Senior Scientist, Nucleic Acid Therapeutics

A*STAR RESEARCH ENTITIES; Singapore; On-site; SGD 120,000 - 180,000; Full time

Job summary

GIS, A*STAR’s YUcleic Lab invites applications for a Scientist or Senior Scientist to develop therapeutic strategies targeting RNA and DNA. You will lead multidisciplinary projects, shape new directions, and contribute to emerging RNA- and DNA-targeted platforms in a national genomics environment.

The role offers opportunities to publish, obtain grant support, mentor researchers, and collaborate with biologists, chemists, and computational scientists to translate fundamental discoveries into

Qualifications

• PhD in RNA biology, nucleic acid biology, functional genomics, molecular biology, pharmacology, or a related field.
• Strong knowledge of RNA regulation and gene-expression control.
• Hands-on experience with CRISPR, CLIP-seq, ChIP-seq, Ribo-seq, RNA-seq, co-IP, western blotting, reporter assays, or cellular screening.
• Strong scientific writing, presentation, and project-management skills.
• Independent, collaborative, and motivated to explore innovative therapeutic strategies.

Responsibilities

• Develop and test innovative hypotheses in nucleic acid biology and therapeutics.
• Design mechanistic and functional studies in disease-relevant cellular models.
• Establish screening platforms to identify regulatory factors, ASOs, and small molecules.
• Apply functional genomics and sequencing-based approaches.
• Collaborate with biologists, chemists, and computational scientists.
• Lead research projects, mentor junior researchers, and contribute to publications and grant proposals.

Skills

RNA regulation

CRISPR

Cellular screening

Scientific writing

Project management

Education

PhD in RNA biology or related field

Tools

CRISPR

CLIP-seq

ChIP-seq

Ribo-seq

RNA-seq

co-IP

Western blot

Reporter assays

Job description

GIS, A*STAR’s YUcleic Lab invites applications for a Scientist or Senior Scientist to develop therapeutic strategies targeting RNA and DNA. You will lead multidisciplinary projects, shape new directions, and contribute to emerging RNA- and DNA-targeted platforms in a national genomics environment.

The role offers opportunities to publish, obtain grant support, mentor researchers, and collaborate with biologists, chemists, and computational scientists to translate fundamental discoveries into