Senior Research Fellow (Lipid or Polymer Formulation)

Nanyang Technological University; Singapore; On-site; SGD 90,000 - 140,000; Full time

Job summary

The Laboratory for RNA Delivery Therapeutics at Nanyang Technological University (NTU) Singapore seeks a Senior Research Fellow to advance lipid- and polymer-based RNA delivery systems. You will lead formulation, characterization, and evaluation efforts, while guiding students and contributing to proposals.

Ideal candidates hold a PhD in a relevant field with a strong publication record and experience mentoring researchers; hands-on bioimaging and in vivo study expertise are valued.

Qualifications

• PhD in Chemistry, Chemical Engineering, Materials Science, Bioengineering, or a related discipline.
• Experience in stimuli-responsive RNA delivery, lipid/polymer nanoparticle formulation, and RNA delivery evaluation.
• Hands-on experience in lipid or polymer formulation, bioimaging techniques (e.g. confocal microscopy, FRET, FRAP), and/or in vivo studies.
• Good publication record, communication skills, and ability to conduct independent research.
• Experience in mentoring junior researchers, graduate students, or research staff will be an advantage.
• Experience in successful proposal writings shall also be an advantage.

Responsibilities

• Develop and optimize stimuli-responsive nanoparticle formulations for RNA delivery.
• Formulate lipid- or polymer-based nanoparticles with RNA cargo.
• Characterize nanoparticle physicochemical properties and formulation performance.
• Evaluate RNA transfection efficiency and endosomal escape.
• Conduct bioimaging studies of mammalian cells and RNA delivery formulations.
• Perform in vivo studies using relevant animal models.
• Analyze and interpret experimental data, including nanoparticle and delivery performance measurements.
• Besides, the senior RF is expected to supervise undergraduate FYP, Masters, and PHD students in their works.
• The senior RF is also expected to assist in proposal writings.

Skills

Stimuli-responsive RNA delivery

Lipid/polymer nanoparticle formulation

RNA delivery evaluation

Publication record

Communication skills

Independent research ability

Mentoring junior researchers

Proposal writings

Education

PhD in Chemistry, Chemical Engineering, Materials Science, Bioengineering or related discipline

Tools

Confocal microscopy

FRET

FRAP

In vivo studies

Job description

The Laboratory for RNA Delivery Therapeutics is an inter-school research laboratory across the College of Engineering and College of Science at Nanyang Technological University (NTU), focusing on the development of advanced RNA delivery technologies. The laboratory's research focuses on the design, synthesis and evaluation of novel lipid- and polymer-based delivery systems for RNA therapeutics, with particular emphasis on enhancing delivery efficiency and endosomal escape. The laboratory is led by Prof Mary Chan-Park, President's Chair Professor at NTU Singapore and Director of the Laboratory for RNA Delivery Therapeutics. The research programme includes collaborations with leading international partners to advance next-generation RNA nanomedicines. For more details, please view: https://www3.ntu.edu.sg/home/mbechan/

Key Job Purpose:

We are looking for a Senior Research Fellow to conduct research on the development of novel lipid- and polymer-based delivery systems for RNA therapeutics.

Key Responsibilities:

• Develop and optimize stimuli-responsive nanoparticle formulations for RNA delivery.
• Formulate lipid- or polymer-based nanoparticles with RNA cargo.
• Characterize nanoparticle physicochemical properties and formulation performance.
• Evaluate RNA transfection efficiency and endosomal escape.
• Conduct bioimaging studies of mammalian cells and RNA delivery formulations.
• Perform in vivo studies using relevant animal models.
• Analyze and interpret experimental data, including nanoparticle and delivery performance measurements.
• Besides, the senior RF is expected to supervise undergraduate FYP, Masters, and PHD students in their works.
• The senior RF is also expected to assist in proposal writings.

Job Requirements:

• PhD in Chemistry, Chemical Engineering, Materials Science, Bioengineering, or a related discipline.
• Research experience in stimuli-responsive RNA delivery, lipid/polymer nanoparticle formulation, and RNA delivery evaluation.
• Hands-on experience in lipid or polymer formulation, bioimaging techniques (e.g. confocal microscopy, FRET, FRAP), and/or in vivo studies.
• Good publication record, communication skills, and ability to conduct independent research.
• Experience in mentoring junior researchers, graduate students, or research staff will be an advantage.
• Experience in successful proposal writings shall also be an advantage.

Hiring Institution:

NTU A research-intensive public university, Nanyang Technological University, Singapore (NTU Singapore) has 33,000 undergraduate and postgraduate students in the Engineering, Business, Science, Humanities, Arts, & Social Sciences, and Graduate colleges. It also has a medical school, the Lee Kong Chian School of Medicine, established jointly with Imperial College London. NTU is also home to world-class autonomous institutes – the National Institute of Education, S Rajaratnam School of International Studies, Earth Observatory of Singapore, and Singapore Centre for Environmental Life Sciences Engineering – and various leading research centres such as the Nanyang Environment & Water Research Institute (NEWRI) and Energy Research Institute @ NTU (ERI@N). Ranked amongst the world’s top universities by QS, NTU has also been named the world’s top young university for the past seven years. The University’s main campus is frequently listed among the Top 15 most beautiful university campuses in the world and has 57 Green Mark-certified (equivalent to LEED-certified) buildings, of which 95% are certified Green Mark Platinum. Apart from its main campus, NTU also has a campus in Novena, Singapore’s healthcare district. Under the NTU Smart Campus vision, the University harnesses the power of digital technology and tech-enabled solutions to support better learning and living experiences, the discovery of new knowledge, and the sustainability of resources.

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