Associate Manager Next-Generation Sequencing (NGS) Data Analysis

Regeneron Genetics Center (USA); Village of Tarrytown (NY); On-site; USD 110,000 - 179,000; Full time

Job summary

Regeneron Genetics Center in Tarrytown, NY seeks an Associate Manager of Sequencing Informatics Research to lead development of multi-omics informatics methods for PacBio, Illumina, Olink and Ultima platforms.

This role collaborates with Sequencing & Lab Operations and Production Informatics to onboard new platforms, advance base-calling, read mapping, and variant calling, and deliver scalable, industry‑grade software.

Qualifications

• Master’s (PhD preferred) in Bioinformatics or equivalent.
• 0–3 years of experience in sequencing informatics methodology (base calling, read mapping, variant calling).
• Experience with large-scale multi-omics data types (DNA-seq, RNA-seq, proteomics, methylation).
• Fluency with state-of-the-art bioinformatic tools and standards.
• Engagement in the sequencing bioinformatics community.

Responsibilities

• Lead the integration of state-of-the-art methods to create multi-omics informatics best-practices.
• Identify opportunities across sequencing modalities to increase actionability of results.
• Inform development of protocols for DNA-seq, RNA-seq, long-read sequencing, and proteomics.
• Collaborate with technology partners to improve base-calling, read mapping, and variant calling.
• Deploy novel methods into Regeneron’s Enterprise Research environment as industry-grade software.

Skills

Bioinformatics proficiency

Multi-omics handling

Base calling

Community engagement

Education

Master’s degree or PhD in Bioinformatics

Job description

The Regeneron Genetic Center's (RGC) Genome Informatics team is looking for an Associate Manager of Sequencing Informatics Research to serve as the lead scientist and developer for the RGC’s Sequencing Informatics research initiatives. This individual will contribute to development and design of sequencing informatics methods and protocols for new and existing multi-omics platforms, including PacBio, Illumina, Olink, and Ultima. These efforts will be driven by the goal to maximize value from RGC samples and data. Working closely with the Sequencing & Lab Operations and Production Informatics teams, this role will also assist the methods engagement with RGC’s technology partners to on-board new sequencing and informatics platforms and ensure they can meet the RGC’s unique scaling and analysis needs.

When & where:

Location: Tarrytown, NY

Work model/flexibility: 4 days onsite

Discover your role:

• Lead the integration of state-of-the-art and novel methods to create multi-omics informatics best-practices that increase value from RGC samples by lowering data requirements and leveraging RGC’s unique data resources
• Identify opportunities that combine multiple sequencing modalities (e.g., short-read, long-read, capture, genome, depth-based) to increase the actionability of RGC sequencing deliverables
• Inform development of novel sequencing informatics protocols to support multi-omics applications on existing and new sequencing platforms, including DNA-seq, RNA-seq, long-read sequencing, and proteomics
• Support RGC’s joint development efforts with technology partners (e.g. NVIDIA, Google Brain) to improve base-calling, read mapping, variant calling and harmonization through bioinformatics R&D
• Collaborate with RGC’s Genomics R&D, Engineering and Production teams to deploy novel methods into the RGC’s Enterprise Research environment as industry-quality software

This role requires:

• Master’s (PhD preferred) in Bioinformatics or equivalent
• 0-3 years of experience in sequencing informatics methodology, including base calling, read mapping, and variant calling algorithms and software.
• Experience with large-scale multi-omics data types, including DNA-seq (short and long read), RNA-seq, proteomics, methylation.
• Expert fluency in state-of-the-art bioinformatic tools and standards.
• Demonstrated engagement in the sequencing bioinformatics community.
• Experience creating or adapting novel bioinformatic data structures and file formats to improve actionability.

Does this sound like you?

We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually) $109,900.00 - $179,300.00

Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for over 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to nine FDA-approved treatments and numerous product candidates in development, almost all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurology, infectious diseases and rare diseases. Regeneron is also proud of award winning culture of innovation, being recognized as a Great Place to Work in 2021, Fast Company’s Best Workplace for Innovators in 2020, and Forbes JUST companies in 2020, among others.