Architect - Enterprise AI (Memphis, TN / Coppell TX) or Remote in USA

St. Jude Children's Research Hospital - ALSAC; Coppell (TX); Hybrid; USD 180,000 - 240,000; Full time

Benefits offered by this job

Core Medical Coverage

401K Retirement Plan with 7% Employer

Exceptional Paid Time Off

Maternity / Paternity Leave

Infertility Treatment Program

Adoption Assistance

Education Assistance

Enterprise Learning and Development

Job summary

St. Jude Children’s Research Hospital - ALSAC is seeking an Enterprise AI Architect to define and evolve enterprise AI architecture standards, patterns, and governance.

You will partner with Architecture, Engineering, Data, Security, and business teams to ensure scalable, secure, and maintainable AI solutions aligned with ALSAC’s technology strategy. The role requires 10+ years in architecture, strong AI/ML experience, and leadership.

Qualifications

• Bachelor's degree in Computer Science, Information Systems, Engineering, or related field.
• 10+ years in enterprise/solution architecture or related tech disciplines.
• Experience designing and implementing AI, Generative AI, ML, or intelligent automation solutions.
• Experience developing architecture standards, reference architectures, and governance practices.
• Strong understanding of cloud platforms, integration, security, and modern software patterns.
• Ability to communicate technical concepts to technical and non-technical stakeholders.
• 5+ years of leadership, team lead, or architecture influence experience.

Responsibilities

• Define enterprise architecture standards and reference architectures for AI and AI-enabled solutions.
• Collaborate with Enterprise Architecture, Engineering, Data, Security, and business teams to evaluate AI use cases and guide architectural tradeoffs.
• Design reusable architecture patterns for AI gateways, MCP integrations, agent orchestration, and AI platform services.
• Provide architectural guidance for AI security, identity, authorization, governance, and compliance.
• Support AI-DLC adoption through architecture reviews, standards, and reference implementations.
• Define approaches for AI evaluation, observability, monitoring, and cost management.
• Develop reference implementations and proofs-of-concept to accelerate production-grade AI deployments.
• Ensure AI and technology solutions align with enterprise standards and roadmaps.
• Gather and validate requirements impacting ALSAC's enterprise technology environment.

Skills

Bachelor's degree

10+ years experience

AI/ML experience

Architecture standards

Cloud platforms

Leadership

Education

Bachelor's degree

Tools

OpenShift/Kubernetes

Bedrock/MCP

Job description

At ALSAC you do more than make a living; you make a difference.

We like people who are different…because we’re different, too. As one of the world’s most iconic and respected nonprofits, we know what it’s like to stand out. That’s why we’re looking at you. Your background, perspective, and desire to make an impact set you apart. As we work to help St. Jude cure childhood cancer, we're calling on the game-changers, innovators and visionaries to join our family. Not just for the kids of St. Jude, but also for you. Because at ALSAC, we develop and celebrate our employees. So, bring your whole, authentic self and become part of our shared mission: Finding cures. Saving children.®

Job Description

The Enterprise AI Architect is responsible for defining and evolving ALSAC's enterprise architecture standards for Artificial Intelligence (AI), Agentic AI, and AI-enabled applications. This role partners with technology and business teams to ensure AI solutions align with enterprise architecture principles and are scalable, secure, reliable, and maintainable.

The Enterprise AI Architect provides architecture guidance, develops reusable patterns and standards, and helps teams successfully move AI solutions from concept through production implementation. This role collaborates across stakeholders to evaluate technologies, establish best practices, and ensure AI investments support ALSAC's long-term technology strategy.

Essential Job Functions

• Define enterprise architecture standards, reference architectures, and implementation patterns for AI, Agentic AI, and AI-enabled solutions.
• Partner with Enterprise Architecture, Engineering, Data, Security, and business teams to evaluate AI use cases, establish success criteria, and provide guidance on architectural tradeoffs, including model selection, agent design patterns, cost considerations, and responsible AI practices.
• Design and maintain reusable architecture patterns for AI gateways, Model Context Protocol (MCP) integrations, agent orchestration, enterprise knowledge access, retrieval architectures, and AI platform services.
• Establish architectural guidance for AI security, identity management, authorization, governance, compliance, and policy enforcement.
• Support adoption of AI development lifecycle (AI-DLC) practices through architecture reviews, standards, reference implementations, and implementation guidance.
• Define architectural approaches for AI evaluation, observability, monitoring, operational readiness, and cost management.
• Develop reference implementations and proof-of-concept solutions that accelerate delivery and help teams scale AI capabilities into production environments.
• Ensure AI and technology solutions align with enterprise architecture standards, strategic technology roadmaps, and long-term operational objectives.
• Collaborate with stakeholders to gather, analyze, communicate, and validate requirements impacting ALSAC's enterprise technology environment.

Required Qualifications

• Bachelor's degree in Computer Science, Information Systems, Engineering, or a related field.
• 10+ years of experience in enterprise architecture, solution architecture, systems integration, software engineering, or related technology disciplines.
• Experience designing and implementing AI, Generative AI, machine learning, or intelligent automation solutions.
• Experience developing architecture standards, reference architectures, and technology governance practices.
• Strong understanding of cloud platforms, application integration, enterprise security, and modern software architecture patterns.
• Ability to communicate technical concepts effectively to both technical and non-technical stakeholders.
• 5+ years of leadership, team lead, or architecture influence experience.

Preferred Qualifications

• Enterprise AI architecture expertise with Bedrock, MCP, AI Gateways, LangGraph/LangChain, RAG, and agentic AI platforms.
• Strong architecture and implementation experience across OpenShift/Kubernetes, and scalable AI infrastructure, including deployment, operations, and lifecycle management of long-running agents.
• Knowledge of large language models (LLMs), retrieval-augmented generation (RAG), agent frameworks, vector databases, and AI observability practices.
• Experience with responsible AI, AI governance, security, and compliance frameworks.
• Experience creating reusable frameworks, accelerators, and architecture guidance for enterprise technology teams.

ALSAC is committed to providing flexible work options. This role may be based in a hybrid schedule for candidates located near our Memphis, TN or Coppell, TX offices. For highly qualified candidates in other U.S. locations, remote work arrangements may be available.

Benefits & Perks

The following Benefits & Perks apply to Full-Time Roles Only.

We’re dedicated to ensuring children and their families have every opportunity to enjoy life’s special moments. We’re also committed to giving our staff excellent benefits so they can do the same.

• Core Medical Coverage: (low cost low deductible Medical, Dental, and Vison Insurance plans)
• 401K Retirement Plan with 7% Employer Contribution
• Exceptional Paid Time Off
• Maternity / Paternity Leave
• Infertility Treatment Program
• Adoption Assistance
• Education Assistance
• Enterprise Learning and Development
• And more

ALSAC is an equal employment opportunity employer.

ALSAC does not discriminate against any individual with regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, transgender status, disability, veteran status, genetic information or other protected status.

No Search Firms

ALSAC does not accept unsolicited assistance from search firms for employment opportunities. All resumes submitted by search firms to any ALSAC employee or ALSAC representative via email, the internet or in any form and/or method without being contacted and approved by our Employee Experience team and without a valid written search agreement in place will result in no fee being paid if a referred candidate is hired by ALSAC.