Senior/Postdoctoral Associate (Immune Cell Biology, Process Development and Clinical Applications)

Singapore-MIT Alliance for Research and Technology; Singapore; On-site; SGD 60,000 - 90,000; Full time

Job summary

Singapore-MIT Alliance for Research and Technology is seeking a Senior/Postdoctoral Associate to advance immune cell biology, process development, and clinical applications for CAR-T cell therapies at SMART CAMP in Singapore. The role focuses on rapid T cell isolation, genetic manipulation, and scalable culture under safety-regulated conditions.

The candidate will collaborate with engineers, biologists, clinicians, and GMP specialists across MIT and Singapore institutions to push translational

Qualifications

• Ph.D. in Immunology, Cell Biology, Cell Process Engineering, or a closely related field.
• Experience with primary T cell isolation and culture, flow cytometry/FACS, and other means of immune cell characterization (microscopy, ELISA, functional assays, etc.)
• Experience with engineered T cells (CAR-T, TCR-T, etc)
• Able to work well and communicate ideas effectively in a multidisciplinary team of researchers with different training backgrounds
• Good track record of publications and scientific output
• Self-motivated, independent, with superior organizational and analytical skills

Responsibilities

• Establish new methods for rapid T cell isolation, genetic manipulation, and culturing.
• Coordinate T cell production and characterization to facilitate a wide array of projects within CAMP, including identifying novel attributes for T cell efficacy, safety, and manufacturability.
• Interface with a diverse array of CAMP teammates and the larger Singapore cell manufacturing community, ranging from engineers to clinicians to GMP manufacturers and regulatory scientists.

Skills

Immunology

Cell biology

CAR-T

Flow cytometry

T cell culture

Team communication

Education

Ph.D. in Immunology

Ph.D. in Cell Biology

Ph.D. in Cell Process Engineering

Tools

Flow cytometry (FACS)

ELISA

Microscopy

Genetic manipulation

Job description

• Senior/Postdoctoral Associate (Immune Cell Biology, Process Development and Clinical Applications)

Senior/Postdoctoral Associate (Immune Cell Biology, Process Development and Clinical Applications)

SMART CAMP (Critical Analytics for Manufacturing Personalized-Medicine) is an interdisciplinary research programme in Singapore (CREATE international research campus and innovation hub) and at the Massachusetts Institute of Technology (MIT). SMART CAMP addresses key technology bottlenecks in cell therapy manufacturing: (i) critical quality attributes (CQA) of safe, effective cell therapy products; and (ii) integrated process analytics to monitor and modulate those attributes.

This interdisciplinary team comprises engineers, biologists, clinicians, manufacturing, and data analytics experts from multiple MIT academic units, and multiple Singapore-based universities, research centres of excellence, and hospitals who are experienced at translational demonstrations of technologies in safety-regulated industries such as cell therapies.

SMART, MIT’s first such research unit outside of Cambridge, MA, serves as an intellectual hub, allowing faculty, researchers and graduate students from MIT to collaborate with their academic and industrial counterparts from Singapore and the region in exciting new areas of science and technology.

Responsibilities

SMART CAMP research will focus on improving the potency, safety, and scalability of manufacturing cell therapies. In particular, this position is focused upon next-generation methods to manufacture CAR-T cells for cancer treatment. This PDA/Sr PDAwill contribute expertise in immune cell biology, process development, and clinical applications, to:

• Establish new methods for rapid T cell isolation, genetic manipulation, and culturing.
• Coordinate T cell production and characterization to facilitate a wide array of projects within CAMP, including identifying novel attributes for T cell efficacy, safety, and manufacturability.
• Interface with a diverse array of CAMP teammates and the larger Singapore cell manufacturing community, ranging from engineers to clinicians to GMP manufacturers and regulatory scientists.

Requirements

• Ph.D. in Immunology, Cell Biology, Cell Process Engineering, or a closely related field
• Experience with primary T cell isolation and culture, flow cytometry/FACS, and other means of immune cell characterization (microscopy, ELISA, functional assays, etc.)
• Experience with engineered T cells (CAR-T, TCR-T, etc)
• Able to work well and communicate ideas effectively in a multidisciplinary team of researchers with different training backgrounds
• Good track record of publications and scientific output
• Self-motivated, independent, with superior organizational and analytical skills