Research Assistant (Dept of Pathology -RNA Bioanalysis)

National University of Singapore; Singapore; On-site; SGD 30,000 - 60,000; Full time

Job summary

Join a forward-thinking research team at an esteemed institution, focusing on the innovative field of RNA bioanalysis. As a Research Assistant, you will play a crucial role in developing and optimizing methods for RNA-based therapeutics, contributing to groundbreaking research that enhances the extraction and detection of small RNA therapeutics. This position offers the chance to work with advanced techniques and state-of-the-art laboratory facilities, collaborating with leading experts in the field. If you are passionate about molecular biology and eager to make a significant impact in RNA therapeutics, this opportunity is perfect for you.

Benefits

Access to state-of-the-art laboratory facilities

Collaboration with leading experts

Competitive salary

Dynamic research environment

Qualifications

• Bachelor's or Master’s in biological sciences or related field required.
• Hands-on experience with RNA extraction and PCR is essential.

Responsibilities

• Conduct small RNA extraction and optimize detection techniques.
• Analyze RNA integrity and collaborate with team members.

Skills

RNA extraction

PCR techniques

analytical skills

team collaboration

Education

Bachelor's degree in biological sciences

Master’s degree in biochemistry

Tools

mass spectrometry (LC-MS)

Job description

Job Description

We are seeking a highly motivated Research Assistant to join our team at National University of Singapore (NUS) for a project focused on developing and optimizing RNA bioanalysis methods for RNA-based therapeutics. This research aims to enhance the extraction and detection of small RNA therapeutics (siRNAs, gapmers, SSOs) from biological matrices (mouse plasma, liver, CSF, lung, kidney, muscle) using advanced techniques, including biotin-based probe hybridization capture and Stem-loop RT-PCR (SL-RT-PCR). The optimized protocols will contribute to the study of RNA drugs and RNA modification, facilitating the clinical translation of RNA-based therapeutics.

Key Responsibilities:

• Conduct small RNA extraction using various methods (e.g., hybridization capture).
• Optimize and validate detection techniques (e.g., SL-RT-PCR).
• Analyze RNA integrity, purity, and quantification in biological matrices.
• Assist in pharmacokinetic and pharmacodynamic studies.
• Maintain detailed records and collaborate with team members.

Qualifications

• Bachelor's or Master’s degree in biological sciences, biochemistry, molecular biology, or a related field.
• Hands-on experience with RNA extraction, PCR, and molecular biology techniques.
• Knowledge of mass spectrometry (LC-MS) -based RNA detection is a plus.
• Strong analytical skills and ability to work in a team-oriented environment.

More Information

What We Offer:

• Opportunity to contribute to cutting-edge RNA bioanalysis research.
• Access to state-of-the-art laboratory facilities at NUS.
• Collaboration with leading experts in RNA therapeutics.
• Competitive salary and a dynamic research environment.

Interested candidates, please send your CV and a short cover letter