Associate Director, Tumor Functional Genomics and Perturbation Analytics

Takeda; Cambridge (MA); Hybrid; USD 154.000 - 243.000; Vollzeit

Zusammenfassung

Takeda in Cambridge, MA, is hiring Associate Director, Tumor Functional Genomics and Perturbation Analytics to lead delivery of tumor functional-genomics capabilities within Oncology Computational Biology Delivery. You will partner with oncology scientists and AI/ML teams to shape analytical strategies and scalable data products.

The role emphasizes CRISPR screening, single-cell genomics, Perturb-seq, and integration of multi-omics data to drive target identification, biomarker discovery, and

Qualifikationen

• PhD or equivalent with 7+ years post-degree experience in computational biology/oncology.
• Deep expertise in tumor functional genomics and perturbation biology (CRISPR, Perturb-seq).
• Experience applying computational methods to oncology data and drug discovery.

Aufgaben

• Lead delivery of tumor functional-genomics and perturbation-analytics analyses and reusable data products.
• Provide scientific leadership in tumor biology, functional genomics, perturbation biology, and computational oncology.
• Develop analytical approaches for CRISPR screens and single-cell genomics.
• Integrate diverse omics datasets to support target identification and biomarker discovery.
• Collaborate with biology, translational, AI/ML, and software teams to deliver scalable research capabilities.
• Establish standards for validation, data quality, provenance, and reproducibility.

Kenntnisse

Tumor functional genomics

Perturbation biology

CRISPR screens

Single-cell genomics

Perturb-seq

Data integration

AI-enabled workflows

Leadership

Scientific communication

Computational biology

Ausbildung

PhD in Computational Biology or related field

Tools

Python

R

SLURM

Jobbeschreibung

Job Description:

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as an Associate Director, Tumor Functional Genomics and Perturbation Analytics :in our Cambridge office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future: to people around the world.

Objective / Purpose:

The Associate Director, Tumor Functional Genomics and Perturbation Analytics will be a key scientific and delivery leader within the Oncology Computational Biology Delivery team in the Computational Biology and Human Genetics organization. Reporting to the Director, Head of Oncology Computational Biology Delivery, this role will lead the development and application of tumor functional-genomics and perturbation analytics capabilities to advance the Oncology Research pipeline.

The role will provide deep expertise in computational biology, tumor functional genomics, perturbation biology, CRISPR screening, single-cell genomics, Perturb-seq, and related systems. The Associate Director will develop analyses, data resources, evidence packages, and reusable computational products that generate novel biological insight and support target identification and validation, biomarker discovery, patient stratification, and therapeutic development.

The successful candidate will combine recognized scientific expertise with strong delivery leadership, rigorous analytical judgment, and a product-oriented approach. The individual will collaborate with oncology research scientists, target validation teams, AI/ML scientists, data scientists, software engineers, and data engineers to define priorities and deliver scalable, reproducible computational capabilities. The role will also advance AI-enabled ways of working and frontier approaches for extracting biological insights from cancer-omics and perturbation data.

Accountabilities:

• Lead the delivery of tumor functional-genomics and perturbation-analytics analyses, data resources, evidence packages, and reusable computational products supporting Oncology Research and portfolio decisions.
• Provide scientific leadership in tumor biology, functional genomics, perturbation biology, cancer genomics, and computational oncology.
• Develop and apply robust analytical approaches for CRISPR screens, pooled and arrayed perturbation experiments, single-cell genomics, Perturb-seq, and related functional-genomics systems.
• Integrate perturbation, tumor-omics, single-cell, genetic, phenotypic, and translational datasets to generate insights supporting target identification and validation, mechanism-of-action hypotheses, biomarker identification, patient stratification, and therapeutic development.
• Partner with biology, target validation, translational, pharmacology, and drug discovery teams to define scientific questions, design analytical strategies, and ensure that computational findings are interpretable, actionable, and aligned with program needs.
• Establish appropriate standards for scientific validation, data quality, reproducibility, version control, testing, documentation, provenance, usability, maintenance, and ownership for perturbation-analytics workflows and data products.
• Develop reusable computational methods, workflows, and analysis frameworks that improve the consistency, speed, accessibility, and scientific quality of functional-genomics support across the Oncology portfolio.
• Define and implement AI-enabled approaches for design and analysis of functional genomics and perturbation biology experiments, including methods for data discovery, experimental evidence synthesis, analysis planning, workflow execution, quality control, interpretation, and generation of scientific deliverables.
• Evaluate and apply frontier AI biological foundation models and related approaches leveraging cancer-omics and perturbation data to generate novel insights for oncology target identification, therapeutic development, and patient selection.
• Collaborate with AI/ML, data science, software engineering, and data engineering teams to develop analytical prototypes and AI concepts into reliable, scalable, sustainable research capabilities.
• Balance program-specific analytical support with investment in reusable functional-genomics capabilities and shared products.
• Manage delivery priorities, risks, dependencies, and tradeoffs across multiple stakeholders; clearly communicate progress, scientific findings, limitations, and emerging opportunities to the Director and cross-functional teams.

Education & Competencies:

• PhD in Computational Biology, Bioinformatics, Cancer Biology, Functional Genomics, Human Genetics, Genomics, Data Science, or a related discipline, with 7 or more years of relevant post-degree experience and a demonstrated record of scientific impact; or equivalent combination of education and experience.
• Deep expertise in tumor functional genomics and perturbation biology, including CRISPR screens, single-cell genomics, Perturb-seq, and related experimental and analytical systems.
• Strong knowledge of cancer biology, tumor genomics, statistical genomics, multimodal data integration, bioinformatics, and quantitative analysis of complex biological datasets.
• Demonstrated experience applying computational methods to functional-genomics and perturbation datasets in support of oncology drug discovery, target validation, biomarker discovery, or therapeutic development.
• Experience developing reproducible, scalable analysis workflows, data resources, or computational products for scientific users.
• Experience applying AI-accelerated ways of working in computational biology and evaluating the application of frontier AI methods or biological foundation models to cancer-omics and perturbation data.
• Ability to translate complex functional-genomics results into clear biological hypotheses, evidence packages, and actionable recommendations for research and portfolio teams.
• Understanding of modern software, data-product, and AI-product practices, including version control, testing, documentation, provenance, reproducible computing, deployment, monitoring, and lifecycle management.
• Demonstrated ability to lead delivery across multiple programs and stakeholders, set priorities, manage risks, and communicate tradeoffs in a complex matrix environment.

Here, you will be a vital contributor to our inspiring, bold mission.

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law

This position is currently classified as “hybrid” in accordance with Takeda’s Hybrid and Remote Work policy.

Takeda Compensation and Benefits Summary:

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

USA - MA - Cambridge - Kendall Square - 500

U.S. Base Salary Range :

$154,400.00 - $242,550.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

Benefits

For information about our benefits, please click here.

EEO Statement:

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations:

USA - MA - Cambridge - Kendall Square - 500

Worker Type:

Employee

Worker Sub-Type:

Regular

Time Type:

Full time

Job Exempt:

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.