Qualifications

• 5-7+ years with Master’s or 8+ years with Bachelor’s in biotech or pharma.
• Expertise with lentivirus- and retrovirus-based cell transduction.

Responsibilities

• Organize and execute high-titer lentivirus packaging and purification.
• Lead efforts towards technology improvement and development.

Skills

Communication

Analytical Skills

Trouble-shooting

Education

Master’s degree

Bachelor’s degree

Tools

CRISPR

Western blot

ELISA

qPCR

flow-cytometry

Job description

Associate Scientist, Viral Vector & Discovery Platform (GBMB02-0163)

LOCATION:Waltham, MA

Position Summary:

TScan Therapeutics is a clinical-stage biotech seeking to revolutionize life-changing therapeutics for patients by identifying novel T cells and epitopes. We are looking for an experienced researcher to join our team as an Associate Scientist in the Viral Vector & Discovery Platform team, supporting our novel target identification and validation workflow in-house. The ideal candidate should have relevant experience in lentivirus and retrovirus-based cell transduction and engineering, CRISPR-based gene editing, basic molecular biology skills, and enjoy a fast-paced, collaborative, and vibrant startup culture. A team player with a sense of urgency will thrive in this role.

Responsibilities:

• Organize, plan, and execute small and large scale high-titer lentivirus packaging and purification tasks to support the company’s high-throughput discovery projects and target/TCR validation
• Execute RNA and protein-based QC experiments to monitor and ensure the quality of lentivirus generated in-house
• Lead group efforts towards technology improvement and development
• Keep track of DNA vector usage for research use
• Support DNA cloning and propagation efforts when necessary
• Manage and develop Viral Vector & Discovery Platform team

Requirements:

• Master’s degree with 5-7+ years OR Bachelor’s degree with 8+ years of relevant experience in the biotech or pharmaceutical industry
• Prior experience in a research core lab a plus
• Demonstrate expertise with lentivirus- and retrovirus-based cell transduction and engineering
• Excellent written and verbal communication skills, with the ability to document experiments in an organized and timely fashion and to present scientific data to coworkers
• Strong analytical and trouble-shooting skills
• Experience with various CRISPR-based gene editing techniques
• Hands-on experience with basic molecular biology, cloning, Western blot, ELISA, qPCR, luciferase assays, basic flow-cytometry
• Ability to work efficiently both independently and in a collaborative team environment and to quickly pivot and adapt with any changing priorities
• Additional preferred skills include experience with transposon-based genome engineering, primary T cell culture and editing, advanced primary human cancer and normal cell culture model (organoid, spheroid) experience, and familiarity with high-throughput genetic screening and novel assay development

About TScan:

TScan Therapeutics is a fully integrated, next-generation TCR-T cell therapy company. Founded in 2018, TScan’s platform was developed by Stephen Elledge, Ph.D., and Tomasz Kula, Ph.D., at Brigham and Women’s Hospital and Harvard Medical School. TScan’s transformative platform enables rapid discovery of TCRs and targets for engineered T cell therapy. This technology is extremely versatile and is applicable across multiple therapeutic areas beyond cancers, including autoimmune disorders and infectious diseases.

Do YOU have the anatomy of a TScanner?

Our talented, compassionate, and intelligent team is what makes TScan a Top Place to Work (as ranked by The Boston Globe). Our state-of-the-art offices with over 70,000 square feet of premium lab space, including an internal GMP manufacturing suite, are an environment that supports innovation, camaraderie, and professionalism. We are passionate, fun, flexible, and team oriented. Sound like you? Apply today.

EEO Statement

TScan is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate. TScan provides reasonable accommodations to qualified applicants and employees with disabilities. To begin an interactive dialogue with TScan regarding a reasonable accommodation in connection with the hiring process and/or to perform the responsibilities of the position for which the applicant has applied, please contact the recruiter.

Recruitment & Staffing Agencies

TScan Therapeutics does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to TScan Therapeutics or its employees is strictly prohibited unless contacted directly by TScan Therapeutics’ internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of TScan Therapeutics, and TScan Therapeutics will not owe any referral or other fees with respect thereto.