Associate/Scientist, In Vivo Pharmacology

Simcere Pharmaceutical Group; Cambridge (MA); On-site; USD 80,000 - 130,000; Full time

Benefits offered by this job

Competitive compensation

Medical insurance

401(k)

Paid maternity leave

Paid paternity leave

Disability insurance

Job summary

A leading pharmaceutical company in Cambridge, MA is seeking a highly motivated scientist to join their in vivo pharmacology team. The candidate will be responsible for conducting preclinical research and developing models in oncology and CNS disorders. A Ph.D. in a relevant field and hands-on experience with rodent models are essential. The company offers competitive compensation, a collaborative culture, and opportunities for career development.

Qualifications

• Conducting preclinical research for novel therapeutic development.
• Independently perform in vivo efficacy studies.
• Familiarity with IACUC protocols and guidelines.

Responsibilities

• Design and conduct in vivo pharmacology studies.
• Develop and validate disease models for new compounds.
• Analyze and present data to project teams.

Skills

Hands-on experience in rodent models

Strong skills in dosing techniques

Strong record-keeping and documentation

Excellent organization skills

Familiarity with PK/PD principles

Experience with immunodeficient mice

Education

Ph.D. in Pharmacology, Immunology, Cancer Biology

M.S. with significant industry experience

Tools

Microsoft Office

GraphPad Prism

Job description

Simcere Pharmaceutical Group provided pay range

This range is provided by Simcere Pharmaceutical Group. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.

Base pay range

$80,000.00/yr - $130,000.00/yr

About Simcere:

Simcere Pharmaceutical Group is an innovation-driven pharmaceutical company committed to "For patience, for life." Our core therapeutic areas include oncology, central nervous system (CNS) disorders, autoimmunity, and infectious diseases. We are continuously expanding into areas with significant unmet medical needs. Our Cambridge, MA site is dedicated to cutting-edge research aligned with the company strategic directions.

Job Summary:

We are seeking a highly motivated and detail-oriented scientist to join our dynamic in vivo pharmacology team. The ideal candidate will play a critical role in conducting preclinical research to support novel therapeutic development in oncology, autoimmune diseases, and central nervous system (CNS) disorders. You will design, execute, and interpret in vivo studies, contributing to the mechanistic understanding of drug candidates and the progression of assets through the discovery pipeline.

Responsibilities:

• Design and conduct in vivo pharmacology studies in rodent models relevant to oncology, autoimmune, and CNS disease.
• Develop and validate disease models to assess efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of new compounds. Perform routine animal handling procedures and injections (SC, IP, IV, IM).
• Collaborate closely with medicinal chemistry, biology, and translational science teams to optimize therapeutic strategies.
• Analyze and present data to cross-functional project teams, contributing to candidate selection and IND-enabling studies.
• Maintain detailed electronic records, ensuring quality and compliance with institutional animal care guidelines.
• Independently perform in vivo efficacy studies utilizing xenograft models of immuno-oncology.
• Conduct bioluminescent imaging to detect and measure tumor growth and treatment efficacy. Analyze bioluminescent imaging for various studies.
• Perform cell-based testing, including maintenance and plating of cell lines and primary cells to support ongoing in vivo studies
• Provide general laboratory assistance, including laboratory equipment maintenance, ordering, and organizing supplies.

Qualifications:

• Ph.D. in Pharmacology, Immunology, Cancer Biology, or a related field; or M.S. with significant industry experience.
• Hands-on experience in rodent models of cancer, autoimmune disease, and/or CNS disease.
• Familiarity with PK/PD principles and assay development.
• Strong skills in dosing techniques (SC, IP, IV), tissue collection, and biomarker analyses (ELISA, flow cytometry, histology)
• Preferred familiarity with Microsoft Office, GraphPad Prism for necessary data entry, analysis, and presentations
• Strong record-keeping and data documentation skills. Excellent organization and communication skills and ability to collaborate effectively.
• Candidate must be familiar with IACUC protocols and guidelines
• Familiarity with IVIS bioluminescence imaging.
• In vitro experience in handling and propagating primary cells.
• Ex vivo experiences to support characterization of cell therapies (e.g. ELISA, Flow Cytometry).
• Experienced in working with immunodeficient mice such as (NSG mice). genetically engineered models and/or humanized mouse system.

What We Offer

• Opportunity to contribute to cutting-edge research targeting unmet clinical needs.
• Collaborative culture with access to innovative technologies and diverse expertise.
• Competitive compensation and benefits package.
• Continuous learning and career development opportunities.

Seniority level

• Seniority level

  Associate

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research

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Inferred from the description for this job

Medical insurance

Vision insurance

401(k)

Paid maternity leave

Paid paternity leave

Disability insurance

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