Associate Scientist, Post Doc Fellow- Quantitative Pharmacology and Pharmacometrics

Biopharma Careers; Pennsylvania; Hybrid; USD 82,000 - 92,000; Full time

Job summary

Merck & Co., Inc. Rahway, NJ, USA invites applications for a Postdoctoral Research Fellow in Quantitative Pharmacology and Pharmacometrics. You will develop PK/PD models to translate data across populations and support pediatric drug development in a collaborative team.

The role requires a Ph.D. by spring 2027 and PK modeling experience; there is mentoring, conference presentations, and opportunities to publish in peer-reviewed journals within a large biopharma setting.

Qualifications

• Must currently hold a Ph.D. or receive one no later than spring 2027.
• Experience with pharmacokinetic modeling (popPK / PBPK).
• Proficiency in at least one programming language or pharmacometrics application (R, MATLAB, Python, NONMEM, Monolix, Phoenix WinNonlin, or other).
• Scientific writing ability demonstrated by publications.

Responsibilities

• Review and curate nonclinical and clinical PK data from published and internal sources.
• Integrate data from multiple sources to develop and evaluate quantitative models.
• Develop and qualify fit-for-purpose PK and translational models for pediatric drug development.
• Evaluate model performance and uncertainty; translate results for multidisciplinary teams.
• Present research at conferences and publish in peer-reviewed journals.

Skills

ADME

Data Analysis

Pharmacodynamics

Pharmacokinetics

Pharmacology

Programming Languages

Scientific Research

Scientific Writing

Statistical Analysis

Education

PhD in Pharmacokinetics / Pharmacology / Pharmacometrics / Math / CS / related field

Tools

R

MATLAB

Python

NONMEM

Monolix

Phoenix WinNonlin

Job description

**Job Description****Be a part of the legacy: Postdoctoral Research Fellow Program**Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.**Position Overview:****Scientific Question**Half-life extended or Fc-modified biologics offer important opportunities to improve the prevention and treatment of disease, including in pediatric populations. Translating pharmacokinetic knowledge across populations remains scientifically challenging and requires fit-for-purpose quantitative approaches. The goal of the project is to advance translational pharmacokinetic modeling to support pediatric exposure prediction and dose selection using available nonclinical and clinical data. This project will focus on developing and applying quantitative modeling approaches to address key questions in pediatric drug development. The research will generate broadly applicable scientific insights, strengthen model-informed decision-making, and support the development of long-acting therapeutics.That’s where you come in...**What is the Position?**As a Postdoctoral Research Fellow in Quantitative Pharmacology and Pharmacometrics, you will work with a collaborative team of scientists in quantitative pharmacology, preclinical ADME, translational PK/PD, and discovery biology. You will develop and apply quantitative pharmacology models to characterize pharmacokinetics, support translation across populations, and inform pediatric development. You will evaluate model assumptions and uncertainty, integrate data from multiple sources, and communicate findings to multidisciplinary research teams. All Postdoctoral Research Fellows work with a dedicated mentor, collaborate with experienced scientists, and are fully integrated into the larger Quantitative Pharmacology and Pharmacometrics group.**Responsibilities include but are not limited to:**Reviewing and curating relevant nonclinical and clinical pharmacokinetic data from published and internal sources;Integrating data from multiple sources to support quantitative model development, evaluation, and application;Developing and qualifying fit-for-purpose pharmacokinetic and translational models to address questions in pediatric drug development;Evaluating model performance and uncertainty and translating results into recommendations for multidisciplinary project teams;Present your research at conferences and/or publish in peer-reviewed journals.**Education Requirement:**Must currently hold a Ph.D. **OR**Receive a Ph.D. no later than spring 2027Ph.D. in mathematical biology, systems biology, statistics / biostatistics, mathematics / applied mathematics, computer science, computational biology / chemistry, pharmacokinetics and pharmacodynamics, pharmacometrics, chemical / biomedical engineering, or a related field.**Required Experience and Skills:**Experience with pharmacokinetic modeling (e.g., population PK [popPK] modeling, physiologically-based pharmacokinetic [PBPK] modeling);Proficiency in at least one programming language or pharmacometrics application (e.g., R, MATLAB, Python, NONMEM, Monolix, Phoenix WinNonlin, or other language);Scientific writing skill, demonstrated by publication record (includes preprints).**Preferred Experience and Skills:**Knowledge of monoclonal antibody pharmacokinetic properties, respiratory viruses, pediatric pharmacology, translational modeling, or biologics drug development;Experiencing modeling preclinical or clinical pharmacokinetics of monoclonal antibodies;Experience working in multidisciplinary teams that include clinicians and biologists.We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.postdoctoralopportunitiesThe salary range for this role is: $82,000-$92,000This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days**Additional location(s) Compensation Information:****Required Skills:**ADME, Data Analysis, Pharmacodynamics, Pharmacokinetics, Pharmacology, Programming Languages, Scientific Research, Scientific Writing, Statistical Analysis**Preferred Skills:**Current Employees apply HERECurrent Contingent Workers apply HERE**Search Firm Representatives Please Read Carefully**Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.**Employee Status:**Regular**Relocation:**Domestic**VISA Sponsorship:**Yes**Travel Requirements:**10%**Flexible Work Arrangements:**Hybrid**Shift:**Not Indicated**Valid Driving License:**No**Hazardous Material(s):**N/A**Job Posting End Date:**10/26/2026 **\\*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.****Requisition ID:**R421411