Associate Scientist, In vivo Pharmacology, Inflammation

BioSpace; South San Francisco (CA); On-site; USD 85,000 - 120,000; Full time

Benefits offered by this job

Retirement plan

Medical, dental & vision coverage

Life and disability insurance

Stock-based incentives

Job summary

Amgen is seeking an Associate Scientist in In vivo Pharmacology within the inflammation space. You will execute in vivo preclinical disease models and in vitro assays in vivarium and lab to support pipeline programs.

The role requires hands-on experience with in vivo techniques, flow cytometry, and a strong understanding of Immunology and inflammation biology. Collaboration, meticulous data handling, and the ability to work in a dynamic team are essential.

Qualifications

• Masters degree with 1 year of Immunology or related experience or Bachelors with 3 years of Immunology or related experience.
• Hands-on experience with in vivo techniques including dosing routes (i.v., i.p., p.o., i.n., i.t., r.o., i.d., s.c.), bleeds, necropsy and organ collection.

Responsibilities

• Perform hands-on in vivo work primarily in mice, possibly rats in the vivarium.
• Provide technical support for studies including dosing, sample collection, health checks and study setup.
• Work with Scientists to design and execute experiments and meet study timelines.
• Communicate results to the team and follow established protocols and safety procedures.
• Support in vitro assays as required and participate in weekend/evening dosing rotations if needed.

Skills

In vivo pharmacology

Immunology

Flow cytometry

Molecular biology

ELISA

GraphPad Prism

Excel

PowerPoint

Strong communication

Independent thinking

Education

Masters in Immunology

Bachelors in Immunology

Tools

GraphPad Prism

Excel

PowerPoint

Word

Job description

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Associate Scientist, In vivo Pharmacology, Inflammation

What You Will Do

Lets do this. Lets change the world. In this vital role you will work in a highly dynamic in vivo pharmacology team executing in vivo preclinical disease models and in vitro assays in the vivarium and lab supporting pipeline programs.

Key Responsibilities

• Perform hands-on in vivo work primarily mice, possibly rats in the vivarium daily.
• Provide technical support for studies, dosing, sample/tissue collection, health checks, study setup and take down.
• Work side-by-side with Scientists/Senior Scientists to execute and help design experiments.
• Run concurrent studies, stay organized and detail-oriented to meet study timelines
• Participate in weekend/evening dosing rotations as needed
• Support in vitro assays as required
• Communicate results to immediate team and follow established protocols and safety procedures
• Work in a flexible team-oriented environment. Weekend and evening work may be required.

What We Expect Of You

We are all different, yet we all use our unique contributions to serve patients. The Associate Scientist we seek is a driven, pro-active, independent, and enthusiastic scientist who wants to contribute to cutting edge science and serve patients in a highly productive team environment with these qualifications.

Basic Qualifications

• Masters degree and 1 year of Immunology or related experience
• OR
• Bachelors degree and 3 years of Immunology or related experience

Preferred Qualifications

• M.S. degree in Immunology or related disciplines, or B.S. degree with commensurate scientific / drug discovery experience and track record of scientific excellence and productivity.
• Strong understanding of Immunology and Inflammation biology and principles.
• Willingness and curiosity to learn and explore new areas of research.
• Significant experience designing and executing concurrent in vivo preclinical inflammation and autoimmune disease models. Experience with colitis (DSS, CD45RBhi T cell transfer, IL-10 KO), lupus (NZB/W, MRL-lpr, Imiquimod), and arthritis (CIA, CAIA), GvHD models preferred. Experience in Asthma, COPD, HS, PBC a plus.
• Hands-on experience with in vivo techniques including dosing route of administration (i.v., i.p., p.o., i.n., i.t., r.o., i.d., s.c.), bleeds (r.o., cheek, tail), necropsy (organ collection (intestine/colon, lung, lymphnodes, spleen, liver, kidney, skin), cardiac bleed, lung BAL collection).
• Hands-on experience in cellular, biochemical, histological, and molecular biology assay techniques (i.e. ELISA, MSD, quantitative RT-PCR, BCA protein measurements) preferred. Hands-on experience with multicolor flow cytometry including Spectral flow approaches and Immune cell populations is essential.
• Computer literacy, especially proficiency with GraphPad Prism, Excel, PowerPoint and Word.
• Attention to detail, excellent organizational and communication skills, accurate & timely record keeping and data analysis are essential.
• Demonstrated track record of independent critical thinking and scientific achievement.
• Demonstrated experience in pharmacology and in vivo models of inflammation/Immunology.

What You Can Expect Of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In Addition To The Base Salary, Amgen Offers a Total Rewards Plan, Based On Eligibility, Comprising Of Health And Welfare Plans For Staff And Eligible Dependents, Financial Plans With Opportunities To Save Towards Retirement Or Other Goals, Work/life Balance, And Career Development Opportunities That May Include

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Equal Opportunity Employer

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.