Associate Scientist, Discovery Biology

Soufflé Therapeutics; Watertown (MA); On-site; USD 70,000 - 95,000; Full time

Job summary

Soufflé Therapeutics in Watertown, MA is seeking an Associate Scientist to join the Discovery Biology team. You will perform cellular, molecular, and biochemical assays to support drug discovery, contribute to experimental planning, and document results with rigorous records.

The role emphasizes hands-on lab work in a fast-paced, collaborative environment with strong ownership and attention to data quality. Onsite with flexibility for collaboration.

Qualifications

• Requires Master of Science with 2+ years of experience or Bachelor of Science with 5+ years of experience.
• Hands-on expertise in cellular, molecular and biochemical assays for drug discovery.
• Experience with nucleic acid handling and tissue/cell extraction is preferred.

Responsibilities

• Perform nucleic acid extraction from tissues/cells and run high-throughput quantitative PCR.
• Optimize and establish robust sample processing methods for diverse tissue types.
• Summarize results, troubleshoot issues, and communicate findings clearly within group.
• Maintain rigorous sample tracking, chain-of-custody, and documentation in ELN.
• Contribute to general lab operations (inventory, reagents, organization, equipment upkeep).
• Support lab operations to keep studies running smoothly.

Skills

Cellular assays

Molecular assays

Biochemical assays

qPCR

dPCR

In situ hybridization

Immunofluorescent imaging

Flow Cytometry

Ex vivo workflows

In vivo exposure (assistance)

Education

Master of Science

Bachelor of Science (with 5+ years)

Job description

Soufflé Therapeutics is a biotech company focusing on the cell-type specific delivery of genetic medicines. It's team of driven scientists is making a mark in delivery of oligonucleotides to extrahepatic tissues. We thrive in a purpose-building lab and office space in Watertown. Come and join us in our quest!

Position Summary:

We are seeking an exceptional Associate Scientist to join our growing Discovery Biology team in the Greater Boston Area. The candidate’s primary role will be lab-focused and include a range of cellular, molecular and biochemical assays to support drug discovery efforts. The successful candidate will contribute to experimental planning and execution across ex vivo and in vitro workflows and will be comfortable operating in a fast-paced, highly collaborative environment where timelines matter and data quality is non-negotiable. This position demands strong technical ownership and excellent documentation habits.

Key Responsibilities

• Perform nucleic acid extraction from tissues/cells and run high-throughput quantitative PCR
• Optimize and establish robust sample processing methods for diverse tissue types to support assay development and validation
• Summarize results, troubleshooting issues, and communicate findings clearly within group and cross-functionally
• Maintain rigorous sample tracking, chain-of-custody, and documentation in ELN
• Contribute to general lab operations (inventory, reagents, organization, equipment upkeep) to keep studies running smoothly

What Success Looks Like

• In 3 months: Acquainted with our molecular biology workflows, protocols, and instrumentation
• In 6 months: Able to carry out routine lab work independently, with minimal supervision
• In 12 months: Independently troubleshoot issues and owning experimental projects with minimal oversight, with a mature understanding of how your work fits into Soufflé's broader efforts
• Enjoy working on a highly collaborative and fast-paced environment, multitasking, time-management, integrity as well attention to detail and curiosity.

Qualifications — Preferred

• Perform protein extraction from tissues/cells and support protein semi-/quantitative assays as needed (ex: Western, JESS, ELISA, MSD)
• Flow Cytometry
• Perform ex vivo workflows, including isolation and culture of primary cells from tissues and basic readouts
• Any in vivo exposure (role would potentially include helping with in vivo collections)
• One role is heavy(er) focus on quantitative PCR (including qPCR and dPCR)
• Second role is heavier focus on situ hybridization, Immunofluorescent imaging

Education

• Master of Science with 2+ years of experience or Bachelor of Science with 5+ years of experience

At Soufflé Therapeutics, we are intentional about building an equitable culture. How we treat our people is reflective of this focus. We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

This is an onsite position in Watertown, MA (US) with flexibility as needed for collaboration and external engagements.