Advisor/Sr. Advisor - Bioconjugation Scientist

100 Eli Lilly and Company; United States; On-site; USD 129,000 - 209,000; Full time

Benefits offered by this job

401(k)

Pension

Vacation benefits

Medical benefits

Dental benefits

Vision benefits

Flexible benefits

Life insurance

Well-being programs

Job summary

Lilly in the United States seeks a Scientist to facilitate bioconjugation transfers from development to manufacturing, including ADC processes and kilo-scale operations. You will mentor junior scientists and work cross-functionally with engineers, analytical chemists, safety and quality teams.

Initial location at Lilly Technology Center, Indianapolis, with permanent placement at the Lebanon, Indiana facility; some travel may be required.

Qualifications

• Experience in bioconjugation chemistry for ADCs.
• Experience with kilo-scale to pilot plant manufacturing.
• Ability to lead technology transfer end-to-end.
• Strong analytical data interpretation and documentation.

Responsibilities

• Facilitate transfer of bioconjugation processes to manufacturing.
• Lead and mentor junior scientists.
• Ensure plant readiness and safety compliance.
• Collaborate across disciplines to transfer processes.

Skills

Bioconjugation chemistry

ADC development

Antibody handling

Conjugation strategies

Mentoring

Cross-functional collaboration

Process transfer

Education

Biochemistry, chemical biology, or chemical engineering degree

PhD in a related field with 2+ years of experience

Tools

RP-HPLC

SEC

IEX

HIC

LC-MS

CE-SDS

Bioconjugate purification

Job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life‑changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Overview: At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader, headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life‑changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Lilly recently announced a $4.5 billion investment to create the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development, Lebanon, Indiana. The first‑ever facility of its kind, combining research and manufacturing in a single location, the Medicine Foundry will allow Lilly to further develop innovative solutions to optimize manufacturing processes and increase capacity for clinical trial medicines, while also reducing costs and environmental impact. The Process Translation and Execution (PTE) team translates API/DS process knowledge into clinical supply readiness, oversees technology transfer, implements phase‑appropriate control strategies, and ensures right‑first‑time clinical manufacturing for a variety of modalities, including synthetic molecules, biologics, peptides, oligonucleotide, and bioconjugates (ADC, ARC, etc.). Through cross‑functional collaboration, PTE influences process design, revolutionizes clinical manufacturing, builds capabilities in emerging technologies and aligns with corporate and Lilly Research Labs (LRL) goals, drives scientific excellence and innovation to accelerate manufacturing advancements and propels the site toward long‑term business success.

Responsibilities

In this role, the Scientist will be responsible with facilitating the transfer of chemical processes for bioconjugation process’ to produce ADCs and similar modalities, from development laboratories to pilot plant operations (including kilo‑scale and production environments), operating independently and guiding more junior scientists. This enables the successful transition to early‑phase cGMP manufacturing of grams to kilogram quantities of API required for clinical trial supply. Experience performing bioconjugation chemistry to form ADC’s including antibody preparation, buffer exchanges and protein specific characterization (DAR analysis, aggregate assessment…). Hands‑on experience across multiple conjugation strategies (maleimide, click, enzymatic). Experience working with highly potent molecules and containment in the lab and production environments as well as working with single‑use bioprocessing systems. Ability to mentor less experienced scientists and ultimately supervise colleagues. Ability to work cross‑functionally across disciplines and levels with engineers, analytical chemists, chemical technicians, safety and quality representatives. Actively involved in receiving chemistry from early phase process research and development labs and evaluating the safety of the incoming procedures in collaboration with the safety group and process engineering. Ensure raw material and reagent readiness, obtain reference materials, and participate in setting up analytical methods. Obtain reference materials and participate in setting up analytical methods. Reprocess and analyze analytical data to make fact‑based decisions. Efficient with summarizing and presenting chemistry and challenges. Perform familiarization reactions to ensure plant readiness of process steps including reduction/conjugation/oxidation reactions and Tangential Flow Filtration (TFF) operations at the Lilly Medicine Foundry. Perform use‑tests of key raw materials and document Definitive Lab Trials of processes to confirm plant readiness. Maintain a well‑organized and detailed lab notebook with accurate descriptions of the chemistry, observations, and organized analytical data to enable the preparation of technical packages/technical transfers and accurate replication in receiving labs. Documentation: Author, review technical documents, including tech transfer plan, standard operating procedures (SOPs), batch records, campaign summary reports, and deviation reports. Process improvement: Apply scientific knowledge to identify areas for improvement and implement new technologies or procedures. Contribute to process troubleshooting and investigations by supporting process deviations, quality events, and non‑conformances. Collaborate with teams to perform root cause analysis (RCA) and develop effective corrective and preventive actions (CAPAs).

Basic Requirements

• B.S. or M.S. in with 6+ years of experience or PhD with 2+ years of experience in manufacturing environments involving biochemistry, chemical biology, conjugation chemistry, chemical engineering or related field.

Additional Preferences

• Working knowledge of organic chemistry and mechanisms and application to reaction improvement and optimization.
• Knowledge of and hands‑on experience with analytical methods used for small molecules and biomolecules (RP‑HPLC, SEC, IEX, HIC, LC‑MS, CE‑SDS).
• Hands‑on experience with liquid chromatography: bioconjugate purification and familiarity with chromatography systems.
• Experience with synthetic chemistry techniques used for developing and scaling‑up chemical reactions.
• Experience using process chemistry concepts is a plus.
• Comfortable working with larger sized glass equipment as well as single use equipment.
• Demonstrated ability to independently lead a technology transfer end to end, from development lab to clinical manufacturing.
• Has experience creating batch records and conducting scale‑up experiments according to those records.
• Ability to prioritize multiple activities and manage ambiguity.
• Process quantification and acquiring mass balance for products and by‑products.
• Demonstrated ability to drive projects and accept change.

Communication Skills

• Excellent written and verbal communication skills for technical report writing, presentations, and effective collaboration across teams.

Problem‑Solving Skills

• Proven ability to analyze data, perform root cause analysis, and resolve complex technical challenges.
• Ability to work cross‑functionally across disciplines and levels with engineers, analytical chemists, chemical technicians, safety and quality representatives.

Other Information

Initial location at Lilly Technology Center, Indianapolis. Permanent location at the new Lilly Medicines Foundry in Lebanon, Indiana. Limited domestic and international travel (< 5%) may be required for this role. Role requires ability to work in manufacturing and laboratory environments.

EEO/Affirmative Action

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. #WeAreLilly Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees.

Employee Resource Groups (ERGs)

• Africa, Middle East, Central Asia (AMECA)
• Black Employees at Lilly (BE@Lilly)
• Chinese Culture Network (CCN)
• EnAble
• Evolve
• Lilly Indian Network (LIN)
• Organization of Latinx at Lilly (OLA)
• Pride (LGBTQ+ Allies)
• Veterans Leadership Network (VLN)
• Women’s Initiative for Leading at Lilly (WILL)

Compensation & Benefits

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $129,000 - $209,000. Full‑time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company‑sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well‑being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).

• company‑sponsored 401(k)
• pension
• vacation benefits
• medical benefits
• dental benefits
• vision benefits
• prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well‑being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people. We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe! #WeAreLilly