Associate Laboratory Manager

Cabaletta Bio Inc.; Philadelphia (Philadelphia County); Hybrid; USD 70,000 - 95,000; Full time

Job summary

Cabaletta Bio is seeking an Associate Laboratory Manager to support daily operations of the growing lab space in Philadelphia, reporting to the Head of Lab Operations. This role involves inventory management, equipment upkeep, and ensuring adherence to GxP SOPs, with potential for involvement in new lab build-out and external collaborations.

You will gain exposure to cellular, molecular, and biochemical workflows, while developing documentation and safety processes in a dynamic biotech setting.

Qualifications

• Bachelor’s degree in a scientific discipline and 1+ years of experience.
• Aseptic technique and general lab experience (cell culture prep, molecular/biochemical assays).
• Must be able to lift about 40 lb onto a cart and ~10 lb overhead.
• Foundational understanding of laboratory equipment.
• Strong attention to detail and organizational skills.
• Clear written and verbal communication and ability to work independently.
• Proactive attitude and willingness to help.
• Strong team orientation and drive for self-development.

Responsibilities

• Daily upkeep of laboratory space, including restocking supplies and waste disposal.
• Lead daily startup requirements for specialty equipment.
• Assist with equipment monitoring and maintenance across lab spaces.
• Move and change out 230-liter LN2 tanks; must be able to push on wheels.
• Support inventory management and restocking processes; input items into inventory systems.
• Maintain cold storage inventory in core lab spaces.
• Help maintain documentation (IOPQ, PMs, COA/COC, calibrations).
• Assist with purchase orders and quotes; organize equipment cleaning efforts.
• Provide lab access for external personnel (vendors, field service engineers).
• Assist with pipette calibration and input into equipment management system.
• Support implementation of laboratory guidelines and GxP SOPs.

Skills

Aseptic technique

Lab operations

Communication skills

Attention to detail

Independent work

Team orientation

Physical lifting ability

Education

Bachelor’s degree in a scientific discipline

Tools

LIMS or ELN

Job description

Position Title: Associate Laboratory Manager

Location: On Site – Philadelphia, PA — 1 day/week work from home

Reports to: Head of Lab Operations

Department: Research

Cabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases. The lead CARTA (Chimeric Antigen Receptor T cells for Autoimmunity) strategy is prioritizing the development of rese-cel, a 4-1BB-containing fully human CD19-CAR T cell investigational therapy. Rese-cel is currently being evaluated in the RESET clinical development program spanning multiple therapeutic areas, including rheumatology, neurology and dermatology. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, please visit www.cabalettabio.com and connect with us on LinkedIn.

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew.

We’re proud to be a Great Place to Work-Certified company! #GPTWcertified Check out what our employees say makes working here so great: Working at Cabaletta Bio Inc | Great Place to Work

Associate Laboratory Manager

Philadelphia, PA

About the Position

At Cabaletta we are applying our Cabaletta Approach to B cell Ablation (CABA) to develop T cell therapies to transform the lives of patients with autoimmune diseases. Reporting to the Head of Lab Operations, the Associate Laboratory Manager will support the operations, leadership, direction, and administration of our growing laboratory space, including a longer-term opportunity with new lab build out. The role will offer opportunities to work and cultivate skills within the cellular, molecular, and biochemical arenas, as well as inventory management and waste disposal/safety procedures.

Responsibilities

• Daily upkeep of laboratory space, including but not limited to, restocking of supplies, biological waste disposal, and preparation of media, buffers, and solutions.
• Lead daily startup (when applicable) requirements for specialty equipment.
• Assist with equipment monitoring including alarm system and annual maintenance across multiple teams and lab spaces.
• Compressed gas tank movement and change out. Must be capable of pushing 230-Liter LN2 tank on wheels.
• Support inventory management and purchasing activities by maintaining organizational oversight of laboratory supplies and restocking processes.
• Including inputting items into inventory management and weekly checks.
• Maintain cold storage inventory within the core laboratory lab spaces
• Help maintain variety of documentation across lab ops e.g. IOPQs, PMs, COA/COC, calibrations
• Support quote and purchase order organization
• Point person for equipment cleaning efforts throughout all lab spaces e.g. incubators, centrifuges, water/bead baths.
• Assist in equipment cleaning maintenance records, including collection and technical review
• Aids in deviations associated with equipment maintenance records, working closely with quality representatives
• Assist in providing lab access for external personnel e.g. vendors, field service engineers, and building management.
• Assist with biannual pipette calibration including collection, document review and input into Cabaletta’s equipment management system.
• Support implementation of laboratory guidelines and standard operating procedures consistent with GxP requirements.

Qualifications Required

• Bachelor’s degree in a scientific discipline with 1+ years of experience.
• Aseptic technique and general lab experience e.g. cell culture maintenance, preparing laboratory reagents for experimental use, molecular or biochemical assays, protein or bacteria work.
• Must be able to lift ~40lb onto a cart and ~10lb over your head.
• Foundational understanding of laboratory equipment.
• Strong attention to detail and organizational skills are required.
• Clear written and verbal communication skills and an ability to work independently.
• Proactive attitude and helpful mindset.
• Strong team orientation and passion for continuous self-development.

Preferred Qualifications

• Experience with sample/inventory tracking and management.
• Experience with LIMS or ELN
• Foundational knowledge of GDP, GLP
• A high level of flexibility to support various other activities; the ability to learn new techniques outside of existing field of expertise.
• Two plus years of lab operations experience within industrial or academic settings

Our name — Cabaletta — is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.

For more information, please visit https://www.cabalettabio.com/join-our-crew

Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.

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