Associate Director, Clinical Science — Cardiovascular Translational

braveheartbio; United States; On-site; USD 180,000 - 250,000; Full time

Job summary

Braveheart Bio is seeking an Associate Director, Clinical Science to drive translational and clinical science strategy for BHB-1893 across oHCM and nHCM. You will partner with Clinical Development Medical Directors to shape study design, endpoints, and regulatory strategy.

You will lead independent data reviews, collaborate with Biometrics, Clinical Pharmacology, Data Management, and Clinical Operations, and contribute to regulatory submissions while representing Braveheart's science to

Qualifications

• PhD or equivalent research doctorate (field flexible); other advanced degrees (e.g., PharmD, MS with substantial relevant experience) will be considered
• 6+ years of experience in clinical development and/or translational research
• Demonstrated experience conducting hands-on review and quality control of clinical data listings
• Experience collaborating with co-development partners, CROs, or other external organizations on clinical data review, cleaning, and reconciliation, ideally in global Phase 3 trials through database lock
• Strong independent data analysis skills, including the ability to identify patterns, anomalies, and scientific signals in complex clinical datasets
• Working knowledge of cardiovascular disease biology, ideally including sarcomere biology and hypertrophic cardiomyopathy
• Experience authoring or contributing to clinical study protocols, clinical study reports, and regulatory documents (e.g. NDA/MAA submissions)
• Strong interpersonal and communication skills for bridging between scientific and business participants, for negotiating timelines and for effective international collaboration

Responsibilities

• Partner with the Clinical Development leads to shape translational and clinical science strategy for BHB-1893 across oHCM and nHCM, in partnership with Medical Directors and cross-functional program leadership
• Drive scientific input into protocol design and endpoint selection, drawing on sarcomere biology and disease-specific pharmacodynamic considerations
• Lead clinical and scientific review of clinical data listings, identifying and resolving data anomalies in partnership with Biometrics
• Serve as a key clinical science point of contact with Braveheart's global co-development partner, supporting clinical data review, cleaning, and reconciliation activities, and resolving data discrepancies across global Phase 3 programs
• Independently analyze clinical, biomarker, and exploratory endpoint data to generate scientific insights that inform program strategy
• Develop exploratory analyses with Biometrics and Clinical Pharmacology to interrogate complex datasets
• Author and review clinical study reports, investigator brochures, abstracts/publications, and scientific components of regulatory submissions, including NDA/MAA
• Represent the science of BHB-1893 with key opinion leaders, at scientific conferences, and in advisory board settings

Education

PhD or equivalent research doctorate

MS with substantial relevant experience

PharmD

Job description

Braveheart Bio is seeking an Associate Director, Clinical Science to drive translational and clinical science strategy for BHB-1893 across oHCM and nHCM. You will partner with Clinical Development Medical Directors to shape study design, endpoints, and regulatory strategy.

You will lead independent data reviews, collaborate with Biometrics, Clinical Pharmacology, Data Management, and Clinical Operations, and contribute to regulatory submissions while representing Braveheart's science to