Associate Medical Director, Clinical Development

BioSpace; Boston (MA); Hybrid; USD 242,000 - 314,000; Full time

Benefits offered by this job

Discretionary bonus

Long-term incentive (equity)

Hybrid work schedule

Job summary

Beeline Medicines in the United States seeks an Associate Medical Director, Clinical Development to provide medical leadership across diverse immunology trials, shaping study design, safety monitoring, data interpretation, and regulatory deliverables.

You will collaborate with cross-functional teams, contribute to development strategy, and engage with external experts. This hybrid role includes on-site days weekly with opportunities for leadership in a dynamic biotech environment.

Qualifications

• MD or DO; Board certification in rheumatology or related field preferred.
• Minimum 3 years pharma/biotech clinical development experience.
• Experience in lupus (SLE/CLE) or systemic sclerosis is strongly preferred.
• Deep expertise in autoimmune disease and immunology / inflammation.
• Ability to lead cross-functional teams in a fast-paced biotech environment.

Responsibilities

• Lead medical oversight for assigned trials including protocol development, study conduct, monitoring, data review and reporting.
• Contribute to clinical development strategy and program plans aligning scientific rationale with regulatory requirements.
• Provide medical leadership on trial design: endpoints, eligibility, dose rationale, biomarkers, monitoring and interim analyses.
• Monitor real-time data collection and ensure protocol adherence across studies.
• Support pharmacovigilance activities and safety governance in coordination with PV Medical Director.
• Engage external investigators, KMEs, and advisory boards; support scientific communications.
• Prepare and review protocols, amendments, investigator brochures, informed consent forms, and clinical study reports.

Skills

Medical leadership

Clinical development

Trial design

Regulatory understanding

Cross-functional collaboration

Communication skills

KME engagement

Travel flexibility

Education

MD or DO (Board certification)

MD/PhD considered

Tools

CTMS / clinical trial tools

Regulatory document workflows

Job description

About Beeline Medicines

Beeline Medicines is a clinical‑stage biotechnology company focused on developing and delivering category-leading precision therapies to transform the lives of people living with autoimmune and inflammatory diseases. With a portfolio of potential best-in-class and first-in-disease therapeutic candidates that directly target key pathways governing dysregulated immunological and inflammatory responses, the Company is developing medicines that have the opportunity to provide durable, life‑changing impact. Led by an established executive team and backed by world‑class life science investors, each day Beeline Medicines is determined to bring the scientific rigor and operational excellence to get to what matters for patients – realizing a world where people with immune‑mediated diseases can live life fully.

About Beeline Medicines

Beeline Medicines is a clinical‑stage biotechnology company focused on developing and delivering category‑leading precision therapies to transform the lives of people living with autoimmune and inflammatory diseases. With a portfolio of potential best‑in‑class and first‑in‑disease therapeutic candidates that directly target key pathways governing dysregulated immunological and inflammatory responses, the Company is developing medicines that have the opportunity to provide durable, life‑changing impact. Led by an established executive team and backed by world‑class life science investors, each day Beeline Medicines is determined to bring the scientific rigor and operational excellence to get to what matters for patients – realizing a world where people with immune‑mediated diseases can live life fully.

Job Summary

The Associate Medical Director, Clinical Development – is a therapeutic and disease area specialist who will play a key role in advancing innovative therapies for patients with immunology diseases through high‑quality design and execution of clinical trials. In this role, you will provide medical leadership across a range of clinical development activities, including but not limited to: study design, study execution, monitoring of patient safety, data interpretation, and contribution to regulatory and scientific deliverables. As an internal scientific leader in the field, you will provide input into the overall clinical development strategy for the asset and incorporate insights from key opinion leader interactions into both study design and development strategy. This role involves working closely with internal cross‑functional partners across a range of disciplines to drive high‑quality clinical programs in a fast‑paced biotech environment.

Work Arrangement & Location:

Hybrid – This position follows a hybrid work schedule, requiring a minimum of two (2) days on‑site per week — currently designated as Tuesday and Wednesday. Additional on‑site days may be required based on business needs, team priorities, or leadership direction.

Essential Duties And Responsibilities

• Lead and provide medical oversight for assigned clinical trials including; protocol development, study conduct, medical monitoring, data review & interpretation, and clinical study reporting.
• Contribute to clinical development strategy and program plans by integrating scientific rationale, regulatory requirements, safety considerations, operational feasibility, and business objectives.
• Provide medical leadership on trial design, including endpoint selection, eligibility criteria, dose rationale, biomarker strategy, risk‑based monitoring, and interim analysis frameworks.
• Monitor real time data collection throughout study conduct ensuring robust study conduct and protocol adherence.
• Support pharmacovigilance activities during trial conduct – monitor patient safety and benefit‑risk throughout study conduct through review of adverse events, serious adverse events, laboratory data, safety narratives, and aggregate safety information, and contribute to related safety governance activities in coordination with the Global PV Medical Director
• Serve as a key medical resource for investigative sites, external advisors, and clinical investigators, ensuring patients meet the appropriate eligibility criteria, responding to clinical and safety inquiries and supporting external interactions, advisory boards, and scientific communications as appropriate.
• Lead and conduct peer‑to‑peer scientific exchange with KMEs, investigators, and HCPs – sharing clinical and emerging data, discussing unmet medical needs, and gathering external insights that inform overall development strategy.
• Review, author, and contribute to key clinical and regulatory documents, including protocols, protocol amendments, investigator brochures, informed consent forms, clinical study reports, briefing materials, and health authority responses.
• Perform other duties and responsibilities as assigned

Qualifications

• Education: Advanced clinical degree (MD or DO) or MD/PhD required. Board certification or clinical training in rheumatology, nephrology, immunology, or a related specialty strongly preferred. Additional advanced degree (PhD, MPH, or MBA) is a plus.
• Minimum of 3 years of pharmaceutical / biotech industry experience or research / hospital setting in clinical development, medical monitoring, or drug safety; clinical practice experience in relevant specialty is highly valued.
• Direct experience treating, or managing lupus (SLE and/or CLE)and/or systemic sclerosis patients and clinical programs strongly preferred.
• Deep scientific expertise in autoimmune disease — rheumatology, specifically lupus (SLE and/or CLE) or systemic sclerosis, preferred.
• Deep clinical and scientific expertise in immunology and inflammation— including command of disease mechanisms, clinical trial landscapes, standard of care evolution, regulatory developments, and emerging therapeutic approaches
• Ability to lead and influence cross‑functional teams in a matrixed, fast‑paced biotech or pharmaceutical environment without direct line authority
• Ability to build alignment across diverse internal and external stakeholders, including senior leadership, clinical operations, regulatory, and commercial partners
• Track record of driving program‑level decisions with clarity and accountability, balancing scientific rigor with business urgency in resource‑constrained settings
• Experience fostering a culture of high performance, inclusion, and continuous learning
• Exceptional scientific communication skills, both written and verbal with the ability to articulate complex medical and clinical data to a range of internal and external stakeholders
• Occasional travel to medical congresses, KME meetings, advisory boards, and site engagements per business need

Salary Range

The expected salary range for this position varies by location and will be communicated based on the country or region in which the selected candidate is hired. Actual pay will be determined based on experience, qualifications, location, and other job‑related factors permitted by applicable local law. A discretionary annual bonus and long‑term incentive award (e.g., equity) may be available based on individual and Company performance.

Salary Range

$242,000 - $313,500 USD

Benefits

We offer a comprehensive benefits package tailored to the country and region in which you are hired, in compliance with local laws and practices. Benefits may include, but are not limited to:

• Competitive health and wellness coverage (structure and premiums vary by country)
• Paid time off, public holidays, and additional leave entitlements in accordance with local requirements
• Flexible work arrangements / hybrid schedule

Benefits vary by location and are subject to eligibility requirements, local regulations, and plan terms. Specific benefit details applicable to your country or region will be provided during the offer process.

Equal Employment Opportunity

Beeline Medicines is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity or expression, national origin, disability, age, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Reasonable Accommodation

If you require a reasonable accommodation to participate in the application or interview process, please contact [e-mail] to request an accommodation. We are committed to providing equal access to all candidates.

Privacy

Upon submission of this form I understand that Beeline Medicines is based in the United States and personal data submitted in the form will be transferred and accessed in the U.S., Information about Beeline Medicines privacy practices can be found at Privacy Policy - Beeline Medicines