Associate Director, Translational Modeling & Simulation

Novartis; Cambridge (MA); Hybrid; USD 153,000 - 283,000; Full time

Benefits offered by this job

Performance-based incentive

Annual equity awards eligibility

Comprehensive benefits (health, life,

disability)

401(k) with company match

Generous time off

Job summary

Novartis in Cambridge, MA is seeking a translational modeler (Associate Director) to lead model-informed decisions across discovery and early clinical development. Build PK/PD, QSP, PBPK/PD models to connect biology to dose strategies, collaborating with discovery, preclinical, and clinical teams in a hybrid environment.

The role reports to an M&S team lead within PKS M&S. Compensation includes a salary range of $152,600–$283,400 plus incentive opportunities and eligibility for equity

Qualifications

• Ph.D. in biology, bioengineering, pharmaceutical sciences, biophysics, or a related field with 7+ years of industry experience.
• Expert in modeling fundamentals including scripting (MATLAB, R), ODEs, parameter estimation, and data visualization.
• Expert in PK/PD, QSP, and PBPK/PD; familiarity with population PK is preferred.
• Experience integrating computational modeling with biology and disease areas (neuroscience, cardiovascular, metabolism) is valued.

Responsibilities

• Act as the M&S representative on programs; develop and execute modeling strategies to inform dose selection and beyond.
• Build and apply mechanistic PK/PD, QSP, and PBPK/PD models linking pharmacology to tissue distribution and mechanism of action.
• Integrate modeling into design/interpretation of preclinical studies to support candidate selection and progression.
• Develop platform translational modeling strategies and expand modeling workflows across programs.
• Mentor and collaborate across M&S platforms and initiatives within Novartis.

Skills

MATLAB

R

ODE modeling

PK/PD

QSP

PBPK/PD

Population PK

English communication

Education

Ph.D. in biology / bioengineering / pharmaceutical sciences / biophysics

Tools

NONMEM

MATLAB

R

SimBiology

Job description

Novartis in Cambridge, MA is seeking a translational modeler (Associate Director) to lead model-informed decisions across discovery and early clinical development. Build PK/PD, QSP, PBPK/PD models to connect biology to dose strategies, collaborating with discovery, preclinical, and clinical teams in a hybrid environment.

The role reports to an M&S team lead within PKS M&S. Compensation includes a salary range of $152,600–$283,400 plus incentive opportunities and eligibility for equity