Principal Scientist

OneDigital NorCal HR Consulting; San Carlos (CA); On-site; USD 185,000 - 215,000; Full time

Job summary

A biotechnology firm is seeking a Principal Scientist to lead antibody discovery efforts. This role requires significant experience in in vitro techniques and previous leadership in a scientific setting. Ideal candidates will have a Master's or PhD in Biology along with strong problem-solving and communication skills. The position is full-time and located in San Carlos, CA.

Qualifications

• Master’s with 10+ years or PhD with 8+ years in antibody discovery.
• Experience in in vitro antibody discovery.
• Strong organization skills for managing multiple projects.

Responsibilities

• Lead Attobody discovery campaigns using various technologies.
• Manage data analysis and document findings accurately.
• Coordinate with outside vendors for protein production.

Skills

In vitro antibody discovery display technologies

Phage and yeast display

Sanger sequence analysis

Problem-solving

Communication skills

Education

Master’s degree in biology or related field

PhD in Biology or related field

Tools

Carterra LSA

Biacore SPR

Octet BLI

Flow cytometry (iQUE)

GraphPad Prism

Geneious

Benchling

Job description

OneDigital NorCal HR Consulting provided pay range

This range is provided by OneDigital NorCal HR Consulting. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.

Base pay range

$185,000.00/yr - $215,000.00/yr

**Posting for our client, Isotovia Biosciences **

We are looking for an outstanding Principal Scientist to join our Discovery team at Isotovia Biosciences, a new company in San Carlos. This individual will be a part of an integrated highly motivated team developing Attobody-based therapeutic molecules. As a vital member, the successful candidate will play a key role in building the foundation of the company’s Discovery organization. This is an on-site position.

Key Responsibilities:

• Responsible for Attobody discovery campaign using yeast and phage display technology, including design, execution and troubleshooting.
• Perform hands-on Attobody discovery workflow, from library construction, library panning, output screening, single clone attobody characterization and data analysis.
• Antibody characterization includes affinity and specificity determination, epitope binning and cell binding.
• Document and maintain ELN (Benchling) with accuracy in a timely manner
• Oversee outside vendors in matters related to protein production and characterization
• Conduct in-depth data analysis, communicate data efficiently in project meetings in line with project timeline and goals.
• Evaluate and assess new technologies and processes that could improve and streamline the discovery workflow.
• Analyze and interpret data, identify problems, and develop troubleshooting strategies.
• Proactively review scientific literature and provide strategic input and generate ideas for project
• Assesses the needs of a technology platform or Isotovia program and coordinates activities over multiple functions to fulfill company objectives and program goals.
• Performs other duties as assigned

Basic Qualifications:

• Master’s degree in biology or related field with a minimum of 10 plus years' experience in antibody discovery
• OR a PhD in Biology or related field with a minimum of 8 years' experience in antibody discovery
• Demonstrated ability to use and design in vitro antibody discovery display technologies (e.g., phage, yeast display) for discovery and/or engineering
• Sanger sequence analysis experience
• Excellent organizational skills and the ability to manage multiple projects simultaneously
• Demonstrated productivity and scientific independence with strong problem-solving skills.
• Desire to work in a dynamic startup environment is essential.

Preferred Qualifications:

• Strong communication skills to work within a multidisciplinary team environment.
• Direct experience with Carterra LSA, Biacore SPR, Octet BLI and flow cytometry (iQUE)
• Experience with robotic liquid handling systems is a plus.
• Knowledgeable in recombinant protein production and characterization
• Proficiency in GraphPad Prism, Geneious and Benchling
• Demonstrated track record in managing multiple projects and prioritizing tasks to meet

schedules and timelines.

• Excellent written and oral communication skills and the ability to present effectively to teams.
• Proven contribution to therapeutic antibody development and selection is desirable.

Salary range:

• $185,000-$215,000. The final salary offered is dependent on factors that may include but are not limited to the type and length of experience within the industry, education, etc.

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Science

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