Senior Process Engineer, MSAT (Upstream/Downstream)

recruit123 pte. ltd.; Singapore; On-site; SGD 150,000 - 190,000; Full time

Job summary

Recruit123 is seeking a Senior Process Engineer, MSAT to bridge process development and commercial manufacturing for biologics. You will lead tech transfer activities, define scale-up/down parameters for bioreactors and purification platforms, and drive CPV and process verification lifecycle.

The role requires 5–8 years in MSAT/process engineering within a regulated biopharma environment, with deep expertise in either upstream culture or downstream purification and strong data analysis skills

Qualifications

• Degree or postgraduate in Chemical Engineering, Biochemical Engineering, Biotechnology, or related.
• 5–8 years MSAT or process engineering in regulated biopharma (cGMP).
• Strong expertise in upstream cell culture or downstream purification.
• Experience with scale-up, tech transfer, and data analysis.

Responsibilities

• Lead end-to-end technical support for commercial and clinical-scale biologics production.
• Define scale-up and scale-down parameters for bioreactor systems or downstream purification platforms (chromatography, TFF/UFDF, filtration).
• Execute process validation protocols and lead RCA and deviation investigations.
• Design small-scale experiments and author technical memos, change controls, and regulatory filings.
• Collaborate with Manufacturing, Quality, Regulatory, and Global MSAT teams to implement improvements and SPC models.

Skills

MSAT

Process engineering

Tech transfer

Statistical analysis

Cross-functional leadership

Education

Chemical Engineering degree

Biochemical/Biotech background

Tools

Minitab

JMP

SIMCA

Job description

Recruit123 is currently partnering with a leading global biopharmaceutical manufacturer to hire a Senior Process Engineer, MSAT (Manufacturing Science and Technology).

This is an exciting opportunity to serve as the technical subject matter expert (SME) bridging process development and commercial manufacturing, driving technology transfers, process lifecycle management, and complex technical troubleshooting for both upstream and downstream unit operations.

What you will be doing:

In this role, you will lead end-to-end technical support for commercial and clinical-scale biologics production, ensuring robust process performance, yield optimization, and continuous process verification (CPV).

Your main day-to-day responsibilities will include leading tech transfer activities, defining scale-up and scale-down parameters for bioreactor systems or downstream purification platforms (chromatography, TFF/UFDF, filtration), and executing process validation protocols. You will spearhead root cause analyses (RCA) and complex deviation investigations, design small-scale laboratory experiments to troubleshoot floor issues, and author comprehensive technical justification memos, change controls, and regulatory filings.

Additionally, you will partner cross-functionally with Manufacturing, Quality, Regulatory, and Global MSAT teams to implement process improvements, statistical process control (SPC) models, and advanced manufacturing technologies.

What we are looking for:

We are seeking candidates with a degree or postgraduate qualification in Chemical Engineering, Biochemical Engineering, Biotechnology, or a related discipline, alongside at least 5 to 8 years of MSAT or process engineering experience within a regulated cGMP biopharmaceutical environment.

You should demonstrate deep technical mastery in either upstream cell culture/fermentation or downstream purification, accompanied by proven expertise in scale-up methodologies, tech transfer execution, and statistical data analysis (e.g., Minitab, JMP, SIMCA).

Strong stakeholder management, high-level technical writing capabilities, and the agility to navigate fast-paced operational challenges and cross-functional leadership are essential.