Associate Scientist II, Analytical Sciences

Alnylam Pharmaceuticals, Inc.; Cambridge (MA); On-site; USD 68,000 - 101,000; Full time

Job summary

Alnylam Pharmaceuticals, Inc. in Cambridge, MA is seeking an Associate Scientist II for the Annealing and Testing group. The role focuses on QC of single-stranded RNA using HPLC and MS, and formulation of siRNA test articles for research support across therapeutic areas.

Onsite at 675 W. Kendall St., the candidate will prepare samples, perform analyses, and ensure data quality. The position requires a BS in Chemistry or Biochemistry with 0–3 years of experience, strong documentation practices,

Qualifications

• BS in Chemistry, Biochemistry or related discipline with 0–3 years of work experience.
• Experience with analytical instrumentation such as HPLC, LCMS, UV-VIS is required.
• Complete record-keeping and excellent laboratory documentation practice (electronic notebook) is required.

Responsibilities

• Prepare analytical samples for testing.
• Analyze synthetic RNA using HPLC and MS to confirm identity and determine purity.
• Formulate and perform quality analysis of siRNA test articles by LCMS, UV spectroscopy and osmometry.
• Perform Bacterial Endotoxin Test (BET).
• Collaborate cross-functionally to meet timelines and present data.

Skills

Analytical mindset

Team collaboration

Documentation

Communication

Education

BS in Chemistry/Biochemistry or related

Tools

HPLC

LCMS

UV-VIS

Osmometry

Job description

OverviewThe RNAi Discovery team is seeking a motivated individual to join our Annealing and Testing group as an Associate Scientist II. The Annealing and Testing group is responsible for the quality control of single stranded RNA using analytical techniques such as liquid chromatography and mass spectrometry. In addition, the group is responsible for formulating high quality test articles (siRNA) to support research efforts across multiple therapeutic areas.This position is onsite and will be located at our 675 W. Kendall St. location in Cambridge, MA.ResponsibilitiesPreparation of analytical samples.Analysis of synthetic RNA using analytical techniques such as HPLC and MS, to confirm identity and determine purity of product.Formulation and quality analysis of test articles (siRNA), by LCMS, UV spectroscopy and osmometry.Perform Bacterial Endotoxin Test (BET).Work closely with the team and cross-functionally to ensure required timelines are met.Organize, analyze and interpret data for presentations to team members and larger audiences within the research organization.Provide analytical support for various groups across research and early development, as needed.QualificationsBS Chemistry, Biochemistry or related discipline with 0-3 years of work experience.Experience with analytical instrumentation such as HPLC, LCMS, UV-VIS is required.Excellent written and oral communication skills, good organization skills, the ability to multitask, and the ability to work within a team and/or independently are required.Complete record-keeping and excellent laboratory documentation practice (electronic notebook) are required.#LI-JR1U.S. Pay Range$67,600.00 - $101,400.00The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careersAbout AlnylamWe are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.