Associate Director, Biostatistics

OSI; Boston, Northern (MA, KY); Hybrid; USD 205,000 - 236,000; Full time

Benefits offered by this job

Annual bonus

Equity

Health insurance

Life and disability insurance

Paid time off

Parental leave

401(k)

Cell phone reimbursement

Student loan repayment

529 contributions

Lifestyle spending account

Job summary

PepGen is hiring an Associate Director, Biostatistics in Boston to lead statistical support for clinical programs and collaborate with senior leadership. You will contribute to protocol development, study design, analyses, regulatory submissions, and vendor management.

Strong SAS/R skills and CRO oversight are required. Responsibilities include preparing SAps, TLF reviews, and ensuring timely deliverables across study teams.

Qualifications

• MS required (Ph.D. preferred) in Biostatistics, Statistics, or related fields with 8+ years of experience in drug development.
• Experience in neuromuscular or rare diseases preferred.
• Knowledge of statistical topics across drug development including efficacy, safety, and PRO endpoints.
• Regulatory (s)NDA/BLA/MAA submissions experience preferred.
• Must have hands-on SAS and R programming in clinical trials.
• Experience supporting or managing CROs and contractors.

Responsibilities

• Support the development of statistical sections of clinical study protocols, SAPs, and contribute to analysis and reporting of clinical trial data, including TLFs, SDTM and ADaM specifications, CSR, and regulatory submissions.
• Provide input to optimize trial designs for pivotal registrational studies; maintain strong competencies in statistical methodology and trial designs, particularly in neuromuscular/rare diseases with familiarity with ICH, FDA, EMA.
• Collaborate with internal and external cross-functional teams to ensure timely statistics deliverables; support oversight of CRO statistical activities and assist in managing contractors and vendors.
• Contribute to the development of Biostatistics SOPs and standards.
• Effectively communicate statistical concepts in written and verbal context to a broad audience.

Skills

SAS

R programming

Biostatistics

Protocol design

CRO management

Education

MS in Biostatistics

PhD preferred

Tools

SAS

R

Job description

The Associate Director, Biostatistics will work in collaboration with the Head of Biometrics and senior leadership to provide strong statistical support to advance PepGen’s clinical program. The Associate Director will serve as a statistical subject-matter expert on our cross-functional team, contributing to protocol development, study design, statistical analysis, regulatory submissions, publications and presentations, as well as supporting the management of CRO and external vendors.

Responsibilities

• Support the development of statistical sections of clinical study protocols, statistical analysis plans (SAP), and contribute to the analysis and reporting of clinical trial data, including review of Tables, Listings, Figures (TLFs), SDTM and ADaM specifications, clinical study reports (CSR), and regulatory submission documents
• Provide input to help optimize trial designs for pivotal registrational studies; maintain strong competencies in statistical methodology and trial designs, particularly in therapeutic areas such as neuromuscular diseases or other rare diseases, with familiarity with ICH, FDA, and EMA guidelines
• Collaborate with internal and external cross-functional teams to ensure timely statistics deliverables; support oversight of CRO statistical activities and assist in managing contractors and vendors
• Contribute to the development of Biostatistics SOPs and standards
• Effectively communicate statistical concepts in written and verbal context to a broad audience

Qualifications

• Minimum of MS required (Ph.D. preferred) in Biostatistics, Statistics, or other related fields with 8+ years of overall experience in drug development in the pharmaceutical industry
• Experience in therapeutic areas such as neuromuscular diseases or other rare diseases preferred
• Knowledgeable about a range of statistical topics across different phases of drug development, including efficacy, safety, and PRO endpoints
• Regulatory (s)NDA/BLA/MAA submission experience preferred
• Must have hands-on experience with SAS and R programming in clinical trials
• Experience supporting or managing CROs and contractors

Compensation

The estimate full-time salary range for this role is between $205,000 to $236,000. The final compensation package offered to a successful candidate will reflect a number of factors including but not limited to prior experience, relevant skills, education, qualifications and certifications, business needs, internal equity, and market data.

PepGen provides eligible employees a comprehensive and competitive total compensation package including but not limited to a discretionary annual bonus, equity, health insurance (including medical, dental, and vision), life and disability insurance, paid time off with paid holidays, paid parental leave, a 401(k) plan, cell phone reimbursement, student loan repayment or 529 contributions, and a lifestyle spending account.

About PepGen

PepGen is a clinical-stage biotechnology company advancing the next generation of oligonucleotide therapies with the goal of transforming the treatment of severe neuromuscular and neurological diseases. PepGen’s Enhanced Delivery Oligonucleotide (EDO) platform is founded on over a decade of research and development and leverages cell-penetrating peptides to improve the uptake and activity of conjugated oligonucleotide therapeutics. Using these EDO peptides, we are generating a pipeline of oligonucleotide therapeutic candidates designed to target the root cause of serious diseases.

For more information, please visit PepGen.com. Follow PepGen on LinkedIn and X.

EEO Statement

PepGen is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status.

Recruitment & Staffing Agencies

PepGen does not accept unsolicited agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited. Thank you.

E-Verify

PepGen is an E-Verify Employer. For more information about E-Verify, please see here .