Associate Director, Pricing and Access Analytics

Amylyx Pharmaceuticals, Inc.; United States; On-site; USD 182,000 - 205,000; Full time

Job summary

Amylyx Pharmaceuticals is seeking an Associate Director, Pricing Strategy & Access Analytics to lead pricing analytics, gross-to-net modeling, and payer insights within Market Access. This hands-on role partners with cross-functional teams to inform avexitide pricing and access decisions for PBH and related programs.

The role requires 6+ years in market access or related pharma analytics, advanced Excel skills, and the ability to travel occasionally.

Qualifications

• Bachelor’s degree required; advanced degree preferred.
• 6+ years of experience in market access, pricing, contracting, analytics, finance, forecasting, patient services, or related pharmaceutical/biotech roles.
• Strong understanding of U.S. pricing, gross-to-net, payer, PBM, health system, reimbursement, and patient access dynamics.
• Demonstrated ability to build analytical models, interpret complex data, and communicate practical recommendations to cross-functional and senior stakeholders.
• Experience in rare disease, specialty pharmacy, launch planning, pricing strategy, contracting analytics, or patient services analytics preferred.
• Advanced Microsoft Excel, PowerPoint, pivot table, financial modeling, PBM/payer negotiations & scenario analysis skills
• High business and P&L acumen, GTN accounting dynamics across access customer types (commercial, government, patient services, specialty pharmacy)
• High integrity, collaboration, and ability to work in a fast-paced, cross-functional environment.
• Ability and willingness to travel occasionally

Responsibilities

• Lead pricing analysis, scenario planning, gross-to-net modeling, rebate and contracting economics.
• Build and maintain financial models evaluating pricing options, payer and PBM contracting opportunities, and business-case assumptions.
• Co-lead pricing committee with Market Access, Finance, Forecasting, Legal, Compliance, Commercial, and Analytics teams.
• Monitor and analyze policy and pricing trends that may impact launch of avexitide.
• Partner with finance to assess risk and develop mitigation for government pricing calculations and reporting.
• Ensure compliance and State Drug Pricing Transparency reporting.
• Analyze payer coverage, utilization management, formulary positioning, and reimbursement dynamics.
• Develop dashboards, scorecards, and insights synthesizing payer, PBM, health system, and channel trends into actionable recommendations.
• Monitor external market trends, Medicare/Medicaid considerations, and channel evolution affecting pricing, access, and reimbursement strategy.
• Support vendor selection and management for market access data, pricing analytics, and research projects.

Skills

Pricing analytics

Financial modeling

Payer negotiations

GTN accounting

Microsoft Excel

PowerPoint

Pivot tables

Scenario analysis

Cross-functional collaboration

Education

Bachelor’s degree

MBA/MPH/MS/PharmD or related

Tools

Microsoft Excel

PowerPoint

Job description

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.

The Opportunity

Amylyx is seeking an Associate Director, Pricing Strategy & Access Analytics to serve as a hands-on strategic partner within Market Access. Reporting to the Senior Director, Market Access Strategy, this individual will be responsible for helping lead pricing strategy, analytics, gross-to-net modeling, contracting evaluation, and related decision support. The role will also support broader market access priorities, including identifying actionable payer and PBM insights, monitoring coverage and channel strategy trends, and generating patient access analytics to inform decision-making. The role will translate complex access, pricing, and customer data into clear, actionable recommendations that support access to avexitide (subject to FDA approval) for patients with post-bariatric hypoglycemia (PBH), an area of significant unmet need.

Responsibilities

Pricing strategy and analytics:

• Lead pricing analysis, scenario planning, gross-to-net modeling, rebate and contracting economics, competitive pricing assessments to inform avexitide launch price and lifecycle decisions.
• Build and maintain financial models that evaluate pricing options, payer and PBM contracting opportunities, customer trade-offs, access implications, and business-case assumptions.
• Partner with Sr. Director, Access Strategy and co-lead pricing committee with Market Access, Finance, Forecasting, Legal, Compliance, Commercial, and Analytics teams to align pricing assumptions, pressure-test recommendations, and support compliant decision-making. Helps maintain and operationalize pricing committee.
• Monitor and analyze policy and pricing trends with potential to impact launch of avexitide
• Partner with finance to help assess risk and develop mitigation solution for potential government pricing calculations and reporting
• Ensure compliance and State Drug Pricing Transparency reporting.

Broader access analytics:

• Analyze payer coverage, utilization management, formulary positioning, reimbursement dynamics, claims trends, abandonment, reversals, pull-through performance, and patient access barriers.
• In collaboration with commercial operations and market access stakeholder, develop dashboards, scorecards, customer insights, and executive-ready materials that synthesize payer, PBM, health system, specialty pharmacy, channel, and patient services trends into actionable recommendations.
• Monitor external market trends, policy changes, competitive dynamics, Medicare/Medicaid reimbursement considerations, and channel evolution that may affect pricing, access, and reimbursement strategy.
• Support vendor selection and management for market access data, pricing analytics, and research projects, ensuring high-quality outputs and timely delivery.

Required Qualifications

• Bachelor’s degree required; advanced degree such as MBA, MPH, MS, PharmD, or related discipline preferred.
• 6+ years of experience in market access, pricing, contracting, analytics, finance, forecasting, patient services, or related pharmaceutical/biotech roles;
• Strong understanding of U.S. pricing, gross-to-net, payer, PBM, health system, specialty pharmacy, reimbursement, and patient access dynamics.
• Demonstrated ability to build analytical models, interpret complex data, and communicate practical recommendations to cross-functional and senior stakeholders.
• Experience in rare disease, specialty pharmacy, launch planning, pricing strategy, contracting analytics, or patient services analytics preferred.
• Advanced Microsoft Excel, PowerPoint, pivot table, financial modeling, PBM/payer negotiations & scenario analysis skills
• High business and P&L acumen, with a strong foundation of GTN accounting dynamics across access customer types (commercial, government, patient services, specialty pharmacy, trade & distribution)
• High integrity, strong collaboration skills, and comfort operating in a fast-paced, cross-functional environment.
• Ability and willingness to travel occasionally

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
• You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

Compensation

The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.

Estimated Pay Range

$182,000—$205,000 USD

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Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.

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