Advisor Chemistry

100 Eli Lilly and Company; Pasadena (CA); Presencial; USD 141.000 - 231.000; Jornada completa

Descripción de la vacante

Protomer, a Lilly Research Laboratories unit based in Pasadena, seeks a research scientist with a PhD in chemistry or related field to advance synthesis, bioconjugation, purification and characterization of therapeutic compounds.

You will work cross-functionally to drive development of preclinical and clinical candidates, present in team meetings, and apply strong biochemistry techniques with RNA chemistry experience to contribute to innovative medicine programs.

Formación

• PhD required in chemistry or closely related field.
• Strong background in biochemistry, synthesis and characterization.
• Experience with development and validation of in-vitro biochemical data.

Responsabilidades

• Work closely with Protomer team to accomplish objectives and milestones.
• Purify and characterize compounds using HPLC, FPLC, and biochemical methods.
• Introduce and maintain state-of-the-art technologies for peptide therapeutics and assays.
• Perform data analysis and troubleshoot experiments.
• Demonstrate ability to work independently within cross-functional teams.
• Maintain accurate records and present data in written and oral formats.
• Comply with Lilly Research Policies.
• Contribute to team’s progress and strategic priorities.

Conocimientos

Biochemical techniques

RNA chemistry knowledge

Team collaboration

Educación

PhD degree in chemistry or closely related field

Herramientas

HPLC

FPLC

Bioconjugation techniques

Descripción del empleo

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Organization Overview

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

Protomer

Protomer is a wholly owned subsidiary of Eli Lilly and Co. based in Pasadena, CA. The team operates as a group within Lilly Research Laboratories (LRL). LRL is focused on the discovery and development of new therapeutics for the treatment of a plethora of diseases. The scientists in LRL work cross-functionally between therapeutic target area disciplines, including Diabetes, Heart Failure, Renal, Neuroscience, ASCVD, Incretins and Insulins. The team at Protomer is working on responsive biotherapeutics that can be controlled using small molecule modulators. We are currently expanding the team to advance several programs, including responsive siRNA and ASOs using sensing elements, and are looking for a research scientist with a proven record of accomplishment in chemistry, biochemistry, synthesis, bioconjugations, and purification/characterization of therapeutic compounds of interest. The ideal candidate will have a degree in chemistry, chemical engineering, biochemistry, biology, or a related field, as well as in-depth understanding of basic biochemistry and chemistry techniques and experience with development, validation, and implementation of experiments in a biomedical research setting. Ideal candidate will have great working knowledge of synthetic routes for RNA molecules that can be conjugated or synthesized with small molecule or short peptides. The applicant must be a fast-learning, task-oriented, and self-motivated person who can perform detailed work with minimal supervision. A requirement of this role is to work well as a team player in a fast-paced research setting. The applicant will be responsible for synthesis, bioconjugation, purification, and characterization of compounds of interest. The successful candidate will actively participate and present in team meetings and is expected to contribute to the team’s progress and success. Demonstrated ability to make decisions in the midst of ambiguity, seeking appropriate level of information from Protomer leadership and enabling workforce to execute for and contribute to Protomer team’s strategic priorities. Open, transparent and able to communicate equally well with employees, team members and cross-functional and/or senior leadership. Team oriented mindset, pleasant to work with and a leader that develops next generation talent as well as delivers results. Ability to think strategically, actively identifying gaps in competencies or capabilities within the organization and taking initiative to drive continuous improvement across Protomer.

Responsibilities

• Work closely with the Protomer team to accomplish team objectives and research milestones
• Use knowledge and technical expertise to complement and enable core capabilities and help drive development of preclinical and clinical candidates
• Purify and characterize compounds using HPLC, FPLC, and various biochemical methods
• Introduce and maintain state-of-the-art technologies with respect to peptide therapeutics, including developing and implementing assays and maintaining critical instruments.
• Perform data analysis. Critically evaluate data and results and troubleshooting experiments.
• Demonstrable ability to function independently, work within a team-oriented lab environment, and work within cross-functional project teams.
• Maintain accurate record keeping, perform independent data analysis, and report data in written and oral formats and retain excellent electronic lab notes.
• Perform work in compliance with Lilly Research Policies.
• Demonstrate proactive and flexible behaviors and develop skills for competency in conducting independent research projects.

Basic Qualifications

• PhD degree in chemistry or a closely related field with relevant graduate or post-graduate level research experience.

Additional Skills/Preferences

• Responsibilities will reflect the level of experience and competency of the candidate and can span from early research and development execution to overseeing larger efforts depending on experience
• Proven ability to work in a flexible, team-oriented environment.
• Experience with standard biochemistry techniques in a graduate level academic research setting and preferably in an industry setting.
• Individuals with significant industry experience will be considered and responsibilities will reflect the level of experience of the candidate.
• Experience in the development and validation of in-vitro biochemical and data evaluation, especially in the areas of cardiorenal and metabolic diseases.
• Strong communication skills and experience presenting data in a team environment.
• Strong relationship-building and interaction skills with peers and management.

Additional Information

Some domestic and international travel is anticipated and expected. Work is on-site and the team is located in Pasadena, California. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $141,000 - $231,000 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. #WeAreLilly At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people. We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe! #WeAreLilly