ADME scientist

Artech Information System LLC; Andover (MA); On-site; USD 70,000 - 90,000; Full time

Job summary

A prominent IT staffing company is seeking a skilled scientist for a contractor position in the ADME group. The role involves supporting pre-clinical studies related to biotherapeutics. Responsibilities include sample preparation for PK studies, handling of biological samples, and performing under minimal supervision. Candidates should hold a BS/MS in Biochemistry, Biology, or related fields, and experience in biopharma and handling radioactive materials is preferred. Strong communication skills and collaboration abilities are essential.

Qualifications

• Industry experience in biopharma preferred.
• Experience using radioactive materials (125I, 111In) is strongly preferred.
• Knowledge of IACUC, animal use protocols, PKPD study design and concepts is a plus.

Responsibilities

• Independent sample preparation and analysis for PK/drug studies using gamma counter detection.
• Handling of biological samples, preclinical serum and tissues.
• Summarization and documentation of experiments.

Skills

Strong data organization and analysis skills

Strong interpersonal skills

Fast learner

High level of initiative

Works well independently and in teams

Education

BS/MS in Biochemistry, Biology, Pharmacology or related fields

Tools

Gamma counter detection

SDS-PAGE

Cell culture

Job description

Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost.

Job Description

Job Focus: A contractor position is available for a skilled scientist to join in Pfizer’s Pharmacokinetics Dynamics and Metabolism New Biological Entities (PDM-NBE) ADME group to address diverse and complex scientific ADME issues pertaining to protein biotherapeutics. This lab based role involves the scientific and technical support of in vitro and in vivo pre-clinical studies designed to understand mechanistic ADME characteristics of biotherapeutics which will support the development of predictive pharmacological tools. The candidate will participate in all phases of laboratory operations relating to biotherapeutic PK/tissue distribution/tissue catabolism study execution, sample preparation, and data analysis. We are looking for a scientist passionate about learning and able to quickly apply new skills to the project needs.

Responsibilities

• Independent sample preparation and analysis for in vitro and in vivo radiolabeled PK/drug tissue distribution/tissue catabolism studies using appropriate method of analysis (primarily gamma counter detection).
• Handling of biological samples, preclinical serum and tissues.
• Occasional use of cell culture, SDS-PAGE, or binding assays may be required.
• Perform under minimal supervision; initiative in method development is expected.
• Independent daily operation, calibration, maintenance, and trouble shooting of instrumentation.
• Summarization and documentation of experiments.

Qualifications, Technical Skills and Experience

• BS/MS level education in Biochemistry, Biology, Pharmacology or closely related fields required.
• Industry experience in biopharma preferred.
• Experience using radioactive materials (125I, 111In) is strongly preferred.
• Experience with SDS-PAGE, binding assays, or cell culture is a plus.
• Knowledge of IACUC, animal use protocols, PKPD study design and concepts is a plus.
• High level of initiative in performing experiments, multi-tasking and troubleshooting.
• Fast learner and be able to master running/maintaining instruments after a short period of training.
• Strong interpersonal skills, communication (verbal and written).
• Works well both independently and as part of a team. Collaborative skills and effective partnering skills in a matrix-environment is necessary.
• Strong data organization and analysis skills.