Analytical Chemist

TekWissen ®; Sunnyvale (CA); On-site; USD 41,000 - 52,000; Full time

Job summary

TekWissen LLC is partnering with a leading biotechnology client to hire an experienced Chromatography Process Development Scientist in Sunnyvale, CA. You will support column manufacturing, packing, testing, and qualification, troubleshooting performance issues, and driving continuous improvements across manufacturing and R&D teams.

The role demands hands-on chromatography expertise, a solid background in analytical and polymer chemistry, and the ability to optimize packing parameters, analyze

Qualifications

• Required: Bachelor’s or Master’s in Analytical Chemistry or Polymer Chemistry.
• Minimum 3 years in chromatography, process development, analytical development, or manufacturing support.
• Hands-on chromatography experience and knowledge of resins, silica phases, and surface chemistry.

Responsibilities

• Provide troubleshooting support for chromatography column packing, testing, and qualification failures.
• Investigate chromatographic performance issues: efficiency, peak asymmetry, resolution, retention, and backpressure.
• Analyze chromatograms, pressure profiles, packing parameters, and manufacturing records to identify root causes.
• Differentiate failures related to packing, equipment, testing conditions, stationary-phase properties, and manufacturing processes.
• Optimize column packing parameters including pressure, flow, slurry, and equipment settings.
• Design and execute experiments to improve packing reproducibility and yield.
• Apply polymer chemistry and surface chemistry knowledge to material-related issues.
• Collaborate with Manufacturing, Engineering, Quality, and R&D to resolve challenges.
• Document investigations, findings, and recommendations for improvements.
• Develop, review, and revise SOPs and troubleshooting guides.

Skills

Analytical chemistry

Polymer chemistry

HPLC

Chromatography

Problem-solving

Cross-functional collaboration

Education

Bachelor's or Master's in Analytical Chemistry or Polymer Chemistry

Tools

HPLC

Ion Chromatography

DOE

JMP

Job description

Pay Range: $30 to $38 – Depending on experience

Overview:

TekWissen is a global workforce management provider headquartered in Ann Arbor, Michigan that offers strategic talent solutions to clients worldwide. The job opportunity below is with one of our clients specializing in biotechnology product development services. The client is dedicated to supplying laboratory equipment, chemicals, supplies, and services essential in healthcare, scientific research, safety, and education. As a global leader in serving the scientific community, the organization generates approximately $40 billion in annual revenue and is committed to making the world healthier, cleaner, and safer. Their global team delivers innovative technologies, convenient procurement solutions, and pharmaceutical services through industry-leading brands.

Summary

We are seeking an experienced Chromatography Process Development Scientist to provide hands‑on technical support for chromatography column manufacturing, packing, testing, and qualification processes. This role focuses on troubleshooting column performance issues, investigating manufacturing failures, optimizing packing parameters, and driving continuous process improvements. The ideal candidate will have a strong background in analytical chemistry and polymer chemistry, with hands‑on chromatography experience and a solid understanding of chromatography resins, silica stationary phases, and surface chemistry. The position requires close collaboration with Manufacturing, Engineering, Quality, and R&D teams to improve column performance, manufacturing reproducibility, and process efficiency.

Responsibilities

• Provide day‑to‑day technical troubleshooting support for chromatography column packing, testing, and qualification failures.
• Investigate chromatographic performance issues, including efficiency, peak asymmetry, resolution, retention, selectivity, backpressure, and flow behavior.
• Analyze chromatograms, pressure profiles, packing parameters, manufacturing records, and qualification data to identify root causes of column performance failures.
• Differentiate between failures associated with column packing, equipment, hardware, testing conditions, stationary‑phase properties, and manufacturing processes.
• Optimize column packing parameters, including packing pressure, flow rates, slurry conditions, equipment settings, and critical manufacturing variables.
• Design and execute experiments to improve column packing reproducibility, first‑pass yield, and manufacturing process robustness.
• Apply knowledge of polymer chemistry, chromatography resins, silica materials, and surface chemistry to investigate material‑related performance issues.
• Collaborate with Manufacturing Technicians, Subject Matter Experts (SMEs), Engineering, Quality, and R&D teams to resolve technical and manufacturing challenges.
• Document technical investigations, experimental findings, root cause analyses, and recommendations for process improvements.
• Develop, review, and revise Standard Operating Procedures (SOPs), work instructions, troubleshooting guides, and manufacturing documentation.
• Support training of manufacturing personnel on troubleshooting techniques, process improvements, and updated manufacturing procedures.
• Drive continuous improvement initiatives to enhance column quality, process reliability, and production efficiency.

Required Skills

• Bachelor's or Master's degree in Analytical Chemistry or Polymer Chemistry required.
• Minimum 3 years of relevant industry experience in chromatography, process development, analytical development, or manufacturing technical support.
• Working knowledge of polymer chemistry, including chromatography resins, silica stationary phases, and surface chemistry.
• Hands‑on experience with High‑Performance Liquid Chromatography (HPLC), Ion Chromatography (IC), or related chromatography systems strongly preferred.
• Experience troubleshooting chromatography columns, column packing processes, analytical instruments, or chromatographic performance issues highly desirable.
• Understanding of chromatography principles, including peak resolution, retention, selectivity, column efficiency, flow rates, and backpressure.
• Strong analytical skills with experience interpreting chromatograms, experimental data, and manufacturing performance metrics.
• Experience conducting root cause investigations, troubleshooting technical problems, and implementing process improvements.
• Knowledge of Design of Experiments (DOE), JMP, or statistical data analysis tools is an advantage.
• Experience working in GMP, ISO, or other regulated manufacturing environments preferred.
• Strong technical documentation skills, including preparation of investigation reports, SOPs, and work instructions.
• Excellent communication, problem‑solving, and cross‑functional collaboration skills.
• Ability to work hands‑on with manufacturing personnel, laboratory equipment, and production processes.

TekWissen Group is an equal opportunity employer supporting workforce diversity.