Research Officer/ Senior Research Officer (Ref: NHCS/RO/D)

NATIONAL HEART CENTRE OF SINGAPORE PTE LTD; Singapore; On-site; SGD 56,000 - 89,000; Full time

Job summary

National Heart Centre of Singapore PTE LTD's NHCS research team invites applications for a role in the Heart Protection program. You will support therapeutic development and perform molecular experiments and formulation work, including RNA synthesis and lipid nanoparticle formulation, within a multidisciplinary team.

You will conduct in vitro assays, cell culture, and analyses, and contribute to in vivo validation as needed.

Qualifications

• Bachelor’s degree in chemistry/Materials Science, Molecular Biology, Biomedical Science, or related fields.
• At least 2 years’ experience in RNA therapeutics/RNA synthesis/RNA biology, or chemical synthesis/LNP delivery.
• Strong hands-on laboratory skills and experimental troubleshooting ability.
• Good communication and organisational skills.
• Vaccination proof: Measles/MMR and Tdap vaccination within the last 10 years or commitment to complete before work start.

Responsibilities

• Support ongoing research projects in therapeutic development and contribute to molecular experiments and formulation work.
• Conduct in vitro assays including cell culture, molecular analysis, and characterisation; participate in in vivo validation.
• Maintain accurate laboratory records and ensure proper documentation throughout.
• Support general lab operations — reagent preparation, equipment maintenance, and purchasing — within a multidisciplinary team.

Skills

RNA techniques

Lab troubleshooting

Communication

Organisational skills

Education

Bachelor’s degree in chemistry/ Materials Science, Molecular Biology, Biomedical Science, or related fields

Tools

LNP formulation

RNA synthesis tools

Job description

You will be part of the research team under the Heart Protection theme at the National Heart Research Institute of Singapore (NHRIS), National Heart Centre of Singapore (NHCS), dedicated to developing innovative strategies to prevent and treat heart injury. Our multidisciplinary group integrates cardiovascular biology, nanotechnology, drug delivery, disease modelling, and translational science, collaborating closely with clinicians, engineers, and scientists across NHCS and Duke–NUS to accelerate the development of therapies from bench to bedside. Our team culture values rigour, teamwork, innovation, and translational impact, offering a dynamic environment for scientific growth.

You will support ongoing research projects in therapeutic development and contribute to a range of molecular experiments and formulation work, including RNA synthesis, modification, and purification, as well as the preparation and optimisation of lipid nanoparticles (LNPs) and other delivery formulations. You will also conduct in vitro assays encompassing cell culture, molecular analysis, and characterisation, alongside in vivo validation work.

Beyond experimental responsibilities, you will maintain accurate laboratory records and ensure proper documentation throughout. You will support general lab operations — including reagent preparation, equipment maintenance, and purchasing — while working collaboratively as part of a multidisciplinary team.

Jobrequirements:

• Bachelor’s degree in chemistry/ Materials Science, Molecular Biology, Biomedical Science, or related fields
• At least 2 years’ experience either in RNA therapeutics/ RNA synthesis/ RNA biology, or in Chemical synthesis/ LNP delivery
• Strong hands-on laboratory skills and experimental troubleshooting ability
• Good communication and organisational skills
• Documented proof of:

(i)Measles (or MMR - Mumps, Measles and Rubella) vaccination or serological evidence of measles immunity; and

(ii)Tdap (Tetanus, Diphtheria and Pertussis) vaccination received within the last 10 years, as required for all healthcare workers under the Healthcare Services Act. Applicants without these vaccinations may apply if they commit to completing the required vaccination(s) before work commencement, upon successful job offer.