Associate Director, Quantitative Pharmacology

Regeneron; United States; On-site; USD 180,000 - 240,000; Full time

Job summary

Regeneron is seeking an Associate Director in Quantitative Pharmacology to lead model‑informed development strategies across modalities, guiding dose selection, trial design, and regulatory submissions from early development through approval.

The role requires a PhD or equivalent experience, cross‑functional leadership, and expertise in PK/PD, exposure‑response, and QSP using NONMEM, Monolix, Simulx, MATLAB/Simbiology, and R; mentoring and advancing quantitative tools are key expectations.

Qualifications

• PhD or equivalent with extensive pharmacometrics experience.
• Experience delivering analyses for regulatory submissions.
• Strong publication record and cross‑functional collaboration.

Responsibilities

• Drive model‑informed development and PK/PD strategies across modalities.
• Lead population PK/PD, exposure‑response and translational analyses.
• Represent QP in governance meetings and communicate insights clearly.
• Contribute to regulatory documents and interactions with agencies.
• Mentor junior scientists and foster scientific rigor.
• Identify and implement innovative quantitative tools and processes.
• Ensure analyses meet quality and regulatory standards.

Skills

Population PK/PD

Exposure‑response

Mechanistic modeling

NONMEM

Monolix

Simulx

MATLAB/Simbiology

R

Education

PhD in Quantitative Pharmacology/Pharmacometrics/Engineering or related field

MS with 9+ years of relevant experience

Tools

NONMEM

Monolix

Simulx

MATLAB/Simbiology

R

Job description

Build our future together:

We are seeking a highly motivated Associate Director (AD) to join the Quantitative Pharmacology (QP) group. The AD will lead model-informed drug development strategies supporting one or more therapeutic areas across modalities including antibodies, siRNA, and gene therapies. This role combines scientific depth with cross-functional leadership to inform dose selection, trial design, and regulatory strategy from early development through submission.

When & where:

Location: Tarrytown, NY, Cambridge, MA, Warren, NJ, Remote, USA

Work model/flexibility: 4 days onsite

Discover your role:

• Driving model‑informed development (MIDD) and pharmacometrics strategies in partnership with Clinical Pharmacology, Biostatistics, Clinical and Translational teams to support regulatory and clinical decision‑making.
• Leading the QP evaluation of one or more assets, accountable for timely delivery of population PK/PD, exposure‑response, and translational modeling analyses.
• Representing QP at program and governance meetings, communicating quantitative insights clearly to non‑modeling audiences.
• Contributing to regulatory interactions and authoring key components of regulatory documents related to QP (e.g., IB, briefing books, etc.).
• Mentoring and developing junior scientists and fostering a culture of scientific rigor and collaboration.
• Identifying and implementing process improvements, new modeling approaches, and innovative quantitative tools to enhance efficiency and impact.
• Ensuring analyses and documentation are of the highest scientific quality and regulatory compliance.

This role requires:

• PhD in Quantitative Pharmacology, Pharmacometrics, Engineering, or a related field
• 6+ years of post‑doctoral or industry experience; or MS with 9+ years of relevant experience.
• Demonstrated expertise in population PK/PD, exposure‑response, or mechanistic modeling (systems biology, or QSP) using tools such as NONMEM, Monolix, Simulx, MATLAB/Simbiology and R.
• Proven track record of delivering analyses supporting regulatory submissions and engaging directly with agencies (e.g., FDA, EMA, PMDA).
• Hands‑on experience with a broad range of quantitative and computational tools and a strong publication record.
• Exceptional communication and interpersonal skills, with the ability to influence and partner effectively across technical and non‑technical teams.

Does this sound like you?

We are committed to building a workplace with an inclusive culture.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role:

• annual bonuses or other incentive plans
• equity awards
• pension or retirement benefits
• 401(k) company match
• health and wellness programs
• fitness centers
• insurance benefits (e.g. medical, dental, vision, life and disability)
• paid time off
• family support benefits

For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualificati