Scientist / Senior Scientist, Chemical Biology (GIS)

Agency for Science, Technology and Research (A*STAR); Singapore; On-site; SGD 60,000 - 100,000; Full time

Job summary

An innovative lab at a leading genomic institute is seeking a passionate Scientist (Postdoctoral Fellow) to drive groundbreaking RNA and DNA-targeted therapeutic discoveries. This role involves designing functional genomics experiments and collaborating with experts in the field to explore cutting-edge strategies for gene regulation. By joining this dynamic team, you will contribute to pioneering research that addresses genomic dysregulation and enhances public health. With a commitment to scientific innovation and a vibrant work environment, this opportunity promises to be both rewarding and impactful.

Benefits

Relocation Assistance

Competitive Remuneration Package

World-Class Research Infrastructure

Qualifications

• PhD in relevant fields with strong expertise in wet lab research.
• Experience in nucleic acids research and CRISPR approaches is a plus.

Responsibilities

• Design and execute functional genomics experiments and ASO-based strategies.
• Collaborate with biologists to identify RNA-targeting ASOs and small molecules.

Skills

Molecular Biology

RNA Biology

Chemical Biology

Functional Genomics

Project Management

Scientific Writing

Education

PhD in Biology

PhD in Chemical Biology

PhD in Genetics

Tools

CRISPR

Sequencing Technologies

Job description

Join the Chemical Biology lab (Zutao Yu Lab) at GIS: Unlocking the Therapeutic Potential of targeting RNA and DNA

The Yu Lab (launching in April 2025) at the Genome Institute of Singapore (GIS), A*STAR, is a chemical biology lab dedicated to translational research targeting cellular nucleic acids. We integrate functional genomics, chemical biology, and molecular pharmacology to advance RNA- and DNA-targeted drug discovery. Our goal is to re-engineer small molecules and antisense oligonucleotides (ASOs) for gene-selective regulation, paving the way for rational drug design. By leveraging cutting-edge gene-targeting strategies, structural biology, sequencing technologies, and computational approaches, we aim to unlock RNA and DNA as precise therapeutic targets, addressing diseases linked to genomic dysregulation and undruggable pathways.

Why Join Us?

The Genome Institute of Singapore (GIS), A*STAR is the national flagship program for genomic sciences in Singapore, with a mission to use genomics to improve public health and drive biomedical innovation. GIS offers a highly competitive remuneration package and relocation assistance. Singapore is a vibrant, cosmopolitan city-state at the heart of Asia, known for its excellent quality of life, world-class research infrastructure, and strong government support for scientific innovation.

We are looking for a highly motivated Scientist (Postdoctoral Fellow) to join our team and contribute to innovative RNA- and DNA-targeted therapeutic discovery.

Scientist / Senior Scientist (2-year contract, renewable)

Responsibilities:

• Design and execute functional genomics experiments, including CRISPR-, small molecule-, and ASO-based gene regulation strategies.
• Develop and refine chemical biology approaches to investigate DNA- and RNA-small molecule interactions.
• Integrate transcriptomics and genomics data to study small-molecule targeting at the transcriptome and genome level (prior experience is a plus but not required).
• Collaborate with biologists and chemists to identify RNA-targeting ASOs and small molecules with therapeutic potential.
• Lead research projects, mentor junior researchers, and contribute to manuscripts and grant writing.

Requirements:

• PhD in Biology, Chemical Biology, Genetics, or a related field.
• Strong expertise in wet lab research, including molecular biology, RNA biology, chemical biology, or functional genomics.
• Experience in nucleic acids research, CRISPR-dCas9/13 approaches, chemical design, or sequencing technologies.
• Strong scientific writing, presentation, and project management skills.
• Highly motivated, collaborative, and eager to explore innovative therapeutic strategies.

Application Details

For inquiries or to apply, please email your CV and brief research interest to Zutao Yu ([e-mail]; [e-mail]). More information about the lab can be found online: www.yucleiclab.com and https://www.researchgate.net/profile/Yu-Zutao.

Join us in advancing RNA and DNA-targeted therapeutics and making an impact in functional genomic medicine!