Associate Director, Translational Science

Legendcareers; New Jersey; On-site; USD 168,372 - 220,988; Full time

Benefits offered by this job

Medical, dental, and vision insurance

401(k) retirement plan with company match

Paid parental leave

Extensive paid time off

Job summary

Legendcareers is looking for an Associate Director of Translational Science based in Somerset, NJ. This role involves bridging early-stage discovery research and clinical development, requiring expertise in immunology and computational biology.

The successful candidate will lead translational strategies, analyze high-dimensional datasets, and manage collaborations with external partners. A PhD or MD/PhD and 5+ years of relevant experience in biopharmaceuticals are required.

Qualifications

• 5+ years of experience in biopharmaceutical industry or academic leadership role.
• Experience with data integration and regulatory requirements for clinical trials.
• Understanding of biological mechanisms related to auto-immune and oncology diseases.

Responsibilities

• Lead development of translational plans through Phase II clinical trials.
• Oversee analysis of high-dimensional datasets for pharmacodynamic markers.
• Manage relationships with CROs for assay development.

Skills

Immunological expertise

Computational proficiency

Genomic data analysis

Project management

Education

PhD or MD/PhD in Immunology or related field

Tools

Data analysis pipelines

Job description

Associate Director, Translational Science

Based in Somerset, NJ.

Role Overview

The Associate Director of Translational Science will bridge the gap between early‑stage discovery research and clinical development. This role requires a unique blend of deep immunological expertise and advanced computational proficiency. You will be responsible for designing and executing translational strategies, identifying biomarkers, and leveraging large‑scale multi‑omic datasets to provide actionable insights into mechanism of action (MoA), patient stratification, and drug resistance in both autoimmune and oncology disease areas.

Key Responsibilities

• Translational Strategy: Lead the development and execution of program‑specific translational plans from lead optimization through Phase II clinical trials.
• Data Integration & Analysis: Oversee the analysis of high‑dimensional datasets (e.g., scRNA‑seq, CITE‑seq, flow cytometry, and spatial transcriptomics) to identify pharmacodynamic markers and predictive signatures, and provide insight into biological mechanisms.
• Clinical Collaboration: Partner with Clinical Development and Clinical Operations to implement biomarker assays in clinical protocols and ensure high‑quality data collection.
• External Partnerships: Manage relationships with Contract Research Organizations (CROs) and academic collaborators for specialized assay development and advanced data processing.
• Cross‑Functional Leadership: Represent Translational Science on program teams, providing expert input on disease biology, target engagement, and competitive landscape.
• Scientific Communication: Author high‑quality technical reports, regulatory documents (IND/IB/NDA), and contribute to peer‑reviewed publications and conference presentations.

Requirements

• PhD or MD/PhD in Immunology, Bioinformatics, Computational Biology, or a related field.
• 5+ years of experience in the biopharmaceutical industry or an equivalent academic leadership role within translational research.
• Extensive knowledge of human autoimmune disease and oncology diseases, specifically in areas such as immuno‑oncology, autoimmune diseases, or cell therapy (CAR‑T/TCR‑T).
• Demonstrated experience with genomic data analysis. Practical and hands‑on experience with data analysis pipelines, guidance on data integration, and knowledge integration from multiple datasets.
• Proven track record in the development, validation, and clinical implementation of complex biomarkers.
• Experience working with relevant disease areas, with a deep understanding of the biological mechanisms related to diseases (auto‑immune, oncology, or both).
• Strong understanding of regulatory requirements for biomarker‑driven clinical trials.
• Excellent project management skills with the ability to lead multiple programs in a fast‑paced environment.
• High scientific curiosity, driven, and motivated in deep understanding of the biology behind both disease and therapies.

Benefits and Compensation

Base Pay Range: $168,372 – $220,988 USD.

Other Types of Pay: Performance‑based bonus and/or equity is available to employees in eligible roles.

Benefits and Paid Time Off: Medical, dental, and vision insurance; a 401(k) retirement plan with a company match that vests fully on day one; eight weeks of paid parental leave after three months; paid time off including vacation, personal, sick, floating holidays, and eleven company holidays; voluntary benefits such as flexible spending & health savings accounts, life and AD&D insurance, short‑ and long‑term disability coverage, legal assistance, supplemental plans, commuter benefits, family planning and care resources, well‑being initiatives, and peer‑to‑peer recognition programs.

Note: These benefits are offered exclusively to permanent full‑time employees. Contractors are not eligible for benefits through Legend Biotech.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.