Postdoctoral Researcher

Duke-NUS Medical School; Singapore; On-site; SGD 70,000 - 100,000; Full time

Job summary

The De Paola Lab at Duke-NUS Medical School is seeking a Research Fellow or Senior Research Fellow with in vivo expertise. This role involves independent research on human cortical circuit dysfunction, leading experiments, and contributing to grant applications. Candidates should have a PhD or MD with a strong publication record and expertise in neuroscience research.

Benefits

Access to state-of-the-art core facilities

Competitive salary

Career development support

Qualifications

• Strong first-author publications required.
• Experience with human stem cell neurobiology is an advantage.
• Proven ability to work independently and as part of a team.

Responsibilities

• Design and execute research projects independently.
• Lead or supervise junior researchers and students.
• Perform in vivo experiments including imaging and drug delivery.

Skills

In vivo calcium imaging

Stereotactic surgery

Gene expression analysis

Antisense oligonucleotides (ASO)

Strong analytical skills

Writing skills

Presentation skills

Education

PhD or MD

Job description

Research Fellow / Senior Research Fellow – In Vivo Neuroscience

Job Description

The De Paola Lab at Duke-NUS Medical School is seeking a highly motivated Research Fellow or Senior Research Fellow with strong in vivo expertise to join our team studying mechanisms and repair of human cortical circuit dysfunction in neurodevelopmental and neurodegenerative conditions such as Down syndrome (Lattke et al. Nature, under revision, Bass et al, iScience, under revision https://www.biorxiv.org/content/10.1101/2024.12.27.630526v2; Peter, Real et al, Reviews common under revision https://www.biorxiv.org/content/10.1101/2024.12.27.630530v2.full; Real et al Science 2018).

Our research combines in vivo and in vitro experimental platforms to explore mechanisms of synaptic and neural network activity dysfunction in the human neocortex. Using human iPSC-derived cortical neurons, functional loss-of-function approaches, single-nucleus RNA sequencing (snRNA-seq), xenotransplantation, and advanced in vivo imaging (e.g., 2-photon calcium imaging), we aim to uncover key pathways driving circuit pathology and identify targets for therapeutic intervention in neurodevelopmental and neurodegenerative brain conditions.

Key Responsibilities

• Design and execute research projects independently

• Lead or supervise junior researchers and students

• Perform in vivo experiments including imaging and viral/drug/ASO delivery

• Analyze data and maintain accurate records

• To ensure the validity and reliability of data at all times

• Write and present scientific findings

• Contribute to grant applications and research strategy

• Foster collaborations within and beyond Duke-NUS

Required Qualifications

• PhD or MD with strong first-author publications

• Desired Expertise in:

• In vivo calcium imaging (preferably 2-photon)

• Stereotactic surgery and drug delivery

• Gene expression analysis (e.g. snRNAseq)

• Antisense oligonucleotides (ASO)

• Experience with human stem cell neurobiology and mouse models is an advantage

• Strong analytical, writing, and presentation skills

• Proven ability to work independently and as part of a team

Why Join Us

• Work at the forefront of human circuit neuroscience and regenerative research

• Collaborate across basic, translational, and clinical institutions in Singapore

• Access state-of-the-art core facilities adjacent to Singapore General Hospital

• Benefit from a competitive salary and career development support in one of the world’s most livable cities

How to Apply

• Send a single PDF including:

• CV

List of publications

Statement of research interests (linking your experience to our lab's focus)

Please also arrange for two confidential reference letters to be sent directly to:

Applications will be reviewed on a rolling basis until the position is filled.

We regret that only shortlisted candidates will be notified.