Senior Manager (Upstream), MSAT

Biopharma Careers; Singapore; On-site; SGD 180,000 - 280,000; Full time

Job summary

Sanofi is seeking a Senior Manager, Upstream MSAT (Modulus Singapore) to lead a high-performing team focused on upstream biopharmaceutical processes, technology transfer, and continuous improvement. You will partner with global technical teams to ensure robust processes and successful project delivery in a dynamic manufacturing environment.

The role emphasizes leadership, cross-functional collaboration, and driving innovation in upstream process platforms, with accountability for budget and

Qualifications

• Strong leadership with strategic vision and operational mindset.
• Excellent communication across diverse, multicultural teams.
• Analytical, data-driven problem solving and decision making.
• Self-directed with ability to lead initiatives independently.

Responsibilities

• Lead and develop a high-performing MSAT upstream team.
• Define team structure, workflows and deliverables for process transfer and manufacturing support.
• Oversee validation strategies, CAPA and investigations to ensure process robustness.
• Drive process and technology transfer programs and CPV initiatives.

Skills

Leadership

Strategic vision

Cross-functional communication

Analytical thinking

Autonomous work style

Education

Biotechnology / Biological Sciences / Chemical Engineering degree

Job description

Manufacturing Sciences, Analytics and Technology (MSAT) drives the industrialization and continuous improvement of biological processes and products. The function adopts new technologies and digital innovations while serving as the custodian of manufacturing process knowledge.

Positioned at the intersection of R&D and manufacturing, MSAT is a multidisciplinary function providing expertise in process sciences, manufacturing, process modelling, statistical analysis, validation, and technology transfer.

The Senior Manager, Upstream MSAT (Modulus Singapore) holds decision-making authority across key areas including talent management, team development, and budget allocation. From a technical perspective, the role is accountable for upstream process platforms and material-related decisions across process transfer, validation, manufacturing support, and investigations.

This role also drives innovation through the implementation of new technologies and materials, while ensuring process robustness, optimization, and continuous platform improvement.

Key Responsibilities

1. Team Leadership & Development

• Build, lead, and develop a high-performing team of MSAT upstream scientists and engineers.
• Define team structure, workflows, and deliverables to support process transfer and manufacturing operations.
• Coach and develop team members, fostering a culture of accountability, continuous improvement, and open communication.
• Drive employee engagement and enhance the organization’s attractiveness for talent in Singapore’s manufacturing sciences landscape.

2. Process Transfer & Project Leadership

Develop upstream process and engineering strategies to ensure consistency across products and platforms.

Establish systems and tools for standardization and knowledge management.

Lead site- or team-level programs/projects, including:

• Defining manufacturing processes
• Establishing validation and control strategies
• Authoring complex technical documents and regulatory inputs
• Ensure delivery of projects on time, within budget, and to quality standards.

3. Manufacturing Support

Organize MSAT upstream support to meet manufacturing needs, including after-hours on-call support.

Provide scientific expertise for routine operations and troubleshooting.

Lead complex investigations, assessments, and CAPA activities.

Ensure upstream process robustness for assigned products.

Drive Continued Process Verification (CPV) activities.

4. Lifecycle Management & Innovation

Act as the primary site contact for assigned products, ensuring alignment with global technical teams.

Lead initiatives for process and program improvements, including yield optimization and new technology implementation.

Serve as a subject matter expert and potentially a network-level key opinion leader.

Requirements

Core Competencies

• Strong leadership with strategic vision and operational mindset.
• Effective communicator in cross-functional and multicultural environments.
• Excellent analytical and problem-solving capabilities with a data-driven approach.
• Self-directed with the ability to work autonomously and drive initiatives.
• Scientifically curious with a continuous improvement mindset.

Technical & Educational Background

Degree (or higher) in Biotechnology, Biological Sciences, Chemical Engineering, or related field.

Extensive industry experience in mammalian biopharmaceutical processes, including:

• Process engineering
• Technology transfer
• Process validation
• Manufacturing support

Strong understanding of upstream processes and parameter interactions.

Hands-on experience in pilot-scale or large-scale manufacturing environments (cell culture and/or purification).

Solid knowledge of cGMP requirements and current regulatory expectations.

Pursue progress , discover extraordinary

Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.

At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.

Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com !