Research Officer, RNA Encapsulation Processing (BTI)

Agency for Science, Technology and Research (A*STAR); Singapore; On-site; USD 40,000 - 80,000; Full time

Job summary

An established industry player is looking for a motivated individual to join their innovative research team focused on mRNA and lipid nanoparticles. This role involves preparing and optimizing processes for gene delivery systems, evaluating their effectiveness in cell lines, and conducting stability studies under various conditions. The successful candidate will contribute to vital in vivo studies and ensure the smooth operation of laboratory equipment. If you are passionate about advancing scientific research in a collaborative environment, this is an exciting opportunity to make a significant impact.

Qualifications

• Degree in biological science, chemistry, or related field required.
• Strong motivation and independence in work are essential.

Responsibilities

• Prepare mRNA/siRNA/ASO-loaded lipid nanoparticles for research.
• Evaluate gene transfection efficiency and study stability of nanoparticles.

Skills

Gene Transfection

Process Optimization

Interpersonal Skills

Communication Skills

Education

Bachelor in Biological Science

Bachelor in Chemistry

Bachelor in Pharmaceutical Science

Job description

Job Description

• Preparation of mRNA/siRNA/ASO-loaded lipid nanoparticles;
• Process optimization and development for encapsulation of gene in large scale;
• Evaluation of in vitro gene transfection efficiency induced by the lipid nanoparticles in cell lines;
• Study of stability of gene-loaded lipid nanoparticles under various storage conditions;
• In vivo toxicity and biodistribution studies;
• Participate in maintenance of equipment and procurement of equipment and consumables used for this project;
• Participate in lab safety and general housekeeping of the lab

Requirements

• Bachelor in biological science, chemistry, biomaterials or pharmaceutical science;
• Highly motivated and able to work independently
• Team player with good interpersonal skills
• Good spoken and written communication skills