Associate Principal Biopharmaceutics Scientist (SC)

MSD; Rahway (NJ); On-site; USD 142,000 - 224,000; Full time

Job summary

MSD in Rahway, NJ is seeking an Associate Principal Scientist to lead biopharmaceutics strategy for subcutaneously administered biologics across the development pipeline. You will work with formulation, analytical, device engineering, pharmacokinetics, and clinical pharmacology teams to apply mechanistic principles and quantitative modeling to optimize SC absorption, formulation, and device compatibility.

The role requires strong scientific rigor and matrix leadership to reduce clinical delivery

Qualifications

• PhD or MSc with extensive biologics drug product development experience.
• Deep knowledge of SC absorption, interstitial transport, and translational PK.
• Experience leading cross-functional matrix development teams.

Responsibilities

• Define integrated experimental and modeling strategies for formulation and device decisions.
• Translate preclinical findings to support formulation, device, and process changes.
• Evaluate immunogenicity risks and local tolerability related to delivery conditions.
• Communicate risks and recommendations at governance forums and regulatory submissions.
• Develop predictive tools and mentor scientists in translational biopharmaceutics.

Skills

Biopharmaceutics

Translational PK

Subcutaneous absorption

Regulatory submissions

Matrix leadership

Modeling and simulation

Regulatory strategy

Immunogenicity risk assessment

Education

PhD in Pharmaceutical Sciences

MS in a related field with industry experience

Tools

GastroPlus

Simcyp

Phoenix WinNonlin

PK-Sim

MATLAB

Python/R

Job description

MSD in Rahway, NJ is seeking an Associate Principal Scientist to lead biopharmaceutics strategy for subcutaneously administered biologics across the development pipeline. You will work with formulation, analytical, device engineering, pharmacokinetics, and clinical pharmacology teams to apply mechanistic principles and quantitative modeling to optimize SC absorption, formulation, and device compatibility.

The role requires strong scientific rigor and matrix leadership to reduce clinical delivery