Associate Scientist II

Meet Life Sciences Ltd.; San Carlos (CA); On-site; USD 85,000 - 110,000; Full time

Job summary

Meet Life Sciences Ltd. in the United States is seeking an Associate Scientist II to support protein purification and chromatography process development within a Research organization, on a 12-month contract focused on vaccine antigen development.

The role requires hands-on experience with IMAC, IEX, HIC, SEC and hydroxyapatite, plus design of experiments, data handling, and collaboration with cross-functional teams. Strong AKTA FPLC skills are essential to optimize purification strategies.

Qualifications

• Bachelor's degree with 2+ years industry experience or Master's with 1+ year experience.
• Hands-on experience with IMAC, IEX, HIC, SEC and hydroxyapatite chromatography.
• Strong experience with AKTA FPLC systems and DoE approaches.

Responsibilities

• Perform IMAC, IEX, HIC, SEC, and hydroxyapatite chromatography techniques.
• Design chromatography trains using complementary modalities to reduce impurities.
• Support chromatography selection, screening, development, scale-up, and characterization activities.
• Utilize membrane chromatography for high-throughput contaminant removal and virus/VLP processing.
• Support multimodal chromatography optimization and process development activities.
• Apply Design of Experiments (DoE) approaches to chromatography development and optimization.
• Maintain accurate and up-to-date records of experiments in an electronic notebook.
• Analyze experimental data and present findings to the Research team.
• Collaborate with scientists and cross-functional team members to support research initiatives.
• Provide additional technical and experimental support as needed.

Skills

Multiple chromatography modalities

DoE for chromatography development

AKTA FPLC operation

Education

Bachelor's degree in Biochemistry, Molecular Biology, or related field

Master's degree in related field

Tools

AKTA FPLC systems

ELN experience

Job description

Seeking an experienced Associate Scientist II to support protein purification and chromatography process development within a Research organization. This is a 12-month contract opportunity supporting the development and characterization of vaccine antigens. The ideal candidate will have hands-on experience with diverse chromatographic modalities, including IMAC, IEX, HIC, SEC, and hydroxyapatite, along with experience in protein purification, process development, and chromatography optimization.

Key Responsibilities

• Perform IMAC, ion-exchange chromatography (IEX), hydrophobic interaction chromatography (HIC), size-exclusion chromatography (SEC), and hydroxyapatite (CHT/HA) techniques.
• Design chromatography trains using complementary modalities to reduce host cell proteins, endotoxin, aggregates, and other impurities.
• Support chromatography selection, screening, development, scale-up, and characterization activities.
• Utilize membrane chromatography for high-throughput contaminant removal, virus/VLP processing, and scale-friendly polishing or scavenging applications.
• Support multimodal chromatography optimization and process development activities.
• Apply Design of Experiments (DoE) approaches to chromatography development and optimization when applicable.
• Maintain accurate and up-to-date records of experiments and project activities within an electronic laboratory notebook.
• Analyze experimental data and present findings to the Research team.
• Contribute to technical discussions and troubleshoot chromatography and purification challenges.
• Collaborate effectively with scientists and cross-functional team members to support research initiatives.
• Provide additional technical and experimental support as needed.

Required Skills

• Bachelor's degree in Biochemistry, Molecular Biology, or a related scientific discipline with 2+ years of relevant industry experience; or Master's degree with 1+ year of relevant industry experience.
• Hands-on experience with multiple chromatography modalities beyond traditional monoclonal antibody/Protein A workflows.
• Strong experience with AKTA FPLC chromatography systems.
• Experience with IMAC, IEX, HIC, SEC, and/or hydroxyapatite chromatography.
• Experience working with diverse protein targets, including bacterial and e