Research Fellow (RNA Biology and Epigenetics)

Nanyang Technological University; Singapore; On-site; SGD 50,000 - 90,000; Full time

Job summary

An established industry player in biological sciences is seeking a motivated Research Fellow to join an innovative project focusing on RNA biology and epigenetics. This role involves designing experiments to explore lncRNA interactions and their role in cancer progression, utilizing advanced techniques such as CRISPR and RNA-FISH. You will work collaboratively within a dynamic research team, mentor junior staff, and contribute to scientific publications. This is a unique opportunity to advance your career in a supportive environment committed to scientific excellence and diversity.

Qualifications

• PhD in relevant fields is required with proficiency in RNA biology and molecular techniques.
• Strong communication skills and publication record are essential.

Responsibilities

• Design and execute experiments on lncRNA-RBP interactions and their epigenetic functions.
• Mentor junior staff and prepare manuscripts for publication.

Skills

Mammalian cell culture

Lentivirus production

RNA biology

Tumor xenograft mouse models

Strong written and oral communication skills

Education

PhD in Biology

PhD in Molecular/Cell Biology

PhD in Biochemistry

Tools

RNA immunoprecipitation (RIP)

RNA pull-down assay

RNA-FISH

CRISPR-mediated gene editing

ChIP-seq

Job description

Join Our Team at the School of Biological Sciences, Nanyang Technological University, Singapore

The School of Biological Sciences (SBS), part of the College of Science, was established in 2002 with a mission to advance biological and biomedical sciences. At SBS, our research spans various areas, including infectious diseases, immunology, neurodegenerative diseases, telomere biology, and genome function. Over the years, SBS has attracted talented individuals from around the world and Singapore to join as scientific leaders and researchers.

For more details, please view https://www.ntu.edu.sg/sbs.

We are looking for an ambitious Research Fellow to contribute to an RNA biology and epigenetics project in the laboratory of Assistant Professor Li Yinghui at SBS. The role will focus on characterizing the interactions of long non-coding RNAs (lncRNAs) with RNA-binding proteins (RBPs) and the epigenetic functions of these ribonucleoprotein complexes using cancer cell lines and in vivo tumor models. The work will also include the development of RNA-based therapeutics and evaluation of their efficacy using preclinical mouse models.

Key Responsibilities:

• Designing and executing experiments and analyses independently to characterize lncRNA-RBP interactions and epigenetic functions linked to cancer progression. Key techniques include RNA immunoprecipitation (RIP), RNA pull-down assay, RNA-FISH, RACE, molecular cloning, site-directed mutagenesis, CRISPR-mediated gene editing, CLIP-seq and ChIP/ChIP-seq.

• Organizing and documenting experimental procedures, reagents and data in a laboratory logbook.

• Preparing manuscripts and assist in writing grant proposals.

• Present research at lab meetings and local/international conferences.

• Mentor and train junior staff and students (undergraduate interns and postgraduate students) contributing to the research progress and productivity of the lab.

• Collaborative teamwork is essential.

Job Requirements:

• PhD in Biology, Molecular/Cell Biology, Biochemistry, or related disciplines.

• Proficiency in the following areas: Mammalian cell culture, lentivirus production and transduction, standard molecular biology and biochemical techniques, RNA biology, tumor xenograft mouse models.

• Strong written and oral communication skills.

• Strong publication record, especially at least a first author paper in the relevant areas.

• Entry level candidates with relevant experience are welcome to apply.

The College of Science seeks a diverse and inclusive workforce and is committed to equality of opportunity. We welcome applications from all and recruit on the basis of merit, regardless of age, race, gender, religion, marital status and family responsibilities, or disability.

We regret to inform that only shortlisted candidates will be notified.