Associate Engineer II, Polysaccharide Upstream Pilot Plant

Viltis Consulting; San Carlos (CA); On-site; USD 70,000 - 85,000; Full time

Job summary

A leading company in vaccine innovation seeks an Associate Engineer II for their Polysaccharide Upstream Pilot Plant. This role involves hands-on laboratory work, collaborating on experiments for vaccine development, requiring a solid background in engineering or biochemistry and a passion for biotechnology. Candidates should be ready to engage in a dynamic team environment and contribute significantly to the progress of their pioneering vaccine projects.

Qualifications

• 1-3+ years of experience in biopharmaceuticals or vaccine industries.
• Experience with fermentors and bioreactors.
• Familiarity with DoE principles.

Responsibilities

• Operate and maintain fermentation equipment for polysaccharides.
• Support preparations for lab experiments.
• Present experimental data and collaborate with team.

Skills

Team collaboration

Technical communication

Problem-solving

Education

B.S. or M.S. in Biochemical Engineering, Biochemistry, or related discipline

Tools

Microsoft Excel

Microsoft Word

Microsoft PowerPoint

Job description

Associate Engineer II, Polysaccharide Upstream Pilot Plant

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Associate Engineer II, Polysaccharide Upstream Pilot Plant

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Other Area(s)

San Carlos , California Direct Hire Nov 15, 2023

Company Profile

Our client is a vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. The Company is developing broad-spectrum conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases. Their lead candidate is a 24-valent, broad-spectrum, carrier-sparing pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease (IPD). The Company is re-engineering the way highly complex immunizations are made through modern synthetic techniques, including advanced chemistry and our exclusively licensed XpressCFTM cell-free protein synthesis platform. The Company is driven to eradicate or treat invasive bacterial infections, which have serious and costly health consequences when left unchecked.

Summary

Our client is looking for an energetic and talented Associate Engineer II to contribute to the Polysaccharide Upstream Pilot Plant function within the CMC team. They are developing a multi-valent polysaccharide-based conjugate vaccine, based on a novel carrier protein produced using the Xpress CF platform. Polysaccharides are a critical component in conjugate vaccines.

The successful candidate will have practical laboratory fermentation experience in executing, supporting, or developing upstream processes related to biotechnology, biopharmaceuticals, or vaccine industries. The candidate will be eager to utilize and learn new laboratory skills as this person will be responsible for collaboration on experimental design and execution of experiments at pilot scale for scale down modelling efforts and manufacturing program development. This position will require >80% time in the lab and this person will be able to collaborate on experimental procedures/results in written and presentation format. The successful candidate will write detailed technical reports, present experimental results internally, and potentially interface with external CMO partners.

Essential Functions

• Operate and maintain equipment and instrumentation for polysaccharide fermentation such as fermenters, depth filtration, and metabolite analyzers.
• Support media and buffer preparations for the experiments.
• Perform analysis and interpret results for polysaccharide and impurity assays for both internal Process Development and Manufacturing samples.
• Assist in design and execution of upstream process development studies, including protocols and reports.
• Keep accurate and current records of development experiments and/or project related activities in laboratory notebooks or electronic laboratory notebooks.
• Assist in compiling process development and manufacturing data for statistical analysis for scale down modeling and process characterization purposes.
• Present data from experiments to the team and contribute to technical discussions.
• Work within a team environment and provides support as necessary to further the team’s initiatives.
  
  

Requirements:

• B.S. or M.S. in Biochemical Engineering, Biochemistry, or a related discipline.
• 1-3+ years of experience.
• Experience with the operation, preparation, and handling of fermentors (preferred) or bioreactors. Experience with centrifugation and TFF systems for primary recovery a plus.
• Experience with method analysis of fermentation in-process and final results such as UV-spectrophotometry, metabolite analyzers, and plate-based assays.
• Experience in writing experimental protocols and summary reports.
• Familiarity with DoE (Design of Experiments) principles and practical experience with DoE software a plus.
• Proficient with computer programs such as Microsoft Excel, Word, PowerPoint.
• Working knowledge of the requirements of GxPs (GMP a plus).
• Demonstrated strong ability to work in a cross-functional team environment on multiple projects.
• Strong interpersonal skills, with excellent written and verbal communication skills.
• All employees require vaccination against COVID-19.
  
  

Reports to: Associate Director, Polysaccharide Pilot Plant and Manufacturing

This job will be reviewed periodically and is subject to change by management.

Seniority level

• Seniority level

  Entry level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Engineering and Information Technology

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