Vice President, Pharmacology

Hummingbird Bioscience; Singapore; On-site; SGD 300,000 - 600,000; Full time

Benefits offered by this job

Health insurance

On-site meals and snacks

Job summary

Hummingbird Bioscience in Singapore is seeking an accomplished drug development leader as Vice President, Pharmacology to guide non-clinical pharmacology and translational science for antibody therapeutics in oncology and inflammation. This Singapore-based role reports to the Chief Scientific Officer and oversees pharmacology strategy from lead selection to IND/CTA submission.

The successful candidate will integrate MoA, target engagement, PK/PD, biomarkers, and safety across a biologics

Qualifications

• PhD/MD/PharmD or equivalent in Pharmacology, Cancer Biology, Immunology, Molecular Biology, Drug Development or related field.
• 15+ years in biotech/pharma with pharmacology, translational science and drug development leadership.
• Broad drug development experience in oncology and I&I, with models, endpoints and development considerations.
• Substantial experience with antibody-based therapeutics (mAbs, bispecifics, ADCs).
• Experience authoring and coordinating pharmacology content for regulatory submissions and responses.

Responsibilities

• Define pharmacology strategy translating biology into integrated decision frameworks with clear criteria for candidate selection and portfolio prioritization.
• Lead pharmacology organization, empower multidisciplinary teams, and manage CROs and external partnerships.
• Deliver IND/CTA-enabling pharmacology packages including MoA, target engagement, PK/PD and translational biomarkers.
• Lead regulatory submissions and health authority interactions, ensuring data traceability and quality.
• Support early clinical translation with translational strategy, dose-exploration hypotheses, and patient selection.
• Represent Pharmacology in cross-functional teams, communicate risks and recommendations to executives and partners.

Skills

Leadership

Cross-functional collaboration

Regulatory submissions

Translational science

Biologics experience

Communications

Education

PhD/MD/PharmD or equivalent

Job description

Hummingbird Bioscience is an AI-driven drug development company working at the interface of artificial intelligence and human innovation to discover and develop transformative medicines for hard-to-treat diseases. Hummingbird Bioscience’s computational and systems biology technologies have generated a pipeline of innovative clinical-stage monoclonal antibodies and antibody-drug conjugates in oncology and autoimmunity.

For more information, please visit www.hummingbirdbioscience.com, and follow Hummingbird Bioscience on LinkedIn, X (formerly Twitter), and YouTube.

ABOUT THE ROLE

Hummingbird Bioscience is seeking an accomplished drug development leader as Vice President, Pharmacology to lead non-clinical pharmacology and translational science across our portfolio of antibody therapeutics in oncology and inflammation & immunology. This is a Singapore-based role reporting to the Chief Scientific Officer. The executive will have end-to-end accountability for pharmacology strategy from lead selection through IND/CTA submission and early clinical translation.

The successful candidate will bring broad drug development experience across oncology and I&I, a strong track record with biologics, and the judgment to integrate mechanism-of-action, proof-of-concept efficacy, target engagement, PK/PD, translational biomarker, and safety-relevant data into a coherent development and regulatory package. This leader will play a critical role in shaping portfolio strategy, driving translational and biomarker initiatives, building high-performing teams, enabling the advancement of innovative precision medicines for patients with high unmet medical needs.

KEY RESPONSIBILITIES

• Define the pharmacology strategy: Translate target and disease biology into integrated decision-making frameworks with clear decision criteria that enable rigorous candidate selection, mechanism-of-action validation, and portfolio prioritization across the pipeline.
• Lead an exceptional pharmacology organization and operating model: Develop and empower a multidisciplinary team across in vitro and in vivo pharmacology, fostering a culture of scientific rigor, accountability, innovation, and cross-functional collaboration. Extend capabilities through high-quality CRO, academic, advisor, and other external partnerships. Manage departmental resources, budgets, and strategic priorities to ensure efficient execution across a diverse and growing portfolio.
• Deliver the IND/CTA-enabling pharmacology package: Direct fit-for-purpose in vitro and in vivo studies spanning mechanism of action, target engagement, proof-of-concept efficacy, PK/PD and exposure-response, translational biomarkers, and safety-relevant pharmacology. Integrate pharmacology findings with DMPK, toxicology, and safety pharmacology to select development candidates, characterize risk, and establish the human dose and regimen rationale.
• Lead regulatory submissions and health authority interactions: Author, review, and coordinate the relevant pharmacology sections, nonclinical summaries, and supporting reports for IND/CTA and other submissions; ensure scientific consistency, quality, and data traceability; and lead responses to pharmacology-related regulatory questions.
• Support early clinical translation: Partner with Bioinformatics, Regulatory, Clinical Development, and other functions to define translational and patient-selection strategies, dose-escalation and expansion hypotheses, and early clinical proof-of-concept plans.
• Guide program and portfolio decisions: Represent Pharmacology on cross-functional program and portfolio teams, synthesize evidence across disciplines, surface scientific and development risks, and communicate clear recommendations to executive, Board, partner, and investor audiences as appropriate.

REQUIRED QUALIFICATIONS

• Education: PhD, MD, PharmD, or equivalent advanced degree in Pharmacology, Cancer Biology, Immunology, Molecular Biology, Drug Development, or a related scientific discipline.
• 15+ years of relevant biotechnology or pharmaceutical industry experience, including progressive leadership in pharmacology, translational science, and drug development.
• Broad drug development experience across oncology and I&I, with substantial understanding of disease biology, relevant models, translational endpoints, and development considerations in both therapeutic areas.
• Substantial experience with antibody-based therapeutics, including monoclonal antibodies, multi-specific antibodies, and/or ADCs.
• Deep command of integrated non-clinical pharmacology packages, including mechanism of action, proof-of-concept efficacy, target engagement, PK/PD and exposure-response, dose and regimen rationale, translational biomarkers, and interfaces with toxicology and safety pharmacology.
• Direct experience authoring and coordinating pharmacology content for regulatory submissions and responding to health authority questions.
• Proven leadership of multidisciplinary teams in a matrixed environment, including budgets, resources, CROs, and external collaborations, with the communication skills to influence scientific, executive, regulatory, and partner stakeholders.

Preferred Experience

• Leadership experience in a clinical-stage biotechnology company and a record of scientific publications, presentations, and engagement with external experts or key opinion leaders.
• Experience with global health authority interactions and later-stage biologics filings or life-cycle submissions, including BLA/MAA or equivalent.
• Experience supporting asset evaluation, due diligence, licensing, strategic partnerships, business development, and/or financing activities.
• Strategic thinker who connects scientific insight to portfolio and business objectives.
• Strong scientific judgment, with the ability to make timely, data-driven decisions under uncertainty.
• Demonstrated success leading, mentoring, and developing high-performing scientific teams.
• Exceptional communicator who can engage scientific, executive and partner audiences with clarity and credibility.

OUR MISSION & VALUES

Our fast-growing biotechnology company is committed to discovering and developing important new drugs for cancer and autoimmune diseases, and living by our values: Excellence, Determination, Teamwork, Intellectual Integrity and Audacity.

JOIN US AT THE FRONTIER OF DRUG DISCOVERY AND DEVELOPMENT

We are looking for passionate and motivated individuals committed to solving important, complex problems. We are committed to the personal and professional development of our team and offer robust learning and development programs. Hummingbird Bioscience understands the need for flexibility for our team and offers a generous paid time off program with flexibility to support employees through different life stages. We invest in our team’s health by offering competitive benefits including health and dental insurance, and a comprehensive and holistic employee assistance program. We foster a more collaborative, productive, and sociable culture with on-site lunches and snacks. Finally, we believe in creating social impact beyond our business through corporate social responsibility initiatives.

For further enquiries, please email us at [e-mail].

Hummingbird Bioscience is firmly committed to Equal Employment Opportunity (EEO) and to compliance with all Singapore and US federal, state and local laws and/or guidelines that prohibit employment discrimination on the basis of age, race, color, gender, sexual orientation, gender identity, ethnicity, national origin, citizenship, religion, genetic carrier status, disability, pregnancy, childbirth or related medical conditions, marital status, protected veteran status and other protected classifications.