Senior / Scientist (FDG), BTI

Agency for Science, Technology and Research (A*STAR); Singapore; On-site; USD 60,000 - 100,000; Full time

Job summary

An established industry player is seeking a highly motivated PhD graduate to join their innovative team. This role focuses on the preparation and evaluation of mRNA-loaded nanoparticles for gene delivery, utilizing advanced microfluidic technology. You will conduct critical in vitro and in vivo studies, including toxicity assessments and biodistribution analyses, contributing to groundbreaking research in drug delivery systems. The ideal candidate will thrive in a collaborative environment, demonstrating strong communication skills and the ability to work independently. Join a dynamic team dedicated to advancing scientific research and making a significant impact in the field.

Qualifications

• PhD in relevant fields such as drug delivery or biomaterials is required.
• Familiarity with non-viral nanoparticles for gene delivery is essential.

Responsibilities

• Prepare mRNA-loaded nanoparticles using a microfluidic device.
• Conduct in vitro and in vivo studies on gene transfection efficiency.

Skills

Gene delivery

Interpersonal skills

Communication skills

Independent work

Education

PhD in drug/gene delivery

PhD in pharmaceutical science

PhD in biomaterials

PhD in biomaterial science

Tools

Microfluidic device

Job description

Job Description:

1. Preparation of mRNA-loaded polymeric or lipid nanoparticles using a microfluidic device.
2. Evaluation of in vitro and in vivo gene transfection efficiency induced by the nanoparticles via intramuscular injection, subcutaneous, or intravenous injection.
3. In vitro and in vivo toxicity studies.
4. In vivo biodistribution studies.
5. Participate in maintenance of equipment and procurement of consumables used for this project.
6. Participate in lab safety and general housekeeping of the lab.

Requirements:

1. PhD in drug/gene delivery, pharmaceutical science, biomaterials, or biomaterial science.
2. Familiarity in gene delivery with non-viral nanoparticles.
3. Highly motivated and able to work independently.
4. Team player with good interpersonal skills.
5. Good spoken and written communication skills.