AI & Real World Analytics Senior Manager

Vertex Pharmaceuticals Incorporated; Boston (MA); Hybrid; USD 148,900 - 223,300; Full time

Benefits offered by this job

Educational assistance

Commuting subsidy

401(k)

Charitable matching

Job summary

Vertex Pharmaceuticals Incorporated is seeking an AI and Real-World Analytics Senior Manager in Boston to drive RWA AI/automation initiatives. You will lead RWE projects, optimize processes with AI/ML, and advance data-use strategies for business objectives.

The role requires advanced degrees and 5+ years in observational research with 3+ years in AI/ML data engineering, plus strong Python/SQL and cloud skills (AWS/GCP/Azure).

Qualifications

• Advanced degree in epidemiology, biostatistics, math, data science, or similar disciplines.
• Minimum 5 years in observational research within life sciences or related fields; at least 3 years in AI/ML data engineering and automation.

Responsibilities

• Lead the design, execution, and delivery of Real-World Evidence projects using AI/ML.
• Optimize analytics workflows and data-source intake with AI/ML solutions in partnership with DTE.
• Automate task tracking, resource allocation, and communication at milestones.
• Standardize process documentation using AI/ML to identify gaps and improve outcomes.
• Identify automation opportunities for DAP validation, code generation, QC, and cross-checking; support AI solutions.

Skills

Data science

AI/ML methods

Python

SQL

Azure AI Foundry

AWS/GCP/Azure

Neural networks

Random forests

Observational research

Statistical modeling

Education

Advanced degree

Tools

AWS

GCP

Azure

Job description

Job Description

General Summary:

The AI and Real-World Analytics Senior Manager will play a pivotal role in leading and advancing the RWA team's AI and automation capabilities. This role will focus on driving the development and optimization of the real world data analysis processes.
The position will involve deep diving into Real-World Data (RWD) to generate data expertise, actionable insights, and optimal data use strategies to support business objectives.
The position is responsible for identifying opportunities within the team to enhance automation, standardization, and simplification and partnering with leadership to prioritize them. Then they will gather requirements, and either build agents using enterprise low/no code solutions or partnering with Data, Technology, and Engineering (DTE) to develop and deploy more advanced AI solutions.

Key Duties and Responsibilities

• Lead the design, execution, and delivery of Real-World Evidence (RWE) analysis projects, incorporating AI/ML methodologies
• Optimize and complete processes such as analytics project workflows and data source intake and hosting workflows by identifying inefficiencies and implementing AI/ML-driven solutions in partnership with DTE.
• Streamline project management processes, including request handling, execution, and delivery, to automate task tracking, resource allocation, and communication at key milestones.
• Enhance and standardize process documentation, utilizing AI/ML algorithms to identify common gaps in analytic programs and recommend optimal practices for improved outcomes.
• Identify automation opportunities for tasks like database analysis plan (DAP) validation, medical code list searching, programming plan and code generation, quality control, and result cross-checking. Manage and support internally-developed AI solutions, including access, runbooks, and operational workflows.
• Apply advanced AI/ML techniques to generate deep insights from real-world data (RWD), including benchmarks, representativeness, gaps, and overlaps, and propose innovative solutions to address data capability limitations.
• Partner with the Digital Technology and Engineering (DTE) team to understand the company's AI/ML environment and recommend innovative tools and approaches to improve the RWA team's efficiency and analytical capabilities. Work closely with DTE AI Engineering and AI Operations to establish and implement best practices, standards, and observability.
• Work with DTE to design and execute comprehensive AI/ML model validation strategies, including data splitting, metric selection, cross-validation, robustness testing, fairness audits, and post-deployment monitoring.
• Experienced in providing training and technical support to end users for effective adoption and utilization of AI and automation solutions.
• Shapes the technical strategy of the Real-World Analytics group by providing thought leadership, guiding the adoption of cutting-edge technologies, and encouraging a culture of creativity and continuous improvement within the team.
• Strong understanding of Generative AI ethics and governance frameworks: The candidate should demonstrate knowledge of ethical considerations, responsible AI practices, and governance frameworks related to the development, deployment, and use of Generative AI tools. This includes awareness of potential biases, data privacy concerns, transparency, accountability, and compliance with relevant regulatory and industry standards.

Knowledge and Skills

• Strong knowledge and hands‑on experience in data science and AI/ML methodologies, including supervised, unsupervised, and reinforcement learning, as well as machine learning algorithms such as neural networks and random forests.
• Experience designing, deploying, and supporting AI applications using AWS, GCP, and Azure engineering ecosystems, with specific expertise in Azure AI Foundry.
• Proficiency in statistical programming languages such as Python, SQL, SAS, and R, with familiarity in working within AWS computational environments.
• Knowledge of healthcare claims and electronic health record (EHR) data, with exposure in major U.S. real-world data (RWD) sources.
• Knowledge of statistical modeling and observational research.
• Strong problem‑solving and analytical abilities.
• Excellent communication skills for collaborating with stakeholders and bridging technical and domain teams.
• Experience working in fast‑paced environment.

Education and Experience

• Advanced degrees in epidemiology, biostatistics, math, data science, or similar disciplines required.
• Minimum 5 years of experience working in observational research within the life sciences industry or relevant academic, government, or consulting environment, with at least 3 years of experience in AI/ML related data engineering and automation.

Pay Range

$148,900 - $223,300

Disclosure Statement

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market‑leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week‑long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation

Hybrid‑Eligible Or On‑Site Eligible

Flex Eligibility Status

In this Hybrid‑Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On‑Site: work five days per week on‑site with ad hoc flexibility.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Equal Employment Opportunity

Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail].