Associate Scientist, Post Doc Fellow- Quantitative Pharmacology and Pharmacometrics

Merck; West Point (PA); Sur place; USD 82 000 - 92 000; Plein temps

Avantages offerts par ce poste

Annual bonus

Long-term incentive

Résumé du poste

Merck's Postdoctoral Research Fellow Program invites early-career scientists to advance translational pharmacology in a collaborative, industry-focused setting.

As a Postdoctoral Research Fellow in Quantitative Pharmacology and Pharmacometrics, you will develop and apply PK/PD models, translate findings across populations, support pediatric drug development, and contribute to publications with mentorship from senior scientists.

Qualifications

• Experience with pharmacokinetic modeling (e.g., population PK [popPK] modeling, physiologically-based pharmacokinetic [PBPK] modeling).
• Proficiency in at least one programming language or pharmacometrics application (e.g., R, MATLAB, Python, NONMEM, Monolix, Phoenix WinNonlin, or other language).
• Scientific writing skill, demonstrated by publication record (includes preprints).

Responsabilités

• Reviewing and curating relevant nonclinical and clinical pharmacokinetic data from published and internal sources.
• Integrating data from multiple sources to support quantitative model development, evaluation, and application.
• Developing and qualifying fit-for-purpose pharmacokinetic and translational models to address questions in pediatric drug development.
• Evaluating model performance and uncertainty and translating results into recommendations for multidisciplinary project teams.
• Present your research at conferences and/or publish in peer-reviewed journals.

Connaissances

Pharmacokinetic modeling

Programming (R/Python/MATLAB)

Scientific writing

Pediatric PK translation

PBPK modeling

Formation

Ph.D. in pharmacometrics or related field

Outils

R

Python

NONMEM

Monolix

Phoenix WinNonlin

Description du poste

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories' Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Position Overview

Scientific Question Half-life extended or Fc-modified biologics offer important opportunities to improve the prevention and treatment of disease, including in pediatric populations. Translating pharmacokinetic knowledge across populations remains scientifically challenging and requires fit-for-purpose quantitative approaches. The goal of the project is to advance translational pharmacokinetic modeling to support pediatric exposure prediction and dose selection using available nonclinical and clinical data. This project will focus on developing and applying quantitative modeling approaches to address key questions in pediatric drug development. The research will generate broadly applicable scientific insights, strengthen model-informed decision-making, and support the development of long-acting therapeutics.

That's where you come in...

What is the Position?

As a Postdoctoral Research Fellow in Quantitative Pharmacology and Pharmacometrics, you will work with a collaborative team of scientists in quantitative pharmacology, preclinical ADME, translational PK/PD, and discovery biology. You will develop and apply quantitative pharmacology models to characterize pharmacokinetics, support translation across populations, and inform pediatric development. You will evaluate model assumptions and uncertainty, integrate data from multiple sources, and communicate findings to multidisciplinary research teams. All Postdoctoral Research Fellows work with a dedicated mentor, collaborate with experienced scientists, and are fully integrated into the larger Quantitative Pharmacology and Pharmacometrics group.

Responsibilities

• Reviewing and curating relevant nonclinical and clinical pharmacokinetic data from published and internal sources;
• Integrating data from multiple sources to support quantitative model development, evaluation, and application;
• Developing and qualifying fit-for-purpose pharmacokinetic and translational models to address questions in pediatric drug development;
• Evaluating model performance and uncertainty and translating results into recommendations for multidisciplinary project teams;
• Present your research at conferences and/or publish in peer-reviewed journals.

Education Requirement

• Must currently hold a Ph.D. OR
• Receive a Ph.D. no later than spring 2027
• Ph.D. in mathematical biology, systems biology, statistics / biostatistics, mathematics / applied mathematics, computer science, computational biology / chemistry, pharmacokinetics and pharmacodynamics, pharmacometrics, chemical / biomedical engineering, or a related field.

Required Experience and Skills

• Experience with pharmacokinetic modeling (e.g., population PK [popPK] modeling, physiologically-based pharmacokinetic [PBPK] modeling);
• Proficiency in at least one programming language or pharmacometrics application (e.g., R, MATLAB, Python, NONMEM, Monolix, Phoenix WinNonlin, or other language);
• Scientific writing skill, demonstrated by publication record (includes preprints).

Preferred Experience and Skills

• Knowledge of monoclonal antibody pharmacokinetic properties, respiratory viruses, pediatric pharmacology, translational modeling, or biologics drug development;
• Experiencing modeling preclinical or clinical pharmacokinetics of monoclonal antibodies;
• Experience working in multidisciplinary teams that include clinicians and biologists.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

postdoctoralopportunities

The salary range for this role is: $82,000-$92,000

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and ot